An mRNA-based vaccine candidate against SARS-CoV-2 elicits stable immuno-response with single doseSARS-CoV-2에 대한 mRNA 기반 백신 후보는 단일 용량으로 안정적인 면역 반응을 이끌어냅니다.Article Published on 2021-06-232022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] animal model antibody architecture CD4+ cell CD4+ cells characterization clinic coronavirus COVID D614G D614G variant domain dose elicit Extracellular Formulation Genotype HEK293 cell HEK293 cells IgG immunization immunized mice immunologic response immunologic responses implicated Infection Lipid Lipid nanoparticle LNP mRNA-based vaccine neutralized product provide pseudoviruses purified RBD responsible SARS-CoV-2 SARS-CoV-2 virus single dose Spike protein SPR stable population suggested surface plasmon surface plasmon resonance Th1 the spike protein translation vaccination Vaccine vaccine candidate [DOI] 10.1016/j.vaccine.2021.05.035 PMC 바로가기 [Article Type] Article
Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and PerspectivesReview Published on 2021-06-192022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Analysis challenge collected coronavirus coronavirus disease COVID-19 detection develop diagnose Direct effective Effectiveness ENhance Epidemic Google Scholar healthcare help hospitals identify include Infection laser diagnosis techniques light–matter interaction Optical biosensor pandemic photonics PubMed Central reducing researcher scattering Science SPR surface viral disease virus viruses Web of Science [DOI] 10.3390/diagnostics11061119 PMC 바로가기 [Article Type] Review
sMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral Responses in SARS-CoV-2 InfectionsMAdCAM: IL-6 비율은 SARS-CoV-2 감염에서 질병 진행 및 항바이러스 반응에 영향을 미칩니다Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] Anti-viral antibodies antibodies binding Antibody test association binding carried chemiluminescent immunoassay Cohort convalescent convalescent individual convalescent individuals correlated COVID-19 COVID-19 disease COVID-19 pathogenesis cytokine Cytokines Diagnosis disease Disease progression exhibiting expressed Fold change Gut highest highlight homing humoral IgG IgM IL-6 immune Immunity in-patient In-patients incrementally India infected individual Infection Inflammation influence Intervention investigated marker mediators Mumbai parameter persistence plasma Plasmon profile progression Prophylactic rapid antibody test Ratio Receptor binding domain recruited resonance response SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins significantly higher sMAdCAM sMIL index specific immunity SPR Stage surface surface plasmon surface plasmon resonance systemic inflammatory therapeutic virus were measured [DOI] 10.3389/fimmu.2021.619906 PMC 바로가기 [Article Type] Immunology
Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infectionsReview Published on 2021-06-022022-10-27 Journal: Biophysical Reviews [Category] COVID-19, [키워드] advance Analysis biological marker body fluids carried COVID-19 Fourier transform FTIR group health condition highlight HPLC-LIF Human increase in Infection medical diagnostics Non-invasive offer optical personal health photonics Raman spectroscopy recent Saliva SERS specimen SPR treated viral infection [DOI] 10.1007/s12551-021-00807-8 PMC 바로가기 [Article Type] Review
SPR Perspectives: scientific opportunities in the Environmental influences on Child Health Outcomes Program Research Published on 2021-05-252022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] Child childhood Critical determinant Drawing feature Follow-up Health Impact inaccessible influences on investigator lack large sample limited sample size methodological methodology Participants pediatric pediatric cohort Program question Research Research question researcher resource SPR The United States unique [DOI] 10.1038/s41390-021-01577-5 [Article Type] Research
Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus신종 코로나바이러스의 신속한 검출을 위한 그래핀 코팅 SPR 바이오센서의 설계 및 수치 분석Article Published on 2021-05-172022-09-10 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, [키워드] Accuracy added addition Algorithm Analysis analyte analyzed Anti-spike biosensor changed checked coated Concentration coronavirus COVID-19 COVID-19 virus detection Detection sensitivity Diagnosis excitation expected False positive figure Frequency Graphene IgG IgM Interaction investigated Ligand mAbs molecular detection monoclonal antibodies monoclonal antibody novel Novel coronavirus offer pandemic probe Protein provide quality factor Rapid rapid detection RBD Receptor-binding domain reduce refractive index Ribonucleic acid RNA SARS-CoV-2 sensitivity sensor spike receptor-binding domain SPR Spread surface plasmon surface plasmon resonance Total Internal Reflection transfer two-dimensional Viral Viral RNA virus Virus spike were used [DOI] 10.3390/s21103491 PMC 바로가기 [Article Type] Article
Biosensors as a future diagnostic approach for COVID-19Review Published on 2021-05-152023-06-19 Journal: Life sciences [Category] MERS, SARS, [키워드] ACE2 receptors Bioreceptors COVID-19 electrochemical rapid detection SARS-CoV-2 Spike proteins SPR Viral biosensor. [DOI] 10.1016/j.lfs.2021.119117 PMC 바로가기 [Article Type] Review
The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CL pro In VitroArticle Published on 2021-05-102022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 3CL pro 3CLpro Amino acid antiparasitic approved AstraZeneca binding clinically Combination confirmed case COVID-19 COVID-19 disease COVID-19 vaccines demonstrated described disease docking drug drug candidate drug combination drugs effective Efficacy eight Emergency use experiment identify inhibit SARS-CoV-2 inhibitory Interaction interactions involved Johnson & Johnson magnitude main protease moderate Moderna molecular offer pandemic Pfizer-BioNTech Pneumonia quinacrine reported Repurposing approved drugs resulting Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 main protease SARS-CoV-2 protein SPR Spread suggested Suramin surface plasmon resonance synergistic the WHO therapeutic treat Treatment Vaccine variant Wuhan, China [DOI] 10.3390/v13050873 PMC 바로가기 [Article Type] Article
Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approachACE2/CMC-HPLC-IT-TOF-MS 접근법에 의한 Ephedra sinica의 anti-SARS-CoV-2 성분 스크리닝 및 평가Article Published on 2021-05-012022-08-31 Journal: Analytical and bioanalytical chemistry [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 receptor Amino acid amino acid residues anti-SARS-CoV-2 approach binding binding assay Binding assays blocker blockers CCK-8 Cell Cell membrane chromatography cells Characteristics China Chinese component Compound compound screening compounds COVID-19 Ephedra sinica Ephedra sinica. ephedrine evaluate feature fraction HPLC inhibit inhibiting Medicine membrane methylephedrine molecular docking observé performed pseudoephedrine pseudovirus reduce SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike screened Screening separated SPR staining surface plasmon surface plasmon resonance Toxicity Traditional Traditional Chinese medicine traditional Chinese medicines treat Treatment treatment of COVID-19 viropexis [DOI] 10.1007/s00216-021-03233-7 PMC 바로가기 [Article Type] Article
Repositioning of histamine H 1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2히스타민 H 1 수용체 길항제의 재배치: Doxepin은 ACE2를 차단하여 SARS-CoV-2 Spike pseudovirus의 viropexis를 억제합니다Article Published on 2021-04-052022-09-11 Journal: European journal of pharmacology [Category] SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antagonist anti-SARS-CoV-2 antiviral effects caused Cell clinical trials CMC coronavirus COVID-19 demonstrated Doxepin drug drug candidate drug repositioning Drug repurposing effective drug effective drugs enzyme feasible FIVE global health Health HEK293T cell help Histamine Histamine H(1) receptor antagonist Infection infection rate inhibit inhibit SARS-CoV-2 Interaction membrane outbreak overexpressing pandemic provide pseudovirus receptor receptor antagonist reducing reported repositioning SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus spike SPR Spread surface plasmon surface plasmon resonance Vaccine virus Virus Disease [DOI] 10.1016/j.ejphar.2021.173897 PMC 바로가기 [Article Type] Article