Stimulation – Page 5 – Communicable Diseases Research

Cellular and humoral immunogenicity of a SARS-CoV-2 mRNA vaccine in patients on haemodialysis

혈액투석 환자에서 SARS-CoV-2 mRNA 백신의 세포 및 체액 면역원성

Article

Published on 2021-08-012022-09-11
Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단,

Detection of IFNγ-Secreting CD4 + and CD8 + Memory T Cells in COVID-19 Convalescents after Stimulation of Peripheral Blood Mononuclear Cells with Live SARS-CoV-2

살아있는 SARS-COV-2를 갖는 말초 혈액 단핵 세포의 자극 후 COVID-19 COVALESCERS에서 IFNγ- 분비 CD4 + 및 CD8 + 메모리 T 세포의 검출

Brief Report

Published on 2021-07-292022-09-10
Journal: Viruses [Category] SARS, 치료기술,

[키워드] causative agent CCR7 CD4 CD45 CD45RA CD8 Cell Cellular immune response cellular immune responses Characteristics circulating circulation collected convalescent coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 convalescents COVID-19 pandemic Cytotoxic T cell Cytotoxic T cells detection effector memory Epitopes flow cytometry Human IFNγ Immune cell immune cells immune responses Immunity information intracellular cytokine staining live SARS-CoV-2 memory T-cell response memory T-cell responses Multiple Multiple studies natural infection New New coronavirus new coronavirus SARS-CoV-2 PBMC PBMCs peptide peptide pool peptide pools peptides peripheral persistence phenotype pool Quantitative SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines significant level Stimulation sucrose T cell T cells T-cell T-cell epitopes T-cell immunity T-cell memory T-cell responses T-helper long-lived immunity the disease These data Viral Viral proteins
[DOI] 10.3390/v13081490 PMC 바로가기 [Article Type] Brief Report

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’

단일 세포 RNA 시퀀싱은 '역 표현형'을 통해 SARS-CoV-2 반응성 T 세포의 생체 외 서명을 밝힙니다.

Article

Published on 2021-07-262022-09-10
Journal: Nature Communications [Category] SARS, 진단, 치료기술,

[키워드] absence activated Activation acute respiratory syndrome Antigen antigenic antigenic stimulation approach cellular cellular immunity characterisation cohorts Conventional coronavirus disease Coronavirus disease 2019 correspondence COVID-19 detect Ex vivo high resolution human leukocyte antigen identify immune response in vitro in vivo independent induce Infection introduced leukocyte Patient patients phenotype Phenotypes phenotypic phenotypic effect powerful tool presence or absence provide reactive respiratory respiratory tract reveal RNA sequencing SARS-CoV-2 sequence sequences Severe acute respiratory syndrome severe disease Single Cell Single-cell RNA sequencing Stimulation T cell T cell receptor T cell response T cells T-cell receptor TCR TCRs the SARS-CoV-2 tissue tissues transcriptional viral infection virus
[DOI] 10.1038/s41467-021-24730-4 PMC 바로가기 [Article Type] Article

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

심한 Covid-19를 가진 젊고 이전에 건강한 남성의 TLR7 변이체에 대한 유전자 스크리닝

Clinical Trial

Published on 2021-07-232022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단,

[키워드] absence age blood cell Blood cells coding region Comorbidities Comorbidity COVID-19 database deficiency Deleterious determine Diagnosis Genetic genetic screening High-flow nasal oxygen host genetics imiquimod immunodeficiency in silico interferon interferon response IQR loss-of-function male median age men Mild missense variant oxygen Patient pre-symptomatic predicted predictors predisposition prospectively studied rare variant rationale reported required Result Risk factors SARS-CoV-2 Screening sequenced severe COVID-19 Stimulation Support the median the patient therapeutic interventions TLR7 treat Treatment type I underlie variant variants
[DOI] 10.3389/fimmu.2021.719115 PMC 바로가기 [Article Type] Clinical Trial

Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness

혈장 1,3-β-d-글루칸 수치는 중환자에서 불리한 임상 결과를 예측합니다

Clinical Medicine

Published on 2021-07-222022-09-10
Journal: JCI Insight [Category] SARS, 바이오마커,

[키워드] Acute respiratory failure adjusted Analysis ARF association Award Biomarker cell wall circulation clinical Clinical outcome collected COVID-19 Critical Critical illness Critically ill Critically ill patient critically ill patients Cytokines enrolled epithelial epithelial permeability fungal fungal cell wall Fungal infection fungal infections fungi Gut healthy controls higher odd higher odds hospitalized patient Host host inflammatory response Hyperinflammatory Infectious disease Inflammation Inflammatory responses information Innate immunity invasive lung mechanically ventilated patient mechanism median Microbiology NIH offer offered outcomes pathogen pathogen-associated molecular Patient Pittsburgh plasma plasma samples predict Predictive prognostic Research Respiration Respiratory failure Science significantly higher stimulate Stimulation suggested survival systemic circulation therapeutic translocation university ventilator-free day with COVID-19
[DOI] 10.1172/jci.insight.141277 PMC 바로가기 [Article Type] Clinical Medicine

Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology

SARS-CoV-2 항체 혈청 검사가 음성인 회복기 COVID-19 환자의 반응성 T 세포

Immunology

Published on 2021-07-122022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료기술, 치료법,

[키워드] analyzed Antibody Response CD4+ T cell convalescent convalescent COVID-19 patient convalescent individuals convalescent patient Convalescent patients coronavirus Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patients cytokine detectable disease course elicited Endemic flow cytometry Frequency HCoV HCoV-229E healthy control healthy controls human endemic coronavirus 229E (HCoV-229E) human endemic coronavirus OC43 (HCoV-OC43) IFN IL-2 Mild negative nucleocapsid peptide peptide pool persistence positive question raise reactive RT-PCR SARS-CoV-2 SARS-CoV-2 spike seronegative seropositive serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibodies specific antibody Stimulation T cell T cell response T cells TNFα undetectable Viral viral control
[DOI] 10.3389/fimmu.2021.687449 PMC 바로가기 [Article Type] Immunology

Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity

선천 면역 자극을 통한 시험관 내 SARS-CoV-2 복제에 대한 인플루엔자 A 바이러스 결함 간섭 입자의 항바이러스 활성

Communication

Published on 2021-07-112022-09-11
Journal: Cells [Category] SARS, 변종, 치료제,

[키워드] abrogation activity acute respiratory syndrome acute respiratory syndrome coronavirus Administered Antiviral antiviral activity antiviral agent Antiviral treatment applicability approved Cell Cell culture Co-infection Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 defective interfering particles dependent on DI244 DIP disease effective Efficacy experiment human lung cells IAV Immune escape in vitro Influenza influenza A influenza A virus inhibitory effect Innate Innate immunity interferon JAK/STAT janus Janus kinase leads OP7 pandemic Particle Replication respiratory Respiratory virus infections SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT Stimulation Transcription Treatment treatment of COVID-19 Vaccine vaccine availability variant variants of SARS-CoV-2 virus virus infections
[DOI] 10.3390/cells10071756 PMC 바로가기 [Article Type] Communication

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

Immunology

Published on 2021-06-252022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] 48 hour ACE2 ANPEP Apoptosis Autoimmune disease cancers cardiovascular comorbidity cardiovascular disease CEACAM1 cell death changes in complexes contribute controls coronavirus Coronavirus infection Coronaviruses COVID-19 CSF1 CSF3 CVD Cytokine storms DAMP DAMPs dataset death DPP4 Endothelial cell enzyme Epigenetic ER stress examined Express expressed expression facilitate Factor Ferroptosis hours post-infection Human hyperlipidemia IL6 Immunity Inflammation innate immune innate immune responses LPS majority marker MERS-CoV Microarray mitochondrial mitotic modulated monocyte Myelopoiesis Nrf2 nucleic acid oxidative phosphorylation PAMP Proinflammatory cytokine Proinflammatory response protein complex pyroptosis receptor regulate ROS stimulated Stimulation storm Stress subsequent Thromboembolism thrombosis TMPRSS2 TNFα trained immunity transcriptomic upregulated upregulation Viremia virus entry
[DOI] 10.3389/fimmu.2021.653110 PMC 바로가기 [Article Type] Immunology

Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine

Article

Published on 2021-06-162022-10-29
Journal: Scientific Reports [Category] Coronavirus,

[키워드] Activation Analysis Biomarker Cell dendritic cell differentially expressed domains eight facilitated Gene regulation in immune cells homology immune responses in vivo inactivated Inactivated vaccine increased expression Infectious Bronchitis Virus Innate immune cells lipid metabolism lysed maturation mRNA mRNA expression mRNA translation newcastle disease virus PLIN2 positive control Potential biomarker Protein protein level Proteins proteomic Proteomic analysis provide PSMB1 significantly stimulated Stimulation subject the vaccine upregulated Vaccine vaccine-induced immune responses Vaccines were assessed
[DOI] 10.1038/s41598-021-89810-3 PMC 바로가기 [Article Type] Article

Targeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19

심각한 CovID-19를 예방하기위한 치료 전략으로서 CD80/86 전 염증 축의 표적화

Article

Published on 2021-06-012022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 임상, 진단, 치료법, 치료제,

[키워드] abatacept analyzed antagonistic block Blood blood sample Blood samples Bronchoalveolar lavage fluid CD80 change China Cohort controls COVD-19 patients COVID-19 COVID-19 case COVID-19 severity COVID19 cytokine Cytokine storm drug effective elicited epicenter epidemiological Evidence excessive immune response exploratory functional hallmark hyperinflammation immunological Inflammatory diseases Mild pandemic patient cohorts patients treated Prevent proinflammatory PROTECT regulated RNA-Seq SARS-COV-2 infection severe COVID-19 severe COVID-19 patient Signaling significantly single-cell RNA-seq Stimulation Support systemic level Target identification targeting Therapeutic approach therapeutic strategy Treatment USA viral infection
[DOI] 10.1038/s41598-021-90797-0 PMC 바로가기 [Article Type] Article