KL-MOB: automated COVID-19 recognition using a novel approach based on image enhancement and a modified MobileNet CNNBioinformatics Published on 2021-09-202022-10-29 Journal: PeerJ Computer Science [Category] COVID-19, [키워드] Accuracy adopted Algorithm applied approach automated breathed Chest CNN contrast enhancement Convolution country COVID-19 COVID-19 cases COVIDx dataset detect develop Health help IMPROVE infected patient KL-MOB Noise reduction Novel coronavirus pandemic Patient Pneumonia Precision researcher researchers returned sensitivity specificity starting point The Kullback–Leibler divergence loss function Vaccine X-ray [DOI] 10.7717/peerj-cs.694 PMC 바로가기 [Article Type] Bioinformatics
Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9SARS-CoV-2 비구조 단백질 9에 대한 피리미딘 RNA 염기 모방체의 결합Article Published on 2021-09-012022-09-11 Journal: The Journal of Biological Chemistry [Category] Coronavirus, SARS, 치료법, [키워드] association complex component Compound contribute Coronaviral domain engage form fragment screen homodimer induce Interaction mechanism motif Nsp9 oligomerization oligonucleotide binding probe Protein recruit replicase replicase. RNA SARS-CoV-2 SARS-CoV-2 replication seeking small molecule Stage starting point Transcription viral replication Viral RNA [DOI] 10.1016/j.jbc.2021.101018 PMC 바로가기 [Article Type] Article
Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy이탈리아의 초기 전염병 기간 동안 COVID-19 환자의 치명적인 결과와 관련된 독특한 대사 프로필Observation Published on 2021-09-012022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 바이오마커, 진단, [키워드] alteration best change clinical condition Cohort Complete contribute coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients described Diagnosis diagnostic disease severity epicenter Fatal outcome identify independent Infection IRCCS Italian Italy lombardy metabolic metabolome metabolomics moderate moment mortality rate not correlated outcome oxygen oxygen demand pandemic Potential biomarker potential biomarkers predictive biomarkers profile Prognosis Prognostic factor Region SARS-COV-2 infection severe cases severe symptom severity starting point the disease the patient therapeutic Therapeutic treatment understanding unique [DOI] 10.1128/Spectrum.00549-21 PMC 바로가기 [Article Type] Observation
Common contributing factors to COVID-19 and inflammatory bowel diseaseCOVID-19 Pandemic: Health impact and Novel research Published on 2021-08-312022-10-04 Journal: Toxicology Reports [Category] 바이오마커, 유전자 메커니즘, [키워드] Abstract acute respiratory syndrome approach biologic candidate Chronic diseases common Complication contribute Contributing factors coronavirus coronavirus disease COVID-19 Crohn’s disease Crohn’s disease demonstrated disease Diseases dysfunctional immune system event Factor Factors Government Health IBD identify immune dysfunction immune function immune response immune system Immune system dysfunction Impact impacted impair Infection Inflammatory bowel disease initial LRDI Multiple overlap overlapping pandemic psychosocial stressors representing Result SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome starting point Stressor toxic substance Treatment ulcerative colitis was used with COVID-19 [DOI] 10.1016/j.toxrep.2021.08.007 PMC 바로가기 [Article Type] COVID-19 Pandemic: Health impact and Novel research
SARS-CoV-2 in diabetic pregnancies: a systematic scoping reviewResearch Published on 2021-08-212022-10-28 Journal: BMC Pregnancy and Childbirth [Category] COVID-19, MERS, [키워드] ACE2 adverse effect approach approaches assumed Care carried changes in CINAHL clinical diabete clinical implication Clinical management Clinical outcome Cochrane Library Collection complex interplay consequence core Course COVID-19 diabete diabetes Diabetes Mellitus Diabetic Digital effective Enzymes Epidemiology Epigenetic Evidence Features fetal gestation group hypoxemic hypoxia increased risk Interaction management mechanism Modification mother Neonatal outcomes pandemic pathophysiological mechanism platelet activation pregnancies Pregnancy pregnant women pro-inflammatory cytokines Prognosis recommendation Result SARS-CoV-2 starting point supplementary material systematic review the SARS-CoV-2 Transmission treat Web of Science women [DOI] 10.1186/s12884-021-03975-3 PMC 바로가기 [Article Type] Research
