Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathologyArticle Published on 2020-11-012023-07-12 Journal: EBioMedicine [Category] SARS, [키워드] COVID-19 Endothelial dysfunction Post-mortem analysis SARS-CoV-2 Spike protein Syncytia [DOI] 10.1016/j.ebiom.2020.103104 PMC 바로가기
A Single V672F Substitution in the Spike Protein of Field-Isolated PEDV Promotes Cell–Cell Fusion and Replication in VeroE6 CellsArticle Published on 2019-03-202022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid amino acid residue aminopeptidase N Analysis cell lines cell–cell fusion cells characterized chimeric chimeric proteins Critical demonstrated Efficiency Enterocyte epidemic diarrhea expressing fusion host cells Huh-7 cells identify induce infect Mutation Neonatal passages PEDV RBD receptor Receptor binding domain receptor preference replaced replicate responsible S protein S proteins S1/S2 cleavage site single mutation spike Substitution Syncytia syncytium syncytium formation the RBD the Spike the spike protein triggered variant VeroE6 cell virus while [DOI] 10.3390/v11030282 PMC 바로가기 [Article Type] Article
Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia FormationResearch Article Published on 2013-10-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cell activate Affect antibody bats Betacoronavirus blocked cathepsin L cathepsin L-dependent Cell cell type Cl cleave cleaved co-expressed coronavirus coronavirus spike glycoprotein determined elicit endosome Eptesicus experiment Express Extracellular fluids Formation function glycoprotein host cell host protease host range Human immunoblot inhibitor lentivirus maturation membrane fusion MERS MERS-CoV MERS-CoV S protein MHV Middle East murine Neutral Neutralizing antibodies New World non-infectious plasma membrane polyclonal produced producing pseudotype pseudovirion pseudovirus entry reagent receptor released Research respiratory role S protein S2 domain serine protease Spike protein Syncytia syncytia formation the S protein the Spike tissue Treatment triggered trypsin variety VERO E6 cells viral spike virus virus entry [DOI] 10.1371/journal.pone.0076469 PMC 바로가기 [Article Type] Research Article