Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus유행성, 전염병, 풍토병: B 세포 레퍼토리 분석을 통해 SARS-CoV-2, 에볼라 및 호흡기 세포융합 바이러스에 대한 독특한 항바이러스 반응이 밝혀졌습니다Article Published on 2022-05-032022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Analysis B cell Characteristics class-switch recombination (CSR) cohorts COVID-19 COVID-19 patient disease Ebola Ebolavirus Effects Endemic Epidemic event Evidence example Fever germinal centre heterogeneity humoral humoral immune response Hypothesis IgG1 IGH IGHV4-39 immature Immunity infections lack Lineage morbidity and mortality Mutation pandemic patients Recombination reflect repertoire respiratory response risk RSV RSV (respiratory syncytial virus) SARS-CoV-2 Sequencing significant difference Support survivor switching unique vaccination Vaccine viral challenge viral infection Zaire [DOI] 10.3389/fimmu.2022.807104 PMC 바로가기 [Article Type] Article
Functional reconstitution of the MERS CoV receptor binding motifMERS CoV 수용체 결합 모티프의 기능적 재구성Article Published on 2022-05-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E beta-coronaviruses catastrophic caused Co-infection Combinatorial phage display common cold coronavirus Coronaviruses CoV COVID-19 develop disease Diseases epitope Epitope reconstitution Epitope-based vaccine etiologic agent event Evolution Fatality rate followed by Human human coronavirus human-to-human transmission Implementing incidence independent Isolation less life-threatening MERS MERS CoV. Middle East neutralizing monoclonal antibodies OC43 omicron Omicron variants pandemic Population Prevalence Protein RBM receptor binding motif Recombination reported Respiratory disease respiratory diseases SARS CoV Saudi Arabia Seven shown spike Spike protein subsequent summer variants of concern viruses [DOI] 10.1016/j.molimm.2022.03.006 PMC 바로가기 [Article Type] Article
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination eventsSARS-CoV-2 Omicron의 다양한 스파이크 유전자 돌연변이를 추적하여 여러 변이체 간 재조합 이벤트를 식별합니다.Article Published on 2022-04-262022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Alpha Amino acid attribute change characteristic Co-infection Delta dominant epitope Epitopes Evolution of SARS-CoV-2 Frequency Genome identify in some include mechanism modifications monitoring MOST Mutation nine omicron other variant other variants pandemic of COVID-19 Pathogens phylogenetically Recognition recombinants Recombination recombination event Revertant SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes scanning South Africa spike gene Spike protein subsequent the spike protein Vaccine variant variants variants of interest viral pathogens VOCs VOIs [DOI] 10.1038/s41392-022-00992-2 PMC 바로가기 [Article Type] Article
Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment Research Published on 2022-04-252022-10-05 Journal: Nature Microbiology [Category] 변종, 유전자 메커니즘, [키워드] A. fumigatus acquisition Analysis Aspergillus fumigatus biosynthetic canonical caused clade defined driver drug resistance drug-resistant drugs fungal genes encoding Genetic Genomic analysis Genotype Human increasingly Infection Ireland isolate isolates loci majority numbers of patient Occurrence pathogen pathway Patient population genomics Positive selection Recombination Region resistance mechanisms second selective sweep susceptible susceptible patient transmitted understanding viral respiratory [DOI] 10.1038/s41564-022-01091-2 [Article Type] Research
Ubiquitous Micro-Modular Homologies among Genomes from Viruses to Bacteria to Human Mitochondrial DNA: Platforms for Recombination during Evolution?바이러스에서 박테리아, 인간 미토콘드리아 DNA에 이르기까지 게놈 간의 유비쿼터스 마이크로 모듈식 상동성: 진화 중 재조합을 위한 플랫폼?Article Published on 2022-04-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome annealing appear Bacterial Biology Cluster coding comparison computer Control DNA DNA sequence domain Escherichia Escherichia coli Evolution four letter genetic encoding system Genetic Genome genome segment genomes Human identity investigated mechanism micro-modular identities in 1000 randomized SARS-CoV-2 genomes micro-modular sequence identities mitochondrial mitochondrial DNA nucleotide nucleotide sequence nucleotides Numerous patch type sequence similarities platform question raised Randomized Randomly Recombination respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA SARS-CoV-2 RNA compared to genomes of many viruses, protobacteria, Escherichia