Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcγRIIA and FcαRI면역 조절 : 면역 글로불린 제제는 FcγRIIA 및 FCαRI를 통해 COVID-19 모델에서 과인 염증을 억제합니다.Immunology Published on 2021-06-102022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] “cytokine storm” Activation addition Anti-inflammatory antibody cells characterized Clinical outcome coated with convalescent plasma COVID-19 COVID-19 disease COVID-19 pathology cytokine cytokine release Cytokine storm dissect drug dysregulated immune response elicit Fc-receptors FcγR followed by form functional global pandemic highlighting HL60 human immunoglobulin IgA IgG IgG and IgM IgM antibodies immune complex immune modulation immune modulatory drug immune modulatory drugs immune response Immunoglobulin immunoglobulins IMPROVE in vitro model include Inflammation Inflammatory Intravenous immunoglobulin ITAMi IVIG Model neutrophil Neutrophils pathology patients phagocytosis preparation reduced SARS-CoV-2 severe COVID-19 patients severe forms of COVID-19 Signaling Spike protein Spread tested therapeutic trimodulin [DOI] 10.3389/fimmu.2021.700429 PMC 바로가기 [Article Type] Immunology
Atomic force microscopy analysis of native infectious and inactivated SARS-CoV-2 virions원자력 현미경의 원자력 및 불 활성화 된 SARS-COV-2 비리 온의 원자력 현미경 분석Article Published on 2021-06-042022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] accelerate AFM Analysis analyzed atomic Atomic force microscopy biosafety BSL3 Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic enveloped virus formaldehyde inactivated inactivation Infectious virus Laboratory level 3 Microscopy morphology pandemic Plaque assay plaque assays preparation protocol responsible reveal Safe SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 virion the preparation Treatment virus viruses [DOI] 10.1038/s41598-021-91371-4 PMC 바로가기 [Article Type] Article
Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates2개의 새로운 아데노바이러스 매개된 COVID-19 백신 후보로 생쥐와 붉은털 원숭이의 프라임 부스트 백신 접종Research Article Published on 2021-06-012022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, [키워드] Adenovirus animals anti-RBD anti-S binding antibody candidate CD4 cells changes COVID-19 vaccine COVID-19 vaccines detectable dose-dependent manner elicit evaluated FIVE followed by full-length human adenovirus 49 vector IFN-γ IL-2 immune response immune responses Immunity immunization immunogenicity macaque macaques mice mice and non-human primates nCoV pathologic peptide peptides preparation prime-boost regimen prime-boost vaccination priming pseudovirus neutralizing antibody response rhesus macaque rhesus macaques SARS-CoV-2 spike protein simian adenovirus 23 vector Specific Spike protein T cell T-cell Response the vaccine trials vaccination Vaccine [DOI] 10.1080/22221751.2021.1931466 PMC 바로가기 [Article Type] Research Article
Animal models for SARS-Cov2/Covid19 research-A commentarySARS-Cov2/Covid19 연구용 동물 모델-A 논평Review Published on 2021-06-012022-09-11 Journal: Biochemical pharmacology [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 addition animal animal model BALB/c cellular receptor clearance clinical feature Clinical features Co-infection Combination COVID 19 COVID-19 COVID-19 disease COVID-19 pathogenesis Critical disease drugs Effect FCgRT Gene Expression hematologic homolog humanized Immunity IMPROVE Infection Initiation codon knock-out Lung pathology mechanism modeling mouse model Multigene humanized mouse models offer pathology platform Precision preparation primary antibody protease random receptor receptors Research researcher Responder responders resulting SAR-CoV-2 SARS CoV SARS CoV-2 SARS CoV-2 infection selected strain suggested targets Th1 Th2 therapeutic efficacy TMPRSS2 TMRPSS2 transgene transgenic model unnatural Vaccine Variability [DOI] 10.1016/j.bcp.2021.114543 PMC 바로가기 [Article Type] Review
Integrated knowledge translation to advance noncommunicable disease policy and practice in South Africa: application of the Exploration, Preparation, Implementation, and Sustainment (EPIS) frameworkResearch Published on 2021-05-172022-10-31 Journal: Health Research Policy and Systems [Category] Coronavirus, SARS, [키워드] analysed Analysis approach Bridging changes collaboration competent Consensus coronavirus disease COVID-19 Critical Culture disease Embedded research ENhance Evidence-informed decision-making Evolution exploration Exploration, preparation, implementation, and sustainment framework help implementation implementation research include Integrated knowledge translation Intervention iteration iterative knowledge Local Low- and middle-income countries management mapped Noncommunicable Diseases pandemic preparation Public reached remained Research uptake Resilience Result South South Africa stakeholder engagement thought translation [DOI] 10.1186/s12961-021-00733-x PMC 바로가기 [Article Type] Research
Differences in Adolescents’ Food Habits Checklist (AFHC) Scores before and during Pandemic in a Population-Based Sample: Polish Adolescents’ COVID-19 Experience (PLACE-19) Study인구 기반 표본에서 팬데믹 이전과 동안 청소년의 식품 습관 체크리스트(AFHC) 점수 차이: 폴란드 청소년의 COVID-19 경험(PLACE-19) 연구Clinical Trial Published on 2021-05-142022-08-13 Journal: Nutrients [Category] SARS, 임상, [키워드] adolescents Adolescents’ Food Habits Checklist (AFHC) Adults change changed checklist Complete conducted Coronavirus-19 COVID-19 COVID-19 pandemic current dessert dietary habit dietary habits difference experience food Food Habits fruit greater habit healthy increase in indicated lockdown lockdowns majority national study pandemic participant PLACE-19 Study Poland population-based study preparation pudding question random recruited Region reported required restaurant SARS-CoV-2 School score scored secondary schools study population sugar were assessed worsened [DOI] 10.3390/nu13051663 PMC 바로가기 [Article Type] Clinical Trial
Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina?중증급성호흡기증후군-코로나바이러스-2: 망막에서도 검출 가능한가요?Research Article Published on 2021-05-132022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] Analysis Can carried COVID-19 COVID-19 patients damage Deceased diagnosis of SARS-CoV-2 donors Effect eosin eye fluids hematoxylin Hematoxylin and eosin highest histopathological histopathological examination Histopathological examinations Histopathology humans Infection Inflammation investigated measure Morphological morphologically ocular organ performed Personal protective equipment Pharyngeal swab PPE preparation qRT-PCR Quantitative Result Retina SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA significant level tissue tissues vasculature vessel Viral Viral RNA vitreous vitreous fluid [DOI] 10.1371/journal.pone.0251682 PMC 바로가기 [Article Type] Research Article
A preparedness model for the provision of oral health care during unfolding threats: the case of the covid-19 pandemicResearch Published on 2021-05-122022-10-28 Journal: BMC Oral Health [Category] COVID-19, Fulltext, SARS, [키워드] asked average Canada Care categories category Characteristics coding COVID-19 COVID-19 pandemic Critical Dental model disease evaluate exploratory Future group group discussion Health Health care worker health care workers identify individual information inquiry interview Modification occurred oral health outbreak pandemic participant Participants Patient patients Perspective preparation qualitative research question recorded Result risk selected suggested thematic analysis transcribed transcripts was used [DOI] 10.1186/s12903-021-01627-8 PMC 바로가기 [Article Type] Research
Preparation for airway management in Australia and New Zealand ICUs during the COVID -19 pandemicResearch Article Published on 2021-05-072022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] airway airway management airway management practices analysed approach basic Clinical practice cognitive college COVID COVID-19 pandemic COVID-19 patient demographics high uptake ICU ICUs intensive care unit intubation management Medicine national guidelines New outcome measures pandemic Patient patients with COVID-19 performed PPE preparation presenting Prospective questionnaire reported Society specialist Specific tracheal intubation with COVID-19 [DOI] 10.1371/journal.pone.0251523 PMC 바로가기 [Article Type] Research Article
A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trialSARS-CoV-2 유발 급성 호흡곤란 증후군에 대한 정맥내 혈장 정제 알파-1 항트립신의 무작위 이중 맹검 위약 대조 파일럿 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-192022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hours active malignancy acute kidney Acute kidney injury acute respiratory distress syndrome addition Administered administration adverse event adverse events AEs age Alpha alpha-1 antitrypsin Amendment Anti-viral Antibiotics anticipated antitrypsin antivirals approval approved ARDS ARMS authority bacterial pneumonia baseline Berlin criteria blinded to treatment Blinding BMI body weight Cancer changes in Child-Pugh score chloride Chronic kidney disease chronic liver disease circulating class clinical Clinical outcome clinical trial Combination commenced Committee comparator Complete conducted Consent Controlled trial correction COVID-19 Culture cytokine level cytokine levels Data collection defined determine Diagnosis diagnosis of ARDS dialysis dissemination DNAR double-blind Echocardiogram Effect Effectiveness elapsed element ELISA enrolled EudraCT excluded exclusion exclusion criteria facilitate Follow-up followed by for inclusion group Health Products regulatory Authority hospital Hospital admission hypertension ICU IgA deficiency IL-10 IL-1β IL-6 IL-8 incidence inclusion criteria individual information intensive care unit intensive care units interim analysis interleukin interleukin-10 interleukin-1β interleukin-6 interleukin-8 interpreter Intervention intravenous intravenous infusion intravenously invasive investigational medicinal product investigator Ireland Kidney disease Laboratory laboratory-confirmed life Local maintain major trauma malignancy mandatory marker mechanical ventilation Microscopy moderate moderate to severe Mortality Non-invasive non-invasive mechanical ventilation non-invasive ventilation number objective occur Organ failure outcome outcome measure PaO participant Patient patient recruitment patients with moderate PCR-confirmed Phase 2 physician Placebo placebo-controlled plasma plasma analysis plasma concentration plasma concentrations pregnant preparation product protocol provided Pulmonary embolism pulmonary hypertension purified Radiographic randomisation randomisation list randomised randomised controlled trial rationale readmission REC receiving receptor recruited recruitment reduce Regulatory removal renal renal replacement therapy replacement therapy reported required Research Research Ethics Research Ethics Committee research nurse research nurses respiratory respiratory distress Respiratory distress syndrome resulting Resuscitation SAE SAEs Sample size SARS-CoV-2 secondary secondary bacterial pneumonia Secondary objective Secondary objectives Secondary outcomes secretion Sequential Organ Failure Assessment Serious Adverse Event Serious Adverse Events severe ARDS Shock single dose skin cancer Sodium chloride SOFA Standard statistician stratified study participation Study protocol subject submitted supplementary material Support sustained TNF TNF-α Tolerability trauma Treatment treatment allocation Trial trial protocol Trial registration vasopressors ventilator verbal Version Volume website WHO Withdrawal writing [DOI] 10.1186/s13063-021-05254-0 PMC 바로가기 [Article Type] Letter