SARS-CoV-2 Threat Perception and Willingness to Vaccinate: The Mediating Role of Conspiracy BeliefsPsychology Published on 2021-08-192022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] acute respiratory syndrome addressed age belief conspiracy beliefs coronavirus coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine Demographic variables exploratory study expressed Factor Gender indicated investigated Mediating no significant difference Novel coronavirus participant Participants Perception planned behavior Psychological public health communication rejection role SARS-CoV-2 starting point suggested tested threat Threat perception vaccinate Vaccination hesitancy Vaccine [DOI] 10.3389/fpsyg.2021.672634 PMC 바로가기 [Article Type] Psychology
Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2SARS-CoV-2에 대한 항바이러스 활성에 대한 FDA 승인 및 생리활성 화합물 라이브러리 스크리닝Article Published on 2021-08-132022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 신약개발, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus anti-inflammatory activity Antiviral antiviral activity antivirals approved assays B02 causative agent combination therapies combination therapy Compound compound screening coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical death demonstrated drug Drug repurposing effective epithelial cells exhibit FDA Health highlight highlighting Host identify include inhibitor kinase kinases library mono pathway protease Proteases Rad51 Remdesivir reported Safe SARS-CoV-2 SARS-CoV-2 replication Screening Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point synergy therapeutic options treat [DOI] 10.1021/acsinfecdis.1c00017 PMC 바로가기 [Article Type] Article
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicaseArticle Published on 2021-08-112022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] Analysis Anti-viral Antiviral agents apo form ATP conformational change conserved COVID-19 pandemic crystal structure dataset drug target effective drug Helicase help identify in viral infected with SARS-CoV-2 lack mechanism Molecular medicine performed phosphate Protein Replication reveal SARS-CoV-2 SARS-CoV-2 nsp13 SARS-CoV-2 proteome Sequence conservation starting point structural biology Structure the SARS-CoV-2 treat viral replication X-ray crystallography [DOI] 10.1038/s41467-021-25166-6 PMC 바로가기 [Article Type] Article
Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 proteaseTheobroma cacao L. 화합물: 주요 SARS-CoV-2 프로테아제 억제제로서의 이론적 연구 및 분자 모델링Article Published on 2021-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료제, [키워드] acute respiratory syndrome alanyl antioxidant binding binding efficiency Bioflavonoids carbonyl cause chemical property Cocoa bean complex Compound coronavirus COVID-19 DFT enzyme evaluated free energy Free energy calculation Free energy calculations high affinity in silico in vitro in vivo experiment inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 Ligand molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations naringin performed presenting protease Quantum mechanics rutin SARS-CoV-2 SARS-CoV-2 protease Severe acute respiratory syndrome starting point Structural analysis Theobroma cacao Theobroma cacao. [DOI] 10.1016/j.biopha.2021.111764 PMC 바로가기 [Article Type] Article
Molecular docking, binding mode analysis, molecular dynamics, and prediction of ADMET/toxicity properties of selective potential antiviral agents against SARS-CoV-2 main protease: an effort toward drug repurposing to combat COVID-19분자 도킹, 결합 모드 분석, 분자 역학 및 SARS-COV-2 주요 프로테아제에 대한 선택적 전위 항 바이러스제의 ADMET/독성 특성의 예측 : CovID-19에 대항하기위한 약물 용도를 향한 노력Article Published on 2021-08-012022-08-31 Journal: Molecular diversity [Category] SARS, 신약개발, 치료제, [키워드] active site Amino acid amino acid residue amino acid residues Analysis Antiviral antiviral agent Antiviral agents antiviral drug antiviral molecules ARB Arbidol AutoDock binding carried Chloroquine complex COVID-19 crystal structure Cys145 digestion direction docking Docking studies docking study drug design Drug discovery drug target Dynamics/simulation study effort enzyme exhibited FDA-approved drug FDA-approved drugs Glu166 glycyrrhizin GS441524 HCQ HIS163 Hydroxychloroquine in silico indicated inhibitory Interaction lead Ligand M pro mechanism molecular molecular docking molecular docking studies Molecular docking study molecular dynamics molecules MPro not need polyprotein Potential Potential antiviral agents present protease Protein provide RDV reason reason for Remdesivir RMSD SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 main protease (Mpro). selected selective stability starting point starting points suggested tested Toxicity Viral [DOI] 10.1007/s11030-021-10188-5 PMC 바로가기 [Article Type] Article