Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and OutcomeCOVID-19 사망률 환자의 상부 기도에서 증가된 Achromobacter xylosoxidans 및 Bacillus cereus는 질병 심각도 및 결과에서 공동 감염의 역할을 나타냅니다.Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] abundance Achromobacter Actinomyce Alter Analysis Antibiotic therapy approaches Bacillus cereus Bacterial bacterial species bacterial specy Care clinical manifestation Co-infection complementary complications of COVID-19 contribute COVID-19 COVID-19 patient current disease disease outcome disease pathology disease severity disease sub-phenotype Exacerbation Factor feature functional groups highlight Holo-Seq hospital host-pathogen interactions Increased Inflammatory response Inflammatory responses Integrative analysis investigated involved isolate isolates Leptotrichia mechanism Medical care metabolic pathways microbe microbial Mild mild COVID-19 patients moderate modulate modulating Mortality nasopharyngeal nasopharyngeal RNA outcome parameters pathogen pathogen genomics Patient patients phenotype Phenotypes Phylogenetic analysis progression provide question recovered patient recovered patients reported respiratory virus respiratory virus oligo panel (RVOP) role SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 pathogenesis Sequencing severe COVID-19 severe disease severity susceptibility Symptoms the disease the patient transcript transcriptionally transcriptionally active microbial isolates. Transmissibility upper vaccination variants variants of concern VoC window [DOI] 10.1128/spectrum.02311-21 PMC 바로가기 [Article Type] Article
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationZ-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할Review Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus Z-RNA ZBP1 zoonotic transmission [DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review
Role of the cGAS–STING pathway in systemic and organ-specific diseases Reviews Published on 2022-06-222022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, 치료제, [키워드] activate activated Antiviral Autoimmune bind Cancer conserved cytokine dinucleotide disease DNA Endoplasmic reticulum ENhance enzyme explain genomic high affinity Immune cell immune response implicated Inflammatory response inhibitor interferon Kidney injury Ligand metabolism mitochondrial neurodegenerative nucleic acids nucleotide organ-specific pathway pro-inflammatory promote Protein recognize role sequence specificity stimulate stimulated triggered type I interferon viral infections viruses [DOI] 10.1038/s41581-022-00589-6 [Article Type] Reviews
Exploring the Role of Low-Density Neutrophils During Mycobacterium tuberculosis Infection결핵균 감염 중 저밀도 호중구의 역할 탐색Review Published on 2022-06-212022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, 진단, [키워드] addition association caused centrifugation COVID-19 disease Disease progression disease severity driven by elicit expression Frequency highlight highlighting Host immune response increase in infect Infection infections Inflammation inflammatory host response low-density low-density neutrophil lung Lung inflammation marker MDSC (myeloid-derived suppressor cell) mounted Mycobacterium tuberculosis NDN neutrophil outcome outcomes pathology recent recent finding recruitment role separated severity subpopulation the disease tissue damage Tuberculosis [DOI] 10.3389/fcimb.2022.901590 PMC 바로가기 [Article Type] Review
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2SARS-CoV-2의 스파이크 단백질은 지질 대사를 손상시키고 지방독성에 대한 감수성을 증가시킵니다: Nrf2의 역할에 대한 의미Article Published on 2022-06-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations autophagic autophagic pathway autophagy Cell cell line cell membrane cell membranes control cell control cells controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose-dependent manner dysregulation exhibited expression expression profile Ferroptosis Gene Expression Gene expression profiles HEK293 host cells impair increase inhibitor investigated Lipid lipid metabolism lipotoxicity mechanism metabolism molecules multifunctional Necrosis Nrf2 nuclear palmitic acid pathway Patient Protein role SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant increase spike Spike protein suppressed susceptibility the Spike transcriptional trigonelline upregulation was used [DOI] 10.3390/cells11121916 PMC 바로가기 [Article Type] Article
