SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3Priority Research Paper Published on 2021-09-302022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] acute respiratory syndrome acute SARS-CoV-2 infection amplification amplified amplify cause causes Cell cells cellular senescence clinical trial contribute coronavirus COVID-19 died exacerbate Express Factor human cell human cells increase induce inhibiting inhibitor lung MHV mice morbidity mouse hepatitis virus Patient phenotype prevented pro-inflammatory Pseudotyped virus reported SARS-CoV-2 SASP senescence senescent senescent cell spike surface protein tlr-3 toll like receptor 3 Viral RNA was increased while β-coronavirus [DOI] 10.18632/aging.203560 PMC 바로가기 [Article Type] Priority Research Paper
Accumulation of CD28 null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 PatientsCD28 널 노화 된 T- 세포의 축적은 COVID19 환자의 불량한 결과와 관련이 있습니다.Review Published on 2021-09-292022-08-31 Journal: Biomolecules [Category] 바이오마커, 유전자 메커니즘, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse outcome adverse outcomes aging array Asymptomatic Cancer cause CD28 CD28null T-cells Cell chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) condition COPD coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID19 cytotoxicity death diabetes disease expansion hypertension immune decline individual Infection Infectious disease Inflammation inflammatory conditions morbidity and mortality mortality rates null cells obstructive pulmonary disease Patient populations potential mechanism potential mechanisms pulmonary disease respiratory Risk factors SARS-CoV-2 senescence senescent severe acute respiratory syndrome Coronavirus severity of COVID-19 Severity of infection Symptom T-cell T-cells Treatment underlying conditions [DOI] 10.3390/biom11101425 PMC 바로가기 [Article Type] Review
COVID-19 Immunobiology: Lessons Learned, New Questions AriseImmunology Published on 2021-08-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation Adaptive immune response adaptive immune system Asymptomatic autoantibody Autoimmune Autoimmunity cellular cellular senescence complement COVID-19 COVID-19 patient cytokine deregulation disease Diseases driven by endothelial Endothelitis Evidence Factor heterogeneity immune immune deregulation immunothrombosis Inflammation Inflammatory cell death Inflammatory response interferon lesson Mortality NET New offer pathophysiology phenotypic platelet activation responses SARS-CoV-2 senescence severe COVID-19 severe disease spatiotemporal subsequent the disease Treatment variety [DOI] 10.3389/fimmu.2021.719023 PMC 바로가기 [Article Type] Immunology
Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 InfectionHCN-2 세포의 전사체 분석은 SARS-CoV-2 감염 후 산화 스트레스, 노화 및 신경 세포 사멸 간의 연관성을 시사합니다Article Published on 2021-08-252022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis antioxidant Apoptosis blocking caspase caspase 3 CDK4 CDK6 CDKN2A Cell cell cycle cells cortical cell death decrease deregulation evaluate the effect explain followed by functions HCN-2 impairment increase in indicated KAT5 mechanism nervous system Neurological symptom Neurological symptoms Neuron neuronal neurons outcome oxidative stress pediatric PMAIP1 Potential treatment potential treatments Prevent PROTECT r death reduction reported required resulting ROS homeostasis SARS-CoV-2 SARS-COV-2 infection senescence SOD1 supported the cell Transcriptome transcriptomic analysis TXN upregulation virus western blot Western blot analysis [DOI] 10.3390/cells10092189 PMC 바로가기 [Article Type] Article
The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigmArticle Published on 2021-07-222024-09-02 Journal: Ageing research reviews [Category] 대상포진, [키워드] aging Geroscience hallmarks paradigm senescence theory [DOI] 10.1016/j.arr.2021.101407 PMC 바로가기 [Article Type] Article
Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis염증성 사이토카인 폭풍의 심각성은 COVID-19 바이러스 SARS-CoV-2와 같은 RNA 바이러스와 소핵의 상호 작용에 의해 촉진될 수 있습니다. 가설Review Published on 2021-07-012022-09-11 Journal: Mutation research. Reviews in mutation research [Category] SARS, 변종, 유전자 메커니즘, [키워드] affected Aneuploidy Cell cGAS cGAS-STING. chromosomal instability COVID-19 COVID-19 virus cyclic GMP cytokine production Cytokine storm Effect elevated Evidence Factor Frequency high risk Hypothesis immune response immunologically increase individual induce Infection Inflammation Inflammatory cytokine inflammatory cytokine production Interaction interferon leakage lymphocyte mechanism Micronuclei moderate observation pro-inflammatory cytokine pro-inflammatory response reduction RNA RNA virus RNA viruses SARS-CoV-2 SASP secretory senescence Senescence Associated Secretory Phenotype severity stimulator STING susceptible threshold tissue damage virus infection viruses weakened [DOI] 10.1016/j.mrrev.2021.108395 PMC 바로가기 [Article Type] Review
Endothelial Senescence and Chronic Fatigue Syndrome, a COVID-19 Based HypothesisCellular Neuroscience Published on 2021-06-252022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] Abnormalities bacterial lipopolysaccharide Blood Brain cellular senescence characterized chronic COVID-19 COVID-19 pandemic disrupting Endothelial cell endothelial cells endotoxin tolerance etiology fatigue gastrointestinal tract Gut gut microbial community host protein impairment Infection Interaction intestinal memory microbe microbial microbial translocation other tissues Pain Pathogenesis Patient Premature promoted resulting senescence supported Symptom syndrome the SARS-CoV-2 the SARS-CoV-2 virus tiredness translocation triggered [DOI] 10.3389/fncel.2021.673217 PMC 바로가기 [Article Type] Cellular Neuroscience
Aging versus youth: Endocrine aspects of vulnerability for COVID-19Article Published on 2021-04-162023-06-15 Journal: Reviews in Endocrine & Metabolic Disorders [Category] COVID19(2023년), MERS, SARS, [키워드] Aging, biological COVID-19 endocrine system Immunity SARS-CoV-2 senescence [DOI] 10.1007/s11154-021-09656-y PMC 바로가기 [Article Type] Article
Influence of the microenvironment on modulation of the host response by typhoid toxin장티푸스 독소에 의한 숙주 반응 조절에 대한 미세환경의 영향Article Published on 2021-04-062024-08-21 Journal: Cell Reports [Category] 살모넬라증, [키워드] Ataxia-telangiectasia mutated (ATM) bacterial genotoxins Colitis immune response immunomodulation microenviroment senescence typhoid toxin
The aging lung: Physiology, disease, and immunityReview Published on 2021-04-022023-06-15 Journal: Cell [Category] Fulltext, MERS, [키워드] aging COPD COVID-19 healthspan Immunity inflammaging lung lung cancer metabolism oxidative stress Proteostasis pulmonary fibrosis senescence stress response [DOI] 10.1016/j.cell.2021.03.005 PMC 바로가기 [Article Type] Review