the S1 subunit – Page 5 – Communicable Diseases Research

Identification of potential inhibitors of SARS-CoV-2 S protein–ACE2 interaction by in silico drug repurposing

Silico 약물 용도로 SARS-COV-2 S 단백질 -ACE2 상호 작용의 잠재적 억제제 확인

Research Article

Published on 2021-11-112022-08-31
Journal: F1000Research [Category] MERS, SARS, 신약개발,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approved Asthma Atypical pneumonia binding binding site cause chronic obstructive chronic obstructive pulmonary disease Compound coronavirus COVID-19 COVID-19 disease criteria death docking score drug Drug repurposing drugs targeting evaluate FDA fexofenadine formoterol Frequency generate host cell identification in silico in vitro in vivo Infection inhibitor inhibitors inhibitors of SARS-CoV-2 Interaction interaction site internalization ipratropium molecular docking Mortality New coronavirus obstructive pulmonary disease PDB PDB ID performed Pneumonia protein S pulmonary disease RBD receptor Receptor binding domain receptor site Replication reported Research residue respiratory respiratory infection S protein S1 subunit SARS-CoV-2 SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specialist the S1 subunit therapy treat Treatment virus were used Wuhan Wuhan, China
[DOI] 10.12688/f1000research.52168.2 PMC 바로가기 [Article Type] Research Article

Recombinant Protein Expression and Purification of N, S1, and RBD of SARS-CoV-2 from Mammalian Cells and Their Potential Applications

Article

Published on 2021-09-302022-10-31
Journal: Diagnostics [Category] COVID-19,

[키워드] acute respiratory syndrome Antigen application cells cleaved coronavirus coronavirus disease country COVID-19 demonstrated diagnostic diagnostics enzyme-linked immunosorbent assay expression human serum identify immunogenic induce infected with COVID-19 mammalian N protein Neutralizing antibodies nucleocapsid pandemic Patient plasmids Potential Protein purified RBD RBD of SARS-CoV-2 RBD proteins reached Receptor binding domain recombinant S1 and S2 SARS-CoV-2 serological Serological assay severe acute respiratory syndrome coronavirus 2 Spike protein structural protein the receptor-binding domain the S1 subunit the SARS-CoV-2 Viral antigen was used
[DOI] 10.3390/diagnostics11101808 PMC 바로가기 [Article Type] Article

A non-RBM targeted RBD specific antibody neutralizes SARS-CoV-2 inducing S1 shedding

비-RBM 표적화된 RBD 특이적 항체는 S1 발산을 유도하는 SARS-CoV-2를 중화합니다

Article

Published on 2021-09-242022-09-12
Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단,

Next-Generation Sequencing Reveals Four Novel Viruses Associated with Calf Diarrhea

Article

Published on 2021-09-232022-10-28
Journal: Viruses [Category] Coronavirus,

Evaluation of Inhibitory Activity In Silico of In-House Thiomorpholine Compounds between the ACE2 Receptor and S1 Subunit of SARS-CoV-2 Spike

Article

Published on 2021-09-172022-10-28
Journal: Pathogens [Category] COVID-19,

Inactivation Activities of Ozonated Water, Slightly Acidic Electrolyzed Water and Ethanol against SARS-CoV-2

Communication

Published on 2021-09-082022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Neutralizing antibodies for the prevention and treatment of COVID-19

코로나19 예방 및 치료를 위한 중화항체

Review

Published on 2021-09-082022-09-11
Journal: Cellular and Molecular Immunology [Category] SARS, 변종, 비임상, 신약개발, 임상, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin-converting enzyme 2 antibody binding binding affinity cellular receptor coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 effective Efficiency focus followed by host cell Immunotherapy IMPROVE infection process information initiate membrane fusion monoclonal antibodies N-terminal domain NAb NAbs neutralization Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody Protein provide provided RBD Receptor-binding domain respiratory S protein S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 S protein SARS-CoV-2 strains SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein the receptor-binding domain the S protein the S1 subunit the SARS-CoV-2 therapeutic target Treatment treatment of COVID-19 Viral viral infection viral spike virus entry
[DOI] 10.1038/s41423-021-00752-2 PMC 바로가기 [Article Type] Review

Early antibody response in health-care professionals after two doses of SARS-CoV-2 mRNA vaccine (BNT162b2)

SARS-CoV-2 mRNA 백신(BNT162b2) 2회 접종 후 의료 전문가의 조기 항체 반응

Multicenter Study

Published on 2021-09-012022-09-11
Journal: Clinical microbiology and infection : the official [Category] SARS, 임상, 진단, 치료법,

[키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-spike antibodies anti-spike antibody antibody Antibody Response Antibody titre antibody titres baseline Belgium blood sample Blood samples BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine clinical trial collected conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine disease dose dose regimen hcp health-care Humoral response immune response individual individuals infected individual infected individuals lead mRNA vaccine multicentre nucleocapsid of BNT162b2 optimum dose professional reached Receptor binding domain respiratory S1 subunit SARS-CoV-2 SARS-CoV-2 nucleocapsid second dose seronegative severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly higher single dose Spike protein Support the S1 subunit the SARS-CoV-2 the spike protein titre two-dose regimen uninfected Vaccine Volunteer were excluded were measured
[DOI] 10.1016/j.cmi.2021.05.004 PMC 바로가기 [Article Type] Multicenter Study

The structural basis of accelerated host cell entry by SARS-CoV-2†

SARS-CoV-2에 의한 가속화된 숙주 세포 진입의 구조적 기초†

Article

Published on 2021-09-012022-09-11
Journal: The Febs Journal [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] accelerate accelerated ACE-2 ACE2-RBD acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme Antiviral strategies antiviral strategy base C-terminal domain causative agent cell entry cellular entry cleavage site conserved Contact contagious contribute coronavirus Coronavirus disease 2019 COVID-19 disease domain effective entry receptor enzyme epithelial epithelium exhibit explain faster Features flat furin furin protease HCoVs high-affinity binding host cell human coronavirus hypothese Interaction leads Mutation N-terminal domain notable NTD other proteases pandemic pandemic coronavirus Proteases Protein protein-protein interaction RBD receptor Receptor-binding domain respiratory respiratory epithelia S protein S1 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sialic acid sialic acid-binding domain. Spike protein subunit the receptor-binding domain the S protein the S1 subunit the spike protein Tight binding turn Viral viral RBD viral S viral spike
[DOI] 10.1111/febs.15651 PMC 바로가기 [Article Type] Article

A glycosaminoglycan microarray identifies the binding of SARS‐CoV‐2 spike protein to chondroitin sulfate E

Research Letter

Published on 2021-08-172022-10-31
Journal: Febs Letters [Category] COVID-19,