Coronavirus Host Genetics South Africa (COHG-SA) database-a variant database for gene regions associated with SARS-CoV-2 outcomes코로나바이러스 숙주 유전학 남아프리카(COHG-SA) 데이터베이스-SARS-CoV-2 결과와 관련된 유전자 영역에 대한 변이 데이터베이스Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Analysis article cause clinical clinical phenotypes COVID-19 curated database disease Epidemiology Factor gene region Genetic Genetic epidemiology global public health heterogeneous Host outcome phenotype provide Python Research response to therapy responsible SARS-CoV-2 SARS-CoV-2 virus South Africa Symptom the disease therapy These data variant with COVID-19 [DOI] 10.1038/s41431-022-01089-8 PMC 바로가기 [Article Type] Review
T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patientsResearch article Published on 2022-08-012022-10-05 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Admission Analysis B cell CD4+ T cell circulating Course COVID-19 creatinine Critical Critical disease decrease disease elevated higher risk Hospitalized hospitalized COVID-19 patient identify IL-6 immune response increased risk Infection marker men no significant difference Older Patient patients hospitalized percentage plasma predict progressed progression Result risk SARS CoV2 subset T cell T-cell Th17 cell Th17 cells therapy These data Tocilizumab two group women worsening [DOI] 10.1016/j.ejim.2022.06.001 [Article Type] Research article
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySARS-CoV-2 Omicron은 세포 진입 경로가 변경된 면역 탈출 변종입니다.Article Published on 2022-08-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Amino acid antigenicity B.1.1.529 BNT162b2 booster vaccination Cell cell entry Cell fusion ChAdOx1 changes in cornerstone COVID-19 described determined by Effectiveness endosomal entry endosomal entry pathway Immune escape Impaired in vitro increasingly individual induce mapped mRNA mRNA-1273 Mutation neutralization omicron Omicron variant Omicron variants pathogenicity pathway phenotype public health Receptor-binding domain reduction in Region replicative restored S2 domain SARS-CoV-2 sera Spike protein Spread Syncytia the receptor-binding domain the spike protein These data TMPRSS2 transmissible variant underlie Vaccine variant VoC VOCs was determined [DOI] 10.1038/s41564-022-01143-7 PMC 바로가기 [Article Type] Article
Upregulation of PD-1 Expression and High sPD-L1 Levels Associated with COVID-19 SeverityCOVID-19 심각성과 관련된 PD-1 발현 및 높은 sPD-L1 수치의 상향 조절Article Published on 2022-08-012022-09-11 Journal: Journal of Immunology Research [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] (PD-1 addition association Biomarker CD14 CD14+ monocyte CD14+ monocytes CD19 CD19+ cellular COVID-19 COVID-19 patients death Depletion evaluated Exhaustion expression Frequency increase in Infection inhibiting inhibitor lead Level lymphocyte Lymphocytes mechanism monocyte Monocytes Patient PD-1 Protein SARS-COV-2 infection SARS-CoV-2-infected patients severity TCD4 TCD8 the disease therapeutic target These cells These data with COVID-19 [DOI] 10.1155/2022/9764002 PMC 바로가기 [Article Type] Article
Expression profiles of respiratory V-ATPase and calprotectin in SARS-CoV-2 infection Research Published on 2022-08-012022-10-05 Journal: Cell Death Discovery [Category] 진단, 치료법, [키워드] A549 A549 cells activate activated acute respiratory syndrome approach Bronchoalveolar lavage fluid calprotectin caused cellular cleavage coronavirus Coronavirus disease 2019 COVID-19 Effect experiment expression flow cytometry fluorescent inflammatory cell Inflammatory response information International lung tissue microenvironment NHBE pandemic pathogenesis of SARS-CoV-2 pH value plasmid transfection polymerase chain profile Protein proteomics provided public health emergency respiratory epithelium S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike Sequencing Single-cell RNA sequencing suggested These data V-ATPase western blot [DOI] 10.1038/s41420-022-01158-3 [Article Type] Research
Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipientsSARS-CoV-2에 감염된 개인 및 백신 수혜자의 자연 살해 세포 매개 ADCCArticle Published on 2022-08-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] adaptive immune system ADCC ADCC activity anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines antibodies antibody antibody-dependent cellular cytotoxicity BNT162b2 BNT162b2 vaccine caused CD107a cells characterized collected correlated COVID-19 COVID-19 pandemic cross-reactive cross-reactive antibodies cross-reactive antibody degranulation Endemic expected expression focus global pandemic identify immune response immune responses individual infected individuals Innate Innate immunity killing less natural NK cell NK cells nucleocapsid Protein recipient Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2-infected individual second vaccination serum sample serum samples significantly significantly higher These data Trigger Vaccine while [DOI] 10.1002/eji.202149470 PMC 바로가기 [Article Type] Article
Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections1차 SARS-CoV-2 Omicron BA.1 및 BA.2 감염 후 다른 중화 프로필Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses B.1.1.529 B.1.617.2 breakthrough infections contribute controls coronavirus cross-neutralization cross-neutralizing Delta detectable ENhance Humoral immunity Immune escape individual individuals infected individuals Infection lineages Live virus mRNA mRNA vaccination multiple exposures mutated naïve neutralization neutralization test neutralization tests Neutralizing antibodies neutralizing antibody omicron Omicron sub-lineages Omicron variants other variants pre-immune Primary infection profile reduced respiratory SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 variant SARS-CoV-2 variant of concern SARS-CoV-2 variants serum Serum Neutralization serum sample serum samples severe acute respiratory syndrome Coronavirus specific neutralizing antibodies Spike protein Strains tested These data vaccinated individual vaccinated individuals Vaccination strategies Vaccination strategy Vaccinations variant variants wildtype [DOI] 10.3389/fimmu.2022.946318 PMC 바로가기 [Article Type] Article
Network approaches for modeling the effect of drugs and diseases약물 및 질병의 영향 모델링을 위한 네트워크 접근 방식Review Published on 2022-07-182022-09-11 Journal: Briefings in Bioinformatics [Category] COVID19(2023년), SARS, 신약개발, [키워드] adverse effects Algorithm approach biological networks biological response Chronic diseases Compound computational method Computational methods COVID-19 disease disease modeling Diseases drug drug combination drug combinations drug target drug treatments drug’s MOA drugs explain FDA-approved drug generate IMPROVE in silico induce mechanism mechanism of action network network analysis omics technologies Perturbation perturbations SARS-COV-2 infection SARS-CoV-2 infections Stage study drug Support targets therapeutic effect These data to define Treatment [DOI] 10.1093/bib/bbac229 PMC 바로가기 [Article Type] Review
The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD) recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while [DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article
Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19혈소판 활성화 및 부분 탈감작은 중증 COVID-19 환자의 바이러스 이종과 관련이 있습니다Article Published on 2022-07-122022-09-11 Journal: Blood advances [Category] COVID19(2023년), SARS, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Alter assays autophagy Bacterial sepsis changes in Combination Complication coronavirus Critically ill critically ill patients Cytokines decrease develop exhibited flow cytometry fraction Gene Expression GPVI healthy healthy donor healthy donors immunofluorescence indicated infected patient infected patients intensive care intensive care unit interactions intracellular vesicle investigated labeling leukocyte Localization lung marker mass spectrometry Microscopy Nucleocapsid proteins parameter Patient patients with COVID-19 plasma Platelet platelet activation platelet aggregation platelet-rich thrombi Platelets Proinflammatory cytokine proinflammatory cytokines prospective cohort Protein reduction SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles secretion selective Sepsis severe acute respiratory syndrome Coronavirus severe COVID-19 shown spike Stimulation Structure Tandem mass spectrometry These data thrombi thrombocytopenia transmission electron microscopy Xenophagy [DOI] 10.1182/bloodadvances.2022007143 PMC 바로가기 [Article Type] Article