A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8 across populationsArticle Published on 2020-11-012023-07-12 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, [키워드] ACE2 COVID-19 Genetic variant SARS-CoV-2 TLRs TMPRSS2 [DOI] 10.1016/j.meegid.2020.104507 PMC 바로가기
Design of novel multiepitope constructs-based peptide vaccine against the structural S, N and M proteins of human COVID-19 using immunoinformatics analysis면역정보학 분석을 이용한 인간 코로나19의 구조적 S, N, M 단백질에 대한 새로운 다중 에피토프 구조 기반 펩타이드 백신 설계Research Article Published on 2020-10-152022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] 3D structure acute respiratory syndrome adopted allergen Analysis analyzed approach B-cell B-cell epitope B-cell epitopes BepiPred Betacoronavirus binding calculated candidate Candidates causative agent cellular immune responses center China CDC Chinese clade cleavage contribute Control Coronaviridae Coverage COVID-19 CTL CTL epitope demonstrated develop disease control domain Efficiency elicit Ellipro epitope Epitopes GalexyPepDock highest HTL HTL epitopes humoral Hypothesis I-TASSER identify IEDB immune responses immunodominant immunoinformatics in silico in vivo Interaction linear MHC multiepitope vaccine N and M NCBI database NetCTL NetMHCpan novel Betacoronavirus peptide predicted proteasomal Protein RBD Receptor-binding domain regions reported respiratory S protein S, N and M proteins SARS-CoV-2 SARS-CoV-2 peptide vaccine SARS-CoV-2 susceptibility sequence Severe acute respiratory syndrome strong interactions Tap transport/proteasomal cleavage These data TLR TLRs TLRs 2, 3 and 4 Transport Vaccination strategies Vaccine virus was obtained [DOI] 10.1371/journal.pone.0240577 PMC 바로가기 [Article Type] Research Article
ssRNA Virus and Host Lipid Rearrangements: Is There a Role for Lipid Droplets in SARS-CoV-2 Infection?Molecular Biosciences Published on 2020-10-082022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome cellular organelle contagiousness coronavirus Coronavirus infection COVID-19 develop droplet effective therapy effort function highlight host–virus interaction in viral infections infective investigated knowledge LDs Lipid lipid droplet lipid droplets lipid homeostasis lipids molecular NF-κB pathway Patient PPAR profiles RNA viruses role Safe SARS-CoV-2 SARS-COV-2 infection Scientific community ssRNA ssRNA virus target TLRs Vaccine World Health Organization [DOI] 10.3389/fmolb.2020.578964 PMC 바로가기 [Article Type] Molecular Biosciences
A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling ApproachArticle Published on 2020-09-182022-10-28 Journal: Biology [Category] COVID-19, [키워드] accelerate Adaptive immune response adjuvant Analysis approved B-cell candidate cause caused checked China Comprehensive coronavirus COVID-19 demonstrated development Efficacy Escherichia coli expression globe Helicase help immunization in silico In silico cloning include infections