Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaptionSARS-CoV-2 스파이크 단백질의 돌연변이 Y453F는 숙주 적응을 위해 밍크 ACE2 수용체와의 상호 작용을 향상시킵니다Research Article Published on 2021-11-082022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, [키워드] ACE2 ACE2 receptor Active surveillance adaptive addition Amino acid amino acid change Analysis binding circulation Cluster convalescent sera convalescent serum COVID-19 patient COVID-19 patients demonstrated develop domain employee ENhance Evolution exhibited functional Genetic variant Host human ACE2 human ACE2 receptor humans identify infected with SARS-CoV-2 initial Interaction less MONITOR Mutation Netherland Netherlands ortholog outbreak Outbreaks position Prevent RBD domain receptor reservoirs risk SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 RBD sequence similarity Spike protein steric Structural analysis suggested susceptible susceptible hosts the RBD the spike protein therapeutic strategy Transmission transmitted Vaccine development Viral viral RBD virus widespread Y453F zoonotic [DOI] 10.1371/journal.ppat.1010053 PMC 바로가기 [Article Type] Research Article
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants새로 출현한 돌연변이 변이체에 대한 보호 효능이 있는 강력한 SARS-CoV-2 중화 항체Article Published on 2021-11-022022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody authentic SARS-CoV-2 virus B.1.351 bind candidate Candidates COVID-19 COVID-19 pandemic cryo-EM E484K mutation Efficacy evidenced expressing hACE2 human ACE2 Immune escape in vitro in vivo mAbs mechanism monoclonal antibodies monoclonal antibody Mutation Neutralizing Neutralizing antibodies overlapping potent Prophylactic Prophylaxis Protective Protein RBD Receptor binding domain recognize reducing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 virus spike steric Structural analysis the RBD the SARS-CoV-2 transgenic mice treat unique variant virus virus infection viruses weight loss [DOI] 10.1038/s41467-021-26539-7 PMC 바로가기 [Article Type] Article
Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 virusesSARS-CoV-2 바이러스의 Delta 및 Delta Plus 변이체의 진화 분석Article Published on 2021-11-012022-09-11 Journal: Journal of autoimmunity [Category] SARS, 변종, [키워드] A222V acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alter Analysis antibodies Antibody binding AY.1 B.1.617.2 B.1.617.2.1 conducted coronavirus 2 correlated Delta Delta plus variant delta variant determine England FIVE followed by G142D India Interaction Japan K417N Migration Mutation ORF1a Phylogenetic analysis Prevalence prevalent profiles reached reported respiratory Sankey diagram SARS-CoV-2 SARS-CoV-2 genome sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus signature significantly more spike spread to Structural analysis the SARS-CoV-2 the United State The United States unique United States variant variants virus were used [DOI] 10.1016/j.jaut.2021.102715 PMC 바로가기 [Article Type] Article
Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617Microbiology Published on 2021-10-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome amino acid change analyzed B.1.617 B.1.617.2 binding ability Biological biological significance circulating coronavirus country COVID-19 pandemic Deletion Dynamics Follow-up Frequency genetic diversity Genome genomic variation Haplotype Haplotype network increasingly India indicated involved L452R lifted Lineage measure molecular evolution mutant Mutation N501Y nonstructural proteins P681R pandemic Positive selection predominant prevalent reported SARS-CoV-2 sequence sequenced Significance Single nucleotide polymorphism SNPs Spread Structural analysis structural proteins Substitution tertiary structure the S protein the vaccine tracing variant viral genome [DOI] 10.3389/fmicb.2021.750725 PMC 바로가기 [Article Type] Microbiology
Potential Antigenic Cross-reactivity Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue Viruses중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)와 뎅기열 바이러스 간의 잠재적 항원 교차 반응성Article Published on 2021-10-052022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed antibodies antibody Clinical data consequence Control control group coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity Dengue Dengue fever dengue virus diagnosed domain ELISA ELISA testing envelope protein enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes False-positive healthy individual identify IgA IgG IgG antibodies IgM Immunoglobulin Immunoglobulin G immunoglobulin M Implications in-silico include individual Infection Laboratory features lead Patient Patient care performed positive Potential Protein public health Rapid test respiratory S protein SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology serum sample serum samples severe acute respiratory syndrome Coronavirus similarities similarity Spike protein Structural analysis subject Support tested the S protein the spike protein West West Nile [DOI] 10.1093/cid/ciaa1207 PMC 바로가기 [Article Type] Article
