Basic residues at the C-gate of DNA gyrase are involved in DNA supercoilingDNA 기어레이스의 C-게이트에 있는 기본 잔여물은 DNA 슈퍼코일링에 관여한다.Research Article Published on 2021-07-222024-07-30 Journal: Brain stimulation [Category] 폐렴구균 감염증, [키워드] BSA, bovine serum albumin DNA topoisomerases G-segment, gate segment Mutagenesis protein structure protein–DNA interactions structure–function T-segment, transport segment WHD, winged-helix domain [DOI] 10.1016/j.jbc.2021.101000 PMC 바로가기 [Article Type] Research Article
In-silico screening for identification of potential inhibitors against SARS-CoV-2 transmembrane serine protease 2 (TMPRSS2)SARS-CoV-2 막횡단 세린 프로테아제 2(TMPRSS2)에 대한 잠재적 억제제 식별을 위한 인실리코 스크리닝Article Published on 2021-07-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding energy binding free energy bridge calculated calculation China complex Compound condition coronavirus COVID COVID-19 docking downloaded drug drug repositioning eight Emergency form free energy highest homology human cell hydrogen Hydrogen bond hydrophobic hydrophobic interactions infected patients inhibitor Interaction Mechanics Medicine Medicines MM/PBSA molecular docking Molecular mechanics pandemic performed Physicochemical properties Protein protein structure protein-ligand reducing Research residues respiratory infection responsible salt Salt Bridge SARS-CoV-2 SARS-CoV-2 virus screened Serine serine protease Spread stability the SARS-CoV-2 virus TMPRSS2 TMPRSS2 protein transmembrane region transmembrane serine protease transmembrane serine protease 2 Transmissibility viral entry Virtual screening virus were used Wuhan Zinc ZINC database [DOI] 10.1016/j.ejps.2021.105820 PMC 바로가기 [Article Type] Article
Immunogenicity and structural efficacy of P41 of Plasmodium sp. as potential cross-species blood-stage malaria vaccineArticle Published on 2021-06-302024-09-10 Journal: Comput Biol Chem [Category] 말라리아, [키워드] 6-Cysteine immunogenicity malaria protein structure Vaccine PMC 바로가기
Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2SARS-CoV-2에 대한 내성을 부여하는 영장류 ACE2 변이체 식별Article Published on 2021-06-252022-09-25 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] ACE2 ACE2 gene sequence ACE2 residue ACE2 variant Analysis angiotensin angiotensin I apes binding binding affinity collected Complete complex COVID-19 enzyme evaluate the effect Human Human angiotensin I humans identifying increase infect New World New World monkey nine Old World monkey Philippine tarsier primate primates Protein protein structure reducing reduction in resistance resistant to SARS-CoV-2. S-protein SARS-CoV-2 SARS-COV-2 infection sequence Spike protein susceptibility susceptible the binding affinity variant variants [DOI] 10.1093/molbev/msab060 PMC 바로가기 [Article Type] Article
Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular FlexibilityReview Published on 2021-05-212022-10-28 Journal: Biology [Category] COVID-19, [키워드] binding C-terminal domain cause coronavirus disease coronavirus nucleocapsid protein coronavirus SARS-CoV-2 COVID-19 CTD described domains droplet droplets drug drug target flexibility fluctuation function high affinity in viral Infection information Interaction involved liquid-liquid phase separation molecular molecular flexibility molecular mechanism N-terminal domain neutron scattering NTD nucleocapsid protein pandemic physicochemical property Pneumonia Protein Protein dynamics protein structure Proteins recent Replication reported Research RNA RNA genome SARS-CoV-2 scattering shown simple Simulation study term the SARS-CoV-2 Viral protein viral replication [DOI] 10.3390/biology10060454 PMC 바로가기 [Article Type] Review
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection인간 ACE2 유전자의 고위험 미스센스 변이체 및 SARS-CoV-2 감염에 대한 감수성의 실리코 분석Research Article Published on 2021-04-092022-09-10 Journal: BioMed Research International [Category] 변종, [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed angiotensin Angiotensin II Angiotensin-converting enzyme bioinformatics ConSurf conversion coronavirus cumulative score Deleterious functional host cells Human human host cell human host cells in silico analysis information less missense variant Modification nucleotide pathogenic Protein protein structure proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability STRING susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article
Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactionsSARS-CoV-2 돌연변이가 단백질 구조 및 바이러스 내 단백질-단백질 상호작용에 미치는 영향Article Published on 2021-04-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect affected analyzed binding affinity caused changes in Characteristics complexes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis docking Effect Frame globe Impact in some incidence incidence rate incidence rates Interaction interface investigated involved mutant Mutation nonsynonymous mutation Novel coronavirus nucleocapsid occurred Occurrence ORF3a ORF8 pandemic physiological Protein protein interactions protein sequence protein structure protein-protein interaction Q57H RMSD SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 transmission severe acute respiratory syndrome Coronavirus Spread Structure structures the binding affinity the SARS-CoV-2 genome Treatment variance Viral protein virus genome [DOI] 10.1002/jmv.26597 PMC 바로가기 [Article Type] Article
Ligand-based approach for predicting drug targets and for virtual screening against COVID-19약물 표적 예측 및 COVID-19에 대한 가상 스크리닝을 위한 리간드 기반 접근 방식Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted applied approach Betacoronavirus binding pocket caused charge complementary Compound compounds conformation coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 D3Similarity database deficiency demonstrated docking drug Drug discovery drug target Efficiency False negative false negative results Feline infectious peritonitis free of charge HCoV HCoV-229E HCoV-EMC human betacoronavirus human CoV human CoV 229E information inherent lack mechanism MERS Middle East Middle East respiratory syndrome Coronavirus molecular performed platform Protein protein structure Proteins reliability reported respiratory syndrome coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus similarity structures submitted target target prediction target protein target proteins two-dimensional Virtual screening virus [DOI] 10.1093/bib/bbaa422 PMC 바로가기 [Article Type] Article
Applications of Protein Secondary Structure Algorithms in SARS-CoV-2 ResearchSARS-CoV-2 연구에서 단백질 2차 구조 알고리즘의 적용Review Published on 2021-03-052022-09-11 Journal: Journal of Proteome Research [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors Algorithm Algorithms Amino acid amino acid sequence Analysis application binding affinity can be used can not compare protein Complete computational tool computational tools Contact Course COVID-19 evaluate example experiments explained faster Genome global effort help highlight homology information nucleotide pandemic Pandemics Protein protein similarity protein structure question reflected required Research SARS-CoV-2 SARS-CoV-2 spike protein secondary secondary structure sequence sequence similarities similarity Spike protein Structure the binding affinity Vaccine design viruses while zoonotic origin zoonotic origins [DOI] 10.1021/acs.jproteome.0c00734 PMC 바로가기 [Article Type] Review
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity순환하는 SARS-CoV-2 스파이크 N439K 변이체는 항체 매개 면역을 피하면서 체력을 유지합니다Article Published on 2021-03-042022-09-11 Journal: Cell [Category] Fulltext, SARS, 변종, 진단, [키워드] antibody Antibody therapeutics binding affinity Clinical outcome consequence COVID-19 disease drug Efficacy Emergency use epidemiological evade FDA fitness food hACE2 hACE2 receptor highlighting Immunity immunodominant increase Infection Lineage mAb mAbs maintain molecular monoclonal antibody escape mutate Mutation N439K neutralizing monoclonal antibodies neutralizing monoclonal antibody polyclonal polyclonal antibody polyclonal sera prevalent protein structure RBM receptor binding motif receptor-binding motif reduce reducing Replication response responses S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike spike Surveillance the SARS-CoV-2 Therapeutics US Food and Drug Administration Usage Vaccine variable region variant Viral viral fitness virulence virus viruses wild type wild-type [DOI] 10.1016/j.cell.2021.01.037 PMC 바로가기 [Article Type] Article