Pulmonary edema – Page 5 – Communicable Diseases Research

Can GPR4 Be a Potential Therapeutic Target for COVID-19?

Medicine

Published on 2021-01-212022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

A Potential Role of the Renin-Angiotensin-System for Disturbances of Respiratory Chemosensitivity in Acute Respiratory Distress Syndrome and Severe Acute Respiratory Syndrome

Physiology

Published on 2021-01-202022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

COVID-19—The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection

Review

Published on 2021-01-172022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] ACE2 expression acute lung injury acute respiratory distress Acute respiratory infection androgen receptor antagonist animal models ARDS ARDS (Acute Respiratory Distress Syndrome) benefit caused Clinical course complications of COVID-19 concerning coronavirus coronavirus disease COVID-19 COVID-19 infection Effect evaluate Future global pandemic highest inhibitor medication MRS pandemic Patient patients with COVID-19 pleiotropic pleiotropic effect Pneumonia potassium canrenoate Potential Prevent Prospective clinical trial Pulmonary edema pulmonary fibrosis RAAS receptor reducing reduction in risk Safe SARS-CoV-2 severe pneumonia shown spironolactone syndrome the disease Therapeutic benefit therapeutic potential TMPRSS2 transmembrane serine protease WHO World Health Organization
[DOI] 10.3390/ph14010071 PMC 바로가기 [Article Type] Review

Characterization of pulmonary impairment associated with COVID-19 in patients requiring mechanical ventilation

Original Article

Published on 2021-01-012022-10-29
Journal: Revista Brasileira de Terapia Intensiva [Category] COVID-19,

Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology?

Review Article

Published on 2020-12-252022-10-28
Journal: Physiological Reports [Category] COVID-19,

[키워드] administration animal model approach benefit biogenesis bronchitis candidate cathepsin Cell cell entry cleavage complex compounds contributed CoV COVID‐19 COVID‐19 Cytokine release syndrome disease pathogenesis Disease progression disrupt disrupting drug Efficacy endocytic endosomal complexes required for transport endosomal pH entry pathway envelope exacerbate Exosome Exosomes extracellular vesicle Extracellular vesicles glycosylation Golgi Infection inhibit inhibiting inhibitor involved mechanism membrane mice Microvesicles multivesicular body occur Pathogenesis plasma membrane PPI promote Pulmonary edema pulmonary epithelial cell reported serine protease TMPRSS2 Spike protein suggested therapeutic Transport Vesicle viral endocytosis viroporin viruses
[DOI] 10.14814/phy2.14649 PMC 바로가기 [Article Type] Review Article

Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

Observation

Published on 2020-12-112022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 expression ACE2 receptor activate activating acute respiratory distress Affect alveolar angiotensin-converting enzyme 2 ARDS Brain cause characterized ciliated epithelial cell Coagulation Coagulopathy COVID-19 COVID-19 patient COVID-19 patients Critical Diffuse alveolar damage dysfunction dysregulated edema elicit Endothelial cell endothelial cells Endotheliitis Endothelium epithelial explain function Gas exchange hemorrhage Human indicate infect infecting Infection Inflammation Inflammatory response kidney tissues lack Multiorgan dysfunction occur progressive respiratory failure Protein pulmonary Pulmonary edema pulmonary epithelial cell receptor recombinant recombinant ACE2 regulate Regulation resolved response responses resulting RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Syncytia syndrome therapeutic targets thrombosis transduced umbilical upper respiratory tract Vascular Vascular function Viral pneumonia viral titer
[DOI] 10.1128/mBio.03185-20 PMC 바로가기 [Article Type] Observation

COVID-19 pneumonia: the great radiological mimicker

Educational Review

Published on 2020-11-232022-10-29
Journal: Insights into Imaging [Category] COVID-19,

