Development of Improved High-Performance Liquid Chromatography Method for the Determination of Residual Caprylic Acid in Formulations of Human ImmunoglobulinsArticle Published on 2022-03-032022-10-30 Journal: Molecules [Category] Coronavirus, MERS, SARS, [키워드] 1:1 acid Analysis anti-SARS-CoV-2 applied caprylic acid Chromatography component convalescent convalescent anti-SARS-CoV-2 human plasma demonstrated Determination development factorial design Formulation fraction high-performance liquid chromatography method Human human immunoglobulin human immunoglobulins Human plasma ICH immunoglobulins Improved Laboratory linear liquid parameter preserved produced Quality Quality control quantification residual stationary supernatant therapeutic use validation was performed [DOI] 10.3390/molecules27051665 PMC 바로가기 [Article Type] Article
Cellular and humoral responses to SARS-CoV-2 vaccination in immunosuppressed patients면역 억제 환자에서 SARS-CoV-2 백신 접종에 대한 세포 및 체액 반응Article Published on 2022-03-012022-09-11 Journal: Cellular immunology [Category] SARS, 치료기술, [키워드] Activation anti-spike antibodies B-cell BNT162b2 BNT162b2 mRNA CD8 ChAdOx1 ChAdOx1 nCoV-19 cohorts comparable COVID-19 cytokine Cytokines demonstrated depleting detectable difference Efficacy elicited haematological malignancies haematological malignancy healthy healthy volunteers highest Humoral response humoral responses immunodominance immunogenic immunological responses Immunophenotyping Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression immunosuppressive immunosuppressive therapy less Longevity Lower memory naïve no significant differences non-responder participant Participants Patient patients treated phenotype preserved protective immunity receiving renal responders response SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines seroconvert serological seropositive Seropositivity significant difference T-cell T-cell ELISpot T-cell Response T-cell responses Th1 cytokine therapy Transplant Vaccinations vaccine immunogenicity vaccine response vaccine responses were used [DOI] 10.1016/j.cellimm.2022.104501 PMC 바로가기 [Article Type] Article
A tabulated summary of the evidence on humoral and cellular responses to the SARS-CoV-2 Omicron VOC, as well as vaccine efficacy against this variantSARS-CoV-2 Omicron VOC에 대한 체액 및 세포 반응에 대한 증거와 이 변이체에 대한 백신 효능에 대한 표 요약Review Published on 2022-03-012022-09-11 Journal: Immunology letters [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear appearance article B.1.1.529 bioRxiv Booster vaccine carried Cellular immune response cellular response coronavirus COVID-19 databases distribution dose Effectiveness Efficacy Evidence forms health authorities Health authority humoral humoral immune response Humoral response Immune escape immune system individual ineffectiveness infections medRxiv Mutation Neutralizing antibodies omicron preserved provided responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus solution South Africa SRAS-CoV-2 symptomatic the SARS-CoV-2 These data Transmission vaccination Vaccine Vaccine against COVID-19. variant variants virus VoC [DOI] 10.1016/j.imlet.2022.02.002 PMC 바로가기 [Article Type] Review
Impact of COVID-19 pandemic on STEMI undergoing primary PCI treatment in Beijing, ChinaResearch article Published on 2022-03-012022-10-05 Journal: The American journal of emergency medicine [Category] 치료법, [키워드] arrhythmia Beijing cardiac event China clinical cohort study Contact COVID COVID-19 COVID-19 infection COVID-19 outbreak COVID-19 pandemic death decrease defined diabetes disease Door-to-balloon enrolled Epidemic Frame heart failure Impact In-hospital investigated MACE measure multivariable analysis Myocardial infarction objective pandemic Patient patients predictor preserved Primary outcome Primary PCI Result selected significantly single center STEMI symptom onset Symptom-to-FMC Treatment Trial was used [DOI] 10.1016/j.ajem.2021.11.034 [Article Type] Research article
Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study항-CD20 약물에 대한 다발성 경화증 환자에서 COVID-19 항원에 대한 회상 반응이 보존됨 - 파일럿 연구Article Published on 2022-03-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] Coronavirus, MERS, SARS, 진단, [키워드] anti-CD20 anti-CD20 therapy antibody antibody levels antibody production Antibody Response Antibody titers Antigen B cell B cell depletion booster booster dose booster vaccination Booster vaccine both group Cell Cohort cohorts condition COVID-19 elicited enrolled evaluated humoral immunization implication individual management mean difference medication medications multiple sclerosis no correlation Patient peripheral circulation pilot study preserved proportion recall respond SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination significantly higher Therapies vaccination [DOI] 10.1016/j.msard.2022.103560 PMC 바로가기 [Article Type] Article