Role of procalcitonin as a predictor of clinical outcomes in hospitalized patients with COVID-19Research article Published on 2022-06-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 바이오마커, [키워드] Admission analyzed C-reactive protein chronic clinical Clinical outcome clinical outcomes correlation COVID-19 demographic data demonstrated determine elevated Evidence group groups hospital hospitalized patient ICU in-hospital mortality inclusion criteria intensive care Kaplan-Meier analysis Laboratory logistic regression model Mortality multivariable objective Patient patients hospitalized PCT Physiology procalcitonin Prognosis Result role severity significantly statistical were used with COVID-19 [DOI] 10.1016/j.ijid.2022.03.044 [Article Type] Research article
Role of triggering receptor expressed on myeloid cells-1 (TREM-1) in COVID-19 and other viral pneumonias: a systematic review and meta-analysis of clinical studiesCOVID-19 및 기타 바이러스성 폐렴에서 골수 세포-1(TREM-1)에 발현된 트리거 수용체의 역할: 임상 연구의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-06-012022-09-11 Journal: Inflammopharmacology [Category] MERS, 바이오마커, [키워드] 95% CI analyzed Biomarker clinical study conducted contributing to controls coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Disease progression disease severity Diseases effect size elevated eligible evaluate Evidence expressed expression Google Scholar healthy healthy control healthy controls healthy individuals Human immune response infected patient infected patients Infection infections Inflammatory item marker material Meta-analysis Mild-to-moderate Mortality myeloid cells myeloid cells-1 no differences observational studies observational study outcome Patient patients with COVID-19 performed Pneumonia pneumonias PRISMA pro-inflammatory provided receptor Reporting review role SARS-CoV-2 severe COVID-19 severity shown significantly SMD standardized mean difference subgroup analysis systematic review systematic reviews the disease TREM-1 triggering Viral viral infections Viral pneumonia viral pneumonias viruses was performed were expressed [DOI] 10.1007/s10787-022-00972-6 PMC 바로가기 [Article Type] Meta-Analysis
The Role of Spirituality and Religiosity in Healthcare During the COVID-19 Pandemic: An Integrative Review of the Scientific LiteratureCOVID-19 팬데믹 기간 동안 의료에서 영성과 종교성의 역할: 과학 문헌의 통합 검토Review Published on 2022-06-012022-09-11 Journal: Journal of religion and health [Category] COVID19(2023년), SARS, 임상, [키워드] affecting Anxiety article Care carried caused Clinical practice Controlled trial coronavirus COVID-19 COVID-19 pandemic crisis database Depression Europe Faith Gray greater Health Health care healthcare Healthcare professional healthcare professionals help Hope increase in indicated individual Information System investigated literature mental health New coronavirus new coronavirus SARS-CoV-2 pandemic Patient satisfaction patients Population Previous studies previous study professional promote Quantitative Randomized controlled trial reduction in Religiosity Resilience resulting review role Spirituality Stress System Web of Science Well-being [DOI] 10.1007/s10943-022-01549-x PMC 바로가기 [Article Type] Review
Role of Serum Ferritin in Predicting Outcomes of COVID-19 Infection Among Sickle Cell Disease Patients: A Systematic Review and Meta-AnalysisArticle Published on 2022-05-302022-10-06 Journal: Front Med (Lausanne) [Category] 진단, [키워드] 95% CI Admission Analysis article Case series Cell Cochrane Library Cohort conducted COVID-19 COVID-19 infection critical appraisal database determine disease ferritin higher risk ICU ICU admission identify Joanna Briggs Institute marker Meta-analysis Mortality outcome Patient predict proportion ProQuest required review risk role SCD Serum ferritin serum ferritin level Severe COVID-19 Infection Sickle Sickle cell disease systematic review Web of Science WHO [DOI] 10.3389/fmed.2022.919159 PMC 바로가기 [Article Type] Article
Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infectionSARS-CoV-2 감염 후 급성 심폐 증상에서 항체, 염증 표지자 및 심장초음파 소견의 역할Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] Abnormalities age antibodies association baseline characteristics binding domain Biomarker Biomarkers breath C-reactive protein Cardiology Cardiopulmonary cardiovascular cardiovascular disease Cellular immune response chest pain COVID-19 cross-sectional analysis Dyspnea echocardiograms echocardiographic echocardiographic finding echocardiographic findings enrolled Evidence functional Hospitalization IgG antibody immune response individual Inflammation inflammatory markers investigation Logistic regression marker mechanism median median age occur palpitation palpitations parameter participant performed Receptor binding domain reported role SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 receptor Sex Shortness of breath Symptom Symptoms systemic inflammation women [DOI] 10.1172/jci.insight.157053 PMC 바로가기 [Article Type] Article