surface receptor – Page 5 – Communicable Diseases Research

Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity

Review

Published on 2020-10-222022-10-31
Journal: Human Genomics [Category] COVID-19, MERS, SARS,

Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans

Cryptococcus neoformans에서 가져온 쿼럼 센싱 펩타이드에 의해 제어되는 전사 인자의 게놈 연관성을 조정합니다.

Research Article

Published on 2020-09-212022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acting Affect association binding Cell Cell density cell surface receptor cell wall change chromatin immunoprecipitation Control control cell Coordinate Cryptococcus Cryptococcus neoforman Cryptococcus neoformans Deletion eukaryotic expression form function functions fungal fungal pathogens Gene Expression Genes Genetic genomic genomic studies genomic study human body Hypothesis identify Impact infect Macrophage macrophages mating mechanism Meningitis microbe modulate modulating pathogen pathogenic Pathogens peptide predicted promote promoters proximal quorum regulated required reveal secreted surface receptor target transcription factor transcription factors virulence whole-genome
[DOI] 10.1371/journal.pgen.1008744 PMC 바로가기 [Article Type] Research Article

Acute RNA Viral Encephalomyelitis and the Role of Antibodies in the Central Nervous System

Review

Published on 2020-09-052022-10-28
Journal: Viruses [Category] COVID-19,

Nrf2 Activator PB125 ® as a Potential Therapeutic Agent against COVID-19

Article

Published on 2020-06-122022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

[키워드] “cytokine storm” HDAC5 ACE2 activate Activation activator Adhesion Molecule affecting age agent ALI Antiviral assays Cell cellular chronic inflammation coronavirus COVID-19 CXCL10 cytokine Cytokine storm Cytokines Decline decrease Diseases downregulate downregulation E-selectin endothelial cells Evidence examined expression gene expression level GeneChip Genes genes encoding HepG2 cells host cells ICAM-1 IL-6 Immunity include Inflammation intensity involved LIF mechanism Microarray mRNA expression NFE2L2 Nrf2 oxidative Potential regulate Replication RNA-Seq SARS-CoV-2 SARS-CoV-2 entry significantly surface receptor susceptibility susceptible the spike protein TMPRSS2 TNF-α transcription factor type 2 diabetes VCAM-1 viral infections
[DOI] 10.3390/antiox9060518 PMC 바로가기 [Article Type] Article

Cross‐species transmission of the newly identified coronavirus 2019‐nCoV

Research Article

Published on 2020-02-192022-11-01
Journal: Journal of medical virology [Category] COVID-19, SARS, 조류인플루엔자,

Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4

Article

Published on 2018-06-272022-10-29
Journal: Scientific Reports [Category] Coronavirus,

[키워드] accompanied addition analyzed Cell ciliary Coronavirus infections demonstrated Dipeptidyl peptidase 4 disease DPP4 eight epithelial cell expressed expressing expression level Health highlight histology immunofluorescence immunohistochemistry immunolabeling Infection information investigated lack lymphocyte Macrophage macrophages manifestation MERS MERS-CoV MERS-CoV infection Microscopy Middle East Monocytes nasal turbinate outcome Pathogenesis patients PBS positive cells post infection promote receiving recent Respiratory disease source of infection surface receptor syndrome T cells tissue vaccination viral cell virus virus entry
[DOI] 10.1038/s41598-018-28109-2 PMC 바로가기 [Article Type] Article

A structural view of coronavirus–receptor interactions

Article

Published on 2014-10-142022-11-01
Journal: Virus research [Category] Coronavirus,

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다

Research Article

Published on 2013-04-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer
[DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article

A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria

A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article