The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2
Genome Replication and Regulation of Viral Gene Expression
[키워드] activities
activity
acute respiratory syndrome
affecting
Alpha
Amino acid
antiviral drug
Betacoronavirus
betacoronaviruses
boost
can be used
complex
coronavirus
CoV
CoVs
Critical
decrease
displaying
domains
enzymatic activity
enzyme
evaluated
example
Exoribonuclease
Frequency
Genetic
genetics
genome replication
guanine-N7-methyltransferase
In vitro assay
MERS-CoV
MHV
Middle East
MONITOR
mouse hepatitis virus
mRNA
mutant
mutants
Mutation
nidovirus
nonstructural protein
nsp14
Nsps
observation
occurred
phenotype
Phenotypes
progeny
promote
Proofreading
purified
replicase
replicate
Replication
replication fidelity
replicative
reported
respiratory syndrome coronavirus
reverse genetics
RNA genome
RNA synthesis
SARS-CoV
SARS-CoV-2
sequence identity
single mutant
subunit
Support
thought
viral RNA synthesis
viruses
while
[DOI] 10.1128/JVI.01246-20 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression
[DOI] 10.1128/JVI.01246-20 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression