STING or Sting: cGAS-STING-Mediated Immune Response to Protozoan Parasitesarticle Published on 2020-09-302024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] cGAS malaria parasite infection STING type I IFN response [Article Type] article
The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infectionArticle Published on 2020-09-042023-07-01 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, [키워드] ACE2, angiotensin-converting enzyme 2 ARDS, acute respiratory distress syndrome BTK, Bruton’s tyrosine kinase CAR, Chimeric antigen receptor COVID-19 COVID-19, Coronavirus disease 2019 CP, convalescent plasma CRP, C-reactive protein CRS, Cytokine release syndrome CS, cytokine storm Cytokine storm Cytokines FDA, Food and Drug Administration hemophagocytic lymphohistiocytosis HLH, Hemophagocytic lymphohistiocytosis Hyperinflammatory IL-6 Jak JAK, Janus-associated kinase MAS, macrophage activation syndrome MERS-CoV, MERS coronavirus MERS, Middle East respiratory syndrome proinflammatory SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, SARS Coronavirus Sepsis STING STING, Stimulator of IFN genes TNF-α [DOI] 10.1016/j.jaci.2020.07.001 PMC 바로가기 [Article Type] Article
Reactive oxygen species oxidize STING and suppress interferon productionarticle Published on 2020-09-042024-09-02 Journal: eLife [Category] 대상포진, [키워드] herpesvirus interferon mouse reactive oxygen species redox regulation STING [DOI] 10.7554/eLife.57837 PMC 바로가기 [Article Type] article
Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?Review Published on 2020-07-052022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, [키워드] ACE2 activate Activation aneurysms Aspirin binding bleeding cell membrane children Coagulopathy Combination contribute COVID-19 COVID-19 patient cytosolic disease disorder DNA down-regulated downstream drug Herpes virus Hypothesis IL-6R immunoglobulins Inflammasome inhibit inhibited inhibitor innate cell intravenous IVIG JAK/STAT pathways Kawasaki disease lung tissue males mice monocyte-macrophages NLRP3 occur over-expressed pathway procoagulant activity promote prothrombotic pyroptosis reduce reported risk SARS-CoV2 severe COVID-19 patient severe COVID-19 patients Signaling STING thrombosis thrombotic tissue Tissue Factor Treatment triggering upstream Vasculitis viruses [DOI] 10.1080/22221751.2020.1785336 PMC 바로가기 [Article Type] Review
Beyond Anti-viral Effects of Chloroquine/HydroxychloroquineImmunology Published on 2020-07-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 affected anti-inflammatory property anti-viral effect antigen processing Antiviral appear Arthritis Autoimmune diseases autophagy cellular activation Chloroquine country COVID-19 COVID-19 pandemic COVID-19 patients cytosolic decrease detrimental discrepancy Effect Efficacy explain highlight Host immune response Hydroxychloroquine in vitro Inflammation Inflammatory cytokine inflammatory process inhibit interfere interferon limit lysosomal nucleic acids Patient progression receptor remained Replication required RIG-I SARS virus SARS-CoV2 SARS-CoV2 infection secretion Signaling STING therapy TLR Toll-like receptor Treatment type I interferon virus [DOI] 10.3389/fimmu.2020.01409 PMC 바로가기 [Article Type] Immunology
Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected HepatocytesArticle Published on 2020-05-292023-06-02 Journal: Viruses [Category] B형 간염, [키워드] cGAS Hepatitis B virus (HBV) innate immune sensing Innate immunity interferon response STING [DOI] 10.3390/v12060592 PMC 바로가기 [Article Type] Article
Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses스트렙토코쿠스 뉴모니아의 포스포디에스터레이스 2의 독특한 역할: 사이클릭 디-AMP 분해 및 대식세포 반응Original Research Published on 2020-03-312024-07-31 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] cyclic di-AMP Innate immunity Interferon-β macrophages pneumococcus Pneumonia STING [DOI] 10.3389/fimmu.2020.00554 PMC 바로가기 [Article Type] Original Research
Duck TRIM32 Functions in IFN-β Signaling Against the Infection of H5N6 Highly Pathogenic Avian Influenza VirusOriginal Research Published on 2020-02-282023-05-31 Journal: Frontiers in Immunology [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza virus duck IFN-β STING TRIM32 [DOI] 10.3389/fimmu.2020.00377 PMC 바로가기 [Article Type] Original Research
Type I IFN expression is stimulated by cytosolic MtDNA released from pneumolysin-damaged mitochondria via the STING signaling pathway in macrophagesarticle Published on 2019-12-312024-09-01 Journal: The FEBS Journal [Category] 폐렴구균 감염증, [키워드] IFN-β mitochondrial damage mtDNA PLY STING [Article Type] article
Functional Characterization of Duck STING in IFN-β Induction and Anti-H9N2 Avian Influenza Viruses InfectionsOriginal Research Published on 2019-09-182023-05-31 Journal: Frontiers in Immunology [Category] Fulltext, 조류인플루엔자, [키워드] AIV antiviral immune response duck IFN-β STING [DOI] 10.3389/fimmu.2019.02224 PMC 바로가기 [Article Type] Original Research