[키워드] acute respiratory syndrome aspiration pneumonia caused change Chest CT Combination consolidations coronavirus Coronavirus disease 2019 COVID-19 creating CT finding described Diagnosis diagnostic differential diagnose differential diagnoses differential diagnosis disease feature GGO GGOs ground-glass opacity hemorrhage include Infarction interfere Interstitial lung diseases less longitudinal lung abnormality Lung pathology Mimicker Neoplasms non-infectious disease Organizing pneumonia Pneumonia Pulmonary alveolar proteinosis Pulmonary edema radiological reported RT-PCR sarcoidosis SARS-CoV-2 sensitivity septal thickening Spread the disease tomography
[DOI] 10.1186/s13244-020-00933-z PMC 바로가기 [Article Type] Educational Review

Mesenchymal Stem Cells (MSCs) as a Potential Therapeutic Strategy in COVID-19 Patients: Literature Research

Cell and Developmental Biology

Published on 2020-11-192022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] anti-inflammatory activity ARDS Biology cell-based therapies Cell-based therapy Characteristics China coronavirus COVID-19 COVID-19 disease COVID-19 patients Critical Critical case Cytokine storm dimension effective therapy Engineering Health literature lung Medicine mesenchymal stem cell Mesenchymal stem cells MSC MSCs outbreak outcome pandemic Pathologies Pneumonia positive Potential Pulmonary edema pulmonary inflammation raised reported representing respiratory responsible SARS-CoV-2 Secretome shown specific treatment STEM Strategy Symptoms symptoms of COVID-19 therapeutic potential therapeutic strategy these cell Treatment Vaccine were used
[DOI] 10.3389/fcell.2020.602647 PMC 바로가기 [Article Type] Cell and Developmental Biology

Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ Failure

Pharmacology

Published on 2020-11-102022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] activity acute lung injury acute respiratory distress adverse event AEs Affect Alpha Anti-inflammatory anti-inflammatory agents ARDS Cancer clinical Clinical course Clinical practice clinical study Compliance complications coronavirus disease COVID-19 COVID-19 patient Cytokine release syndrome dose-dependent dose-escalation double-blind evaluate examined exhibited failure GRADE growth factor healthy histopathological examination Human ICH include Inflammatory cytokine ingredient interleukin-6 intravenous Liver damage Model mortality rate mouse multi-organ dysfunction multi-organ failure Necrosis New niacinamide Patient patients phosphate placebo-controlled platform Pneumonia potent Preclinical Prevent profile Protective Pulmonary edema Randomized reduce respiratory response Riboflavin SAEs Safety safety profile Sepsis Serious Adverse Event Shock show Standard statistical analysis subject subjects survival syndrome Tolerability Treatment was performed
[DOI] 10.3389/fphar.2020.594321 PMC 바로가기 [Article Type] Pharmacology

Phosphatidylglycerol and surfactant: A potential treatment for COVID-19?

Research article

Published on 2020-11-012022-10-05
Journal: Medical Hypotheses [Category] 치료법,

[키워드] Activation acute respiratory distress syndrome addition administration approved ARDSacute respiratory distress syndrome benefit cellular component concerning Critically ill patient damaged damaged cells DAMPdanger- or damage-associated molecular pattern danger- or damage-associated molecular pattern death decrease distress drug food Hypothesis ILInterleukin IMPROVE individual Infants Inflammation innate immune system interleukin limit lung Lung function Lung infection Lung pathology microbial mitigate Neonatal NFκBnuclear factor kappa-light-chain-enhancer of activated B cells non-infected cell nuclear factor kappa-light-chain-enhancer of activated B cells PAMPpathogen-associated molecular pattern pathogen-associated molecular pattern PGphosphatidylglycerol phosphatidylglycerol Potential treatment Protein Pulmonary edema reducing released secretory phospholipase A2 sPLA2secretory phospholipase A2 Spread suggested syndrome tension tested thought TLRToll-like receptor TNFαtumor necrosis factor-alpha Toll-like receptor treat Treatment tumor necrosis factor-alpha Type II pneumocyte utility viral infection with COVID-19 Work of breathing
[DOI] 10.1016/j.mehy.2020.110277 [Article Type] Research article