Epitope Profiling Reveals the Critical Antigenic Determinants in SARS-CoV-2 RBD-Based AntigenImmunology Published on 2021-09-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] analyzed antibodies Antibody Response Antigen B-cell epitope binding caused characterized conserved COVID-19 COVID-19 pandemic cross-reactive antibody determinant diagnostic domain effort epitope facilitate globe humoral IFA immunization immunized immunodominant immunodominant epitope immunogenic in viral Infection information linear mapped mice monoclonal antibody neutralization activity Neutralizing antibodies peptide peptides Profiling Protein public health crisis RBD RBM receptor binding motif Result SARS-CoV SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S trimer SARS-CoV-2 spike SARS-CoV-2 strains SARS-CoV-2 vaccine sera Spike protein Structural analysis the antibody response the RBD [DOI] 10.3389/fimmu.2021.707977 PMC 바로가기 [Article Type] Immunology
A method for intuitively extracting macromolecular dynamics from structural disorderArticle Published on 2021-09-172022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] accounted Analysis approach conformations Cryo-electron microscopy cryo-EM structures disorder example Factors Hierarchical hypothese Implications information macromolecular molecular molecular mechanisms parameter Proteins Quantitative SARS-CoV-2 SARS-CoV-2 proteins STEAP4 Structural analysis structural biology Structure Structure determination structures temperature [DOI] 10.1038/s41467-021-25814-x PMC 바로가기 [Article Type] Article
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variantsSARS-COV-2 수용체 결합 도메인 항체 인식의 구조적 및 에너지 프로파일 링 및 순환 변이체의 영향Research Article Published on 2021-09-072022-09-10 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] affected Alpha Analysis antibody atomic Author B.1.1.7 B.1.617.2 binding binding domain circulating variant Clustering Community complex computational modeling Contact COVID-19 pandemic dataset Delta described determinant disrupt epitope epitope conservation evade feature group high resolution highlight identify immune response immune responses less molecular monoclonal antibodies monoclonal antibody Mutation mutations natural infection Neutralizing antibodies performed predicted Protective antibody protective antibody responses RBD Receptor binding domain Research residue residues SARS-CoV-2 pandemic SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus spike glycoprotein Spread Structural analysis Structure structures target the SARS-CoV-2 the SARS-CoV-2 virus therapeutic Unsupervised clustering Vaccine Vaccine design Vaccines variants Viral viral variant Viral variants was used [DOI] 10.1371/journal.pcbi.1009380 PMC 바로가기 [Article Type] Research Article
The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use인간 사용을 위한 DNA 유전자형 Aotus 원숭이에서 최초의 화학적으로 합성되고 면역원성이 높은 항-SARS-CoV-2 펩티드Immunology Published on 2021-09-032022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] analysed antibody antigenicity association Coverage COVID-19 DNA ELISA titre for inclusion highlight HLA alleles HLA-DRβ1*/Aona-DRβ host cell Human humans IFA immune protection immune response immunogenic immunogenic peptide immunological Infection long-lasting membrane MHC class MHCII MHCII-peptide-TCR complex Mild modified synthetic peptide Monkey neutralising antibody parental Patient peptide peptides Population PPIIL-propensity predicted producing Protein SARS-CoV-2 SARS-CoV-2 neutralising antibody SARS-CoV-2 spike selected serum sample severe SARS-CoV-2 Structural analysis suggested were used [DOI] 10.3389/fimmu.2021.724060 PMC 바로가기 [Article Type] Immunology
Energetic and structural basis for the differences in infectivity between the wild-type and mutant spike proteins of SARS-CoV-2 in the Mexican population멕시코 인구에서 SARS-CoV-2의 야생형 스파이크 단백질과 돌연변이 스파이크 단백질 간의 감염성 차이에 대한 에너지 및 구조적 기초Article Published on 2021-09-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] SARS, 변종, [키워드] ACE2 affinity Analysis approach binding binding affinity binding free energy causative agent conformational conformational flexibility contribute COVID-19 D614G death decrease explained free energy global public health increase in Lineage MD simulation MD simulations molecular molecular dynamics Molecular dynamics simulation Molecular mechanics mutant mutant spike protein pandemic pandemic of COVID-19 performed Protein protein-protein interface S-protein SARS-CoV-2 spike Spike protein Structural analysis surface area the binding affinity the spike protein third position variant virus wild-type X-ray crystallography [DOI] 10.1016/j.jmgm.2021.107970 PMC 바로가기 [Article Type] Article