Neuromodulation for Craniofacial Pain and HeadachesReview Published on 2023-12-162024-09-04 Journal: Biomedicines [Category] 대상포진, [키워드] Cluster Facial Pain headache migraine neuralgia neuromodulation Stimulation [DOI] 10.3390/biomedicines11123328 PMC 바로가기 [Article Type] Review
Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trialArticle Published on 2022-10-132022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome antibody approved blood sample Brazil CD4 cellular Chilean China circulating antibodies clinical clinical trial Concentration CoronaVac coronavirus coronavirus disease correlation COVID-19 difference dose Efficacy elicited Emergency use enrolled evaluate evaluated exhibited expression flow cytometry healthy Human humoral immune response humoral immune responses IFN-γ immune response immunization immunogenicity data immunology inactivated Indonesia Inflammation interferon marker Medicine Ministry of Health mononuclear cell multicenter neutralizing antibody neutralizing capacity pandemic PBMCs performed Peripheral blood Phase 3 phase 3 clinical trial phase 3 trial Production progression promote Randomized reported robust Sample SARS-CoV-2 SARS-CoV-2 vaccine secretion separated single center Stimulation T cell Trial Turkey Vaccine Vaccines variants of concern virus VOCs Volunteer were assessed [DOI] 10.7554/eLife.81477 PMC 바로가기
Circulating B10 regulatory cells are decreased in severe and critical COVID-19심각하고 치명적인 COVID-19에서 순환하는 B10 조절 세포가 감소합니다Article Published on 2022-08-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] B cell B cells B10 Bregs Cell cells clinical and laboratory parameters correlated COVID-19 COVID-19 pathogenesis Critical critical COVID-19 patient determine disease severity evaluate Evidence explained Frequency functional healthy individuals IL-10 immune response immune responses include inflammatory parameter Laboratory parameters mechanisms multiparametric flow cytometry patient groups PBMC PBMCs reduction in Regulatory regulatory cell SARS-CoV-2 severity specific antibodies specific antibody Stimulation subset the disease [DOI] 10.1002/JLB.5COVCRA0721-387RR PMC 바로가기 [Article Type] Article
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies이종 saRNA 프라임, DNA 이중 항원 부스트 SARS-CoV-2 백신 접종으로 강력한 세포 면역원성과 교차 변형 중화 항체 유도Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Adenovirus animal model animal models B.1.617.2 Beta boost CD4+ CD8+ T-cell combinations COVID-19 D614G mutation Delta distribution DNA dual dual antigen ENCODE enhanced expression followed by furin furin cleavage region Glutamine Heterologous highest homologous homologous or heterologous Humoral response humoral responses IgG immune response immune responses immunogenicity lipid carrier MHC class I MHC class I and II mice motif N antigen Neutralizing nucleic acid nucleocapsid omicron peptide peptides prefusion conformation prime proline prolines protease pseudovirus receiving regimen regimens Region response RNA vaccine SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant self-amplifying RNA sequence sera serotype spike Stimulation strain Strains Support T-cell T-cell responses vaccination Vaccine Vaccines variant wild type Wuhan [DOI] 10.3389/fimmu.2022.910136 PMC 바로가기 [Article Type] Article
Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19혈소판 활성화 및 부분 탈감작은 중증 COVID-19 환자의 바이러스 이종과 관련이 있습니다Article Published on 2022-07-122022-09-11 Journal: Blood advances [Category] COVID19(2023년), SARS, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Alter assays autophagy Bacterial sepsis changes in Combination Complication coronavirus Critically ill critically ill patients Cytokines decrease develop exhibited flow cytometry fraction Gene Expression GPVI healthy healthy donor healthy donors immunofluorescence indicated infected patient infected patients intensive care intensive care unit interactions intracellular vesicle investigated labeling leukocyte Localization lung marker mass spectrometry Microscopy Nucleocapsid proteins parameter Patient patients with COVID-19 plasma Platelet platelet activation platelet aggregation platelet-rich thrombi Platelets Proinflammatory cytokine proinflammatory cytokines prospective cohort Protein reduction SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles secretion selective Sepsis severe acute respiratory syndrome Coronavirus severe COVID-19 shown spike Stimulation Structure Tandem mass spectrometry These data thrombi thrombocytopenia transmission electron microscopy Xenophagy [DOI] 10.1182/bloodadvances.2022007143 PMC 바로가기 [Article Type] Article
Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine StimulationDiscovery Proteomics 분석을 통해 드라이버 종양유전자가 인터페론-β 자가분비 자극 감소를 통해 항바이러스 방어 경로를 억제한다는 사실이 확인되었습니다.Article Published on 2022-07-012022-09-11 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activated AKT Antiviral approach autocrine BRAF c-MYC Cancer cancer cell line cancer cell lines cancers Cell cell line cellular DDX58 develop double-stranded double-stranded RNA downregulation driven by driving dsRNA EGFR expression functional hallmark HER2 immune evasion Infection interferon KRAS lower expression MEK molecular MYC OAS oncogene oncogenes. oncogenic osteosarcoma Pancreatic cancer phenotypic profiles Protein Proteins proteome provide reduced regulated response RIG-I RNA virus SARS-CoV-2 shown Stimulation susceptibility susceptibility to infection therapeutic treated type 1 interferon [DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article
T-cell proliferation assay for the detection of SARS-CoV-2-specific T-cellsSARS-CoV-2-특이적 T-세포 검출을 위한 T-세포 증식 분석Article Published on 2022-07-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] an area Analysis antibody approved AUC B-cell B-cell response blood sample Blood samples carried cellular cellular immune responses clinical setting clinical settings complex Control control group controls ELISA assay False positive False positives Health care Health care worker health care workers humoral Humoral and cellular immune responses IgG immune immune responses Immunoglobulin Immunoglobulin G Infection less lymphocyte lymphocyte transformation Lymphocyte transformation test majority membrane N and M non-infected nucleocapsid peptide peptide pool peptide pools proliferation Protein representing resulting ROC analysis S protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein Spike protein Stimulation T-cell T-cell Response T-cell responses the S protein the S1 subunit the SARS-CoV-2 thymidine Trigger vaccinated individual vaccination Vaccines were recorded [DOI] 10.1016/j.cca.2022.05.025 PMC 바로가기 [Article Type] Article
Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다Article Published on 2022-06-282022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used [DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article
Status of Humoral and Cellular Immune Responses within 12 Months following CoronaVac Vaccination against COVID-19COVID-19에 대한 CoronaVac 백신 접종 후 12개월 이내에 체액 및 세포 면역 반응의 상태Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 12 months addition antibody approved baseline binding binding and neutralizing antibodies binding antibodies binding antibody CD4 CD8 Cell Cellular immune response cellular response Cellular responses central memory CoronaVac country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Critical declined detectable dose effector memory Emergency use Endpoint enrolled Evidence functional gamma interferon granzyme B GzmB humoral Humoral and cellular immune responses IFN-γ IL-2 IL-5 immune memory immune persistence immune responses Inactivated vaccine interleukin interleukin 2 memory T cell memory T cells Month Neutralizing antibodies neutralizing antibody neutralizing antibody responses participant persistence produced provide RBD Receptor-binding domain reported response SARS-CoV-2 SARS-CoV-2 RBD second dose secretion seroconversion rate seropositive significantly higher status Stimulation T cells the cells the receptor-binding domain understanding vaccination vaccination schedule Vaccination strategy Vaccine [DOI] 10.1128/mbio.00181-22 PMC 바로가기 [Article Type] Article
Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination Research Published on 2022-06-012022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] adjusted Blood Ccr6 CD107a CD4+ cell CD4+ T cell CD8+ T cell Cell clinical trials contribute COVID-19 vaccination COVID-19 vaccine Cytokines decrease Donor doses Efficacy elevate expansion expressing expression flow cytometry increase in increases in less linear memory mRNA nasal nasal mucosa Pfizer-BioNTech phenotype protective immunity SARS-CoV-2 SARS-CoV-2 spike peptide second dose shown Stimulation subset Swab T cell upper respiratory tract vaccination Vaccine vaccine dose Vaccines [DOI] 10.1038/s41467-022-30913-4 [Article Type] Research