Aspulvins A-H, Aspulvinone Analogues with SARS-CoV-2 M pro Inhibitory and Anti-inflammatory Activities from an Endophytic Cladosporium spAspulvins A-H, SARS-CoV-2 M pro 억제 및 항염증 활성을 갖는 Aspulvinone 유사체 내생성 Cladosporium sp에서Review Published on 2022-04-222022-09-11 Journal: Journal of natural products [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus analogue analogues Analysis anti-inflammatory activity candidate Candidates Casp caused Cladosporium cleavage Compound compounds conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cultures determine IL-1β Infection inflammatory reaction inflammatory reactions inhibit SARS-CoV-2 inhibiting inhibitory activity isolate Lactate lactate dehydrogenase LDH M pro maturation NLRP3 NLRP3 inflammasome occurred protease pyroptosis reduce SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Structure structures Treatment [DOI] 10.1021/acs.jnatprod.1c01003 PMC 바로가기 [Article Type] Review
Cocktail of REGN Antibodies Binds More Strongly to SARS-CoV-2 Than Its Components, but the Omicron Variant Reduces Its Neutralizing AbilityREGN 항체 칵테일은 성분보다 SARS-CoV-2에 더 강하게 결합하지만 오미크론 변이체는 중화 능력을 감소시킵니다Article Published on 2022-04-212022-09-11 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ability antibody antiviral antibodies antiviral antibody appear approach association bind binding calculated change coarse-grained simulation coarse-grained simulations cocktail complexes components computational method contribute COVID-19 infections Delta delta variant dissociation constants driven by effective Effectiveness electrostatic interaction electrostatic interactions Infection Interaction interactions K417N molecular molecular dynamics molecular mechanism molecular mechanisms Mutation neutralize Neutralizing activity omicron Omicron variant RBD Receptor-binding domain reduce REGN10933 REGN10987 SARS-CoV-2 SARS-CoV-2 spike protein shown Spike protein Structure structures the receptor-binding domain the SARS-CoV-2 Treatment treatment of COVID-19 understanding van der Waal van der Waals interactions variant virus [DOI] 10.1021/acs.jpcb.2c00708 PMC 바로가기 [Article Type] Article
Structural conservation among variants of the SARS-CoV-2 spike postfusion bundleSARS-CoV-2 스파이크 후 융합 번들의 변종 간의 구조적 보존Article Published on 2022-04-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter antiviral inhibitor antiviral inhibitors assembly change coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines cryo-EM cryogenic electron microscopy determine domain eight functional glycoprotein heptad repeat host cell HR1HR2 Interaction local effect membrane fusion Microscopy molecular monoclonal antibody mutant Mutation mutations Nostoc omicron Omicron variant postfusion related viruses reported resulting SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected severe acute respiratory syndrome Coronavirus similar studies similar study spike glycoprotein Structure structures target the SARS-CoV-2 therapy trimeric variant variants of SARS-CoV-2 Viral RNA viral spike wild-type [DOI] 10.1073/pnas.2119467119 PMC 바로가기 [Article Type] Article
Altered hypoxia inducible factor regulation in hereditary haemorrhagic telangiectasia Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] affecting Altered analysed BMP Brain characterized clinical phenotype consequence contribute decreased expression downregulated downregulation dysregulation Effect expression Factor Gene Expression growth HIF-1α HIF1a human disease hypoxia immune response indicate Inflammatory Inflammatory response interact Interaction liver lung malformation mechanism mRNA Mutation no correlation not affected pathway Patient patients protein level rare disease Regulation severity Shunt significantly Structure structures syndrome target gene telangiectasia TGF-β upstream vessel whole blood sample [DOI] 10.1038/s41598-022-09759-9 [Article Type] Research
Treatment of a full-thickness macular hole and retinal detachment secondary to toxoplasma chorioretinitis that developed shortly after COVID-19: A case reportResearch article Published on 2022-04-012022-10-05 Journal: Journal français d'ophtalmologie [Category] 치료법, [키워드] anatomical Antibiotic therapy approach Case report chorioretinitis Complication complications concerning COVID-19 demonstrated develop diagnosed full-thickness full-thickness macular hole functional Infection Inflammation Macular hole membrane novel coronavirus disease Ocular toxoplasmosis reduction in Retinal detachment serological severity structures surgical the patient Toxoplasma toxoplasmosis Treatment visual acuity vitreoretinal surgery vitreous [DOI] 10.1016/j.jfo.2021.12.004 [Article Type] Research article
Two years after lockdown: reviewing the effects of COVID-19 on health services and support for adolescents living with HIV in South Africa폐쇄 2년 후: 남아프리카 공화국에서 HIV에 감염된 청소년을 위한 의료 서비스 및 지원에 대한 COVID-19의 영향 검토Article Published on 2022-04-012022-09-11 Journal: Journal of the International AIDS Society [Category] 치료제, [키워드] Adolescent adolescents living with HIV affecting Antiretroviral therapy ART ART adherence barriers Care Child consequence COVID-19 Decline Effect greater Health health facilities Health Service Health services healthcare healthcare facility Healthcare system healthcare worker Healthcare workers HIV HIV disease HIV testing identify indirect effect limitation limited support maintain mental health conditions MONITOR National opportunistic infection opportunistic Infections pandemic populations Pregnancy progression Psychological public health reduced reducing Reflecting reproductive resource resource reallocation. resources retention risk Sex Side effects significantly South Africa Structure structures Support Surveillance susceptible therapeutic relationship Transmission Treatment unintended pregnancy with COVID-19 with HIV [DOI] 10.1002/jia2.25904 PMC 바로가기 [Article Type] Article
Coronavirus Genomes and Unique Mutations in Structural and Non-Structural Proteins in Pakistani SARS-CoV-2 Delta Variants during the Fourth Wave of the Pandemic팬데믹의 네 번째 물결 동안 파키스탄 SARS-CoV-2 델타 변이체의 구조 및 비구조 단백질의 코로나바이러스 게놈 및 고유 돌연변이Article Published on 2022-03-212022-09-11 Journal: Genes [Category] SARS, 변종, 치료기술, [키워드] Affect Analysis B.1.617.2 Belgium collected Continuous Delta delta variant Delta variants Efficacy effort Epidemiology Evolution exhibiting GenBank Genome genome sequence Genome sequences genomic genomic sequence GISAID global public health imperative management Molecular epidemiology Mutation mutations Next-generation sequencing non-structural protein Non-synonymous Non-synonymous mutation NSP Nsp12 Nsp3 nsp5 Numerous Pakistan Papain-like protease pathogenicity positive sample protease public health RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants sequenced Spike protein stability stabilizing effect structures the spike protein therapeutic Transmission unique Vaccine vaccine efficacy variant variants virus viruses Wave whole genome [DOI] 10.3390/genes13030552 PMC 바로가기 [Article Type] Article
Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in InflammationReview Published on 2022-03-032022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] acting Anti-inflammatory anti-inflammatory activity Bioactivity carried correlated COVID-19 DHA disease docosahexaenoic acid drug design drugs dysregulation Evidence fatty functional Inflammation lipid mediator maresins marine sources metabolite omega-3 organism pharmacological precursor protectins Regulatory resolvins resource role SPMs Structure structures synthetic synthetic approaches target Treatment unique [DOI] 10.3390/molecules27051677 PMC 바로가기 [Article Type] Review
Conformational variability of loops in the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질 루프의 구조적 가변성Article Published on 2022-03-012022-09-11 Journal: Proteins [Category] SARS, 변종, [키워드] Accuracy Analysis applied binding Characteristics Cluster cluster analysis conformation conformational conformational ensembles conformations COVID-19 decoy selection facilitate flexible identify involved loop loop modeling Protein Protein binding Protein Data Bank protein structure protein structure prediction Region SARS-CoV-2 spike sequence sequence variants. Spike protein structures targets the S protein the SARS-CoV-2 Variability variants viral infection while [DOI] 10.1002/prot.26266 PMC 바로가기 [Article Type] Article
Interactions of Co, Cu, and non-metal phthalocyanines with external structures of SARS-CoV-2 using docking and molecular dynamicsArticle Published on 2022-02-282022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] Adsorption antagonist approach approaches atomic candidate caused Characteristics characterized Cobalt Computational models Computational neuroscience Computational platforms and environments Contamination contribute copper COVID-19 pandemic deviation docking Dynamics envelope protein Gibbs free energy glycoprotein information inhibitor Interaction lethality rate Ligand macromolecules Masks molecular Molecular docking study molecular dynamics New coronavirus occur predict protease Proteases Protein analysis Protein function predictions provided residue SARS-CoV-2 Software solvent spike Structure structures Virtual drug screening virus were used [DOI] 10.1038/s41598-022-07396-w PMC 바로가기 [Article Type] Article