Titres and neutralising capacity of SARS-CoV-2-specific antibodies in human milk: a systematic review모유 내 SARS-CoV-2 특이 항체의 역가 및 중화 능력: 체계적인 검토Article Published on 2022-03-012022-09-12 Journal: Archives of disease in childhood. Fetal and neonat [Category] MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibody articles Asymptomatic asymptomatic infection CINAHL CNKI COVID-19 COVID-19 infection current database demonstrated disease Evidence Google Scholar Holder Human human milk IgA IgG IgM illness immunoglobulin A in vitro individual individuals with COVID-19 Infection lactating Mild milk neonatology neutralise neutralising Neutralising Antibodies neutralising antibody outcome performed Presence preserved provided SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 virus SARS-CoV-2-specific antibody selected severe disease severity Study design systematic review tested Virology WHO with COVID-19 [DOI] 10.1136/archdischild-2021-322156 PMC 바로가기 [Article Type] Article
Humoral Immune Response to COVID-19 Vaccination in Hemodialysis Patients: A Retrospective, Observational Case-Control Pilot Study혈액 투석 환자의 COVID-19 예방 접종에 대한 체액 면역 반응: 후향적, 관찰 사례-대조군 파일럿 연구Observational Study Published on 2022-03-012022-09-12 Journal: High blood pressure & cardiovascular prevention : [Category] MERS, SARS, 임상, 진단, [키워드] age Analysis Antibody activity Antigen BNT162b2 mRNA vaccine Case-control chronic hemodialysis patient Chronic kidney disease conducted Control control group coronavirus 2 COVID-19 disease exclusion Hemodialysis hyporesponsiveness in both groups increased mortality individual morbidity mRNA vaccination mRNA vaccines Outpatient participant Patient patients pilot study preserved renal function required response retrospective SARS-CoV-2 vaccination second dose serum antibody Support the SARS-CoV-2 [DOI] 10.1007/s40292-021-00502-5 PMC 바로가기 [Article Type] Observational Study
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunitySARS-CoV-2 변이 스파이크 에피토프의 인식에서 벗어나 T 세포 면역의 전반적인 보존Article Published on 2022-02-092022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Ability to protect Affect African Beta Beta variant CD4 CD4 T cells CD8 CD8 T cell CD8 T cell responses COVID-19 patient detectable dominant Efficacy epitope Epitopes escape explain First wave first-wave immune evasion Immunity immunogenic mounted mutated neutralization neutralizing antibody observation Patient patients peptide peptides preserved proportion PROTECT Recognition recognize Region regions Reinfection residue response retained robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 severe disease South spike epitope spike epitopes spike mutation spike mutations T cell T cell response T cell responses T cells tested Vaccine vaccine efficacy variant wild-type Wuhan strain [DOI] 10.1126/scitranslmed.abj6824 PMC 바로가기 [Article Type] Article
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individualsNK 세포 빈도, 기능 및 BNT162b2 mRNA 항 SARS-CoV-2 예방 접종을 받은 건강하고 면역이 약한 개인에서 백신 결과와 상관 관계Research Article Published on 2022-02-082022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive immune responses anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 mRNA vaccine Cancer characterized clinical material clinical trial Course COVID-19 Day description Effect EudraCT frequencies Frequency healthy healthy individuals immune cells immune response immune responses Immunocompromised immunocompromised individual Immunocompromised patient Immunocompromised patients in healthy individual Innate immune cells Innate immunity mRNA mRNA vaccination mRNA vaccine mRNA-based NK cell NK cells NKG2C non-randomized Open-label outcome Peripheral blood Phenotypes positive correlation preserved Prospective clinical trial Registered Result SARS-CoV-2 supplementary material Trial registration vaccination Vaccine vaccine trial viral infections [DOI] 10.1186/s10020-022-00443-2 PMC 바로가기 [Article Type] Research Article
Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies혈액암 환자에서 mRNA-1273 SARS-CoV-2 백신의 세포 및 체액 면역원성Article Published on 2022-02-082022-09-12 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Active disease acute respiratory syndrome age anti-CD20 therapy Anti-SARS-CoV-2 S assays B-cell cellular cellular response coronavirus diagnosed disease Elecsy evaluate GVHD hematologic Hematologic malignancy humoral Humoral immunity humoral immunogenicity Humoral response immunoassay Immunosuppressive agents Immunosuppressive treatment implication interferon-γ LIAISON lymphopenia management Messenger RNA mRNA mRNA-1273 mRNA-1273 vaccine observation Patient patients patients treated preserved recent SARS-CoV-2 SARS-CoV-2 vaccine second dose shown T-cell T-cell Response the SARS-CoV-2 Treatment Vaccine were measured [DOI] 10.1182/bloodadvances.2021006101 PMC 바로가기 [Article Type] Article