suppresse – Page 5 – Communicable Diseases Research

The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults

Research Article

Published on 2021-08-312022-10-29
Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19,

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

Research Article

Published on 2021-08-262022-10-29
Journal: PLoS Pathogens [Category] COVID-19, SARS,

[키워드] activating Activation added Anti-viral anti-viral activity antiviral drugs antiviral gene block blocked caused cells coronavirus COVID19 COVID19 patient cytokine decrease Defense demonstrated disseminate early infection early stage Effect evade expression Genome help Host IFN IFN-I IFN-I response IFN-I signaling IFN-Is IFNα IFNβ IFNγ immune system independent Infection inhibiting Innate immunity interferon ISGs mechanism mRNA levels Mutant SARS-CoV-2 nsp1 nsp5 NSP6 ORF6 ORF7b proportion Protein provide pSTAT1 reduced remained required responsible robust SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 infected cell SARS-COV-2 infection secretion Singapore Stat1 Support suppress suppresse suppressed Taiwan tested the SARS-CoV-2 therapeutic translation treat triggering Type type I Type III IFN variant viral infection virus with mild disease Δ382
[DOI] 10.1371/journal.ppat.1009800 PMC 바로가기 [Article Type] Research Article

A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses

Article

Published on 2021-08-182022-10-28
Journal: Viruses [Category] COVID-19, Fulltext, SARS, 조류인플루엔자,

[키워드] activity acute respiratory syndrome antiviral therapy caused clinical trials coronavirus Coronavirus replication demonstrated derivative drug candidate Efficiency examined frameshift frameshifting gene cluster identify in viral in vitro inhibit inhibitor inhibitors inhibitory effect interfere less MERS-CoV MERS-CoV-infected cells Middle East novel outbreak RdRP recent Repurposed drug respiratory syndrome coronavirus RNA RNA-dependent RNA polymerase RNAs SARS-CoV SARS-CoV-2 searched Shock shown small molecule suppresse therapeutic agent therapeutic efficacy translated translation viral propagation zoonotic coronaviruses
[DOI] 10.3390/v13081639 PMC 바로가기 [Article Type] Article

A model of the innate immune response to SARS-CoV-2 in the alveolar epithelium

Mathematics

Published on 2021-08-112022-10-28
Journal: Royal Society Open Science [Category] COVID-19,

SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

SARS-COV-2 N 단백질은 타고난 면역을 억제하기 위해 TRIM25- 매개 RIG-I 활성화를 표적으로합니다.

Article

Published on 2021-07-232022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료법,

[키워드] accessory proteins Activation Affect affecting antagonistic characterized clinical picture contributing to counteract COVID-19 Cytokines decrease demonstrated domain ENCODE exacerbated expressed feature host immune system IFN Infection Innate innate immune response Innate immunity Interaction involved Mask mechanism molecular mechanism molecular mechanisms N protein novel SARS-CoV-2 virus occurred Pathways Pattern recognition pattern recognition receptor pro-inflammatory cytokine pro-inflammatory cytokines Protein PRR Recognition reported RIG-I RIG-I activation SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 virus secretion signaling pathways suppresse target the N protein the SARS-CoV-2 TRIM25 Viral viral pathogenesis
[DOI] 10.3390/v13081439 PMC 바로가기 [Article Type] Article

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Article

Published on 2021-07-132022-10-04
Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제,

[키워드] antiviral drug antiviral therapeutics approach B.1.1.7 cellular circumvent CRISPR CRISPR-Cas systems D614G degrade demonstrated described dominant variant effector Efficiency genomic highlight host immunity impair Interaction mammalian cell mammalian cells molecular Mutagenesis mutant mutated pathogenic viruses Prevent Region replication-competent SARS-CoV-2 Resilience RNA RNA transcript RNAi RNAi therapy SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 replication SARS-CoV-2 strain SARSCoV-2 single-nucleotide specificity spike subgenomic RNAs suppress suppresse Synthetic biology the Spike Tolerance transcript variant variants of concern viral escape viral replication
[DOI] 10.1038/s41467-021-24577-9 PMC 바로가기 [Article Type] Article

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

Research

Published on 2021-07-082022-10-05
Journal: Nature cell biology [Category] SARS, 변종, 치료제,

Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling

Oncology

Published on 2021-07-022022-10-31
Journal: Frontiers in Oncology [Category] COVID-19,

Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform

SARS-COV-2 감염에서 L-DOPA 데카르 복실 라제 발현의 변경 및 인터페론-유도 성 ACE2 이소 형과의 연관성

Research Article

Published on 2021-06-292022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술,

[키워드] ACE2 ACE2 expression alteration analyzed antiviral response association cell death cell population co-expressed correlated correlation COVID-19 COVID-19 patient COVID-19 patients cultured virus DDC Effect elevated ENCODE enrichment epithelial cells EPO evaluated expression favor Gene Expression Host host gene expression hours post-infection hypoxia in viral individual individuals infected cells infected individuals infections Influenza influenza-infected patients interferon interferon-stimulated gene isoform L-DOPA mild symptoms mRNA level mRNA levels nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples negatively affected non-infected Patient qPCR quantified receptor Regulation RT-qPCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 virus SARS-CoV-2-infected cells SARS-CoV-2-infected individuals significantly statistically significant subjects suppresse the SARS-CoV-2 tissue VeroE6 cells Viral viral infection viral infections Viral load virus while whole blood sample
[DOI] 10.1371/journal.pone.0253458 PMC 바로가기 [Article Type] Research Article

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes

420

Published on 2021-06-292022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS,

[키워드] activate activated acute respiratory syndrome affected alarmin antibody Blood Cell clinical conditions coronavirus COVID-19 COVID-19 infection epithelial cells expression Factors favor function HIF-1α HIF-1α HMGB1 human monocytes hypoxia hypoxic hypoxic conditions IFN implication induce Infection Inflammatory cytokine interferon interferon regulatory factor investigated IRF3 IRF5 microenvironment monocyte Monocyte activation Monocytes Necrosis normoxic nuclear oxygen pathogenesis of COVID-19 pathophysiology produced Proinflammatory cytokine proinflammatory cytokines Regulatory released secretion Severe COVID-19 Infection shown Significance stressed cells suppresse tissue transcriptional transcriptional repressor Type I IFN type I interferon
[DOI] 10.1073/pnas.2106017118 PMC 바로가기 [Article Type] 420