coli SARS-CoV-2 sequence sequence sequence identity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signals for evolution, annealing and integrative recombination the 4,641,652 nt DNA sequence of Escherichia coli K12. variant variants viruses Wuhan [DOI] 10.3390/v14050885 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Evolution: On the Sudden Appearance of the Omicron VariantSARS-CoV-2 진화: 오미크론 변종의 갑작스러운 출현Article Published on 2022-04-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appearance coronavirus Evolution Frame hypermutation mechanism Mutation omicron Omicron variant Recombination repeated SARS-CoV-2 severe acute respiratory syndrome Coronavirus spike mutations Spike protein Spread sudden the spike protein variant virus [DOI] 10.1128/jvi.00090-22 PMC 바로가기 [Article Type] Article
Genomic and epidemiological report of the recombinant XJ lineage SARS-CoV-2 variant, detected in northern Finland, January 20222022년 1월 핀란드 북부에서 검출된 재조합 XJ 계통 SARS-CoV-2 변이체의 게놈 및 역학 보고서Article Published on 2022-04-012022-09-11 Journal: Eurosurveillance [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] breakpoint circulating collected community transmission epidemiological epidemiological data Genome genomic Lineage nucleotide nucleotide position omicron ORF1 ORF1b recombinant Recombination S gene SARS-CoV-2 SARS-CoV-2 variant sequence Surveillance sustained the SARS-CoV-2 variant XJ-lineage [DOI] 10.2807/1560-7917.ES.2022.27.16.2200257 PMC 바로가기 [Article Type] Article
Molecular phylogeny of coronaviruses and host receptors among domestic and close-contact animals reveals subgenome-level conservation, crossover, and divergence국내 및 밀접 접촉 동물 사이의 코로나바이러스 및 숙주 수용체의 분자 계통 발생은 하위 게놈 수준의 보존, 교차 및 분기를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphacoronavirus alphacoronaviruses aminopeptidase N analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals APN binding cathepsin L cattle Comparative Comparative phylogeny Complete conservation conserved Consistency coronavirus Coronavirus-2 Coronaviruses Critical cross determine dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 enzyme Enzymes events explain Factor furin furin cleavage furin cleavage motif genome sequence Genome sequences Host host receptor Host receptors hosts identify infecting intermediate host Intersection membrane MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular N protein N proteins nucleocapsid offer other coronavirus other coronaviruses Phylogenetic tree phylogenies Phylogeny polybasic Protein Protein binding Proteins receptor receptors Recombination respiratory syndrome coronavirus retained reveal S proteins S, E, M, and N proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SAS segregation sequence Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sialic acid similarities similarity spike Spike protein Support the S protein theory TMPRSS2 transmembrane serine protease transmembrane serine protease 2 unique Viral protein Viral proteins virus white-tailed deer β-coronavirus [DOI] 10.1186/s12917-022-03217-4 PMC 바로가기 [Article Type] Article
Comparative Analysis of SARS-CoV-2 Variants of Concern, Including Omicron, Highlights Their Common and Distinctive Amino Acid Substitution Patterns, Especially at the Spike ORF오미크론을 포함한 우려되는 SARS-CoV-2 변이체의 비교 분석은 특히 스파이크 ORF에서 공통적이고 독특한 아미노산 치환 패턴을 강조합니다Comparative Study Published on 2022-03-292022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acid Alpha Amino acid amino acid substitution amino acid substitutions Analysis Beta common Comparative concern COVID-19 Delta dN/dS Evolution Gamma highest homologous hotspot human host Hypothesis Including introduced investigated Lambda Lineage lineages mutated mutations omicron ORF phylogenetic distribution Point mutation Positive selection RBD Receptor binding domain Recombination recurrent mutations residue Sarbecoviruses SARS-CoV-2 significantly higher spike Substitution the Spike vaccination variant variants variants of concern was performed [DOI] 10.3390/v14040707 PMC 바로가기 [Article Type] Comparative Study
Evidence for Recombination as an Evolutionary Mechanism in Coronaviruses: Is SARS-CoV-2 an Exception?Article Published on 2022-03-172023-06-16 Journal: Frontiers in Public Health [Category] MERS, SARS, [키워드] coronavirus COVID-19 Evolution Recombination SARS viral recombination [DOI] 10.3389/fpubh.2022.859900 PMC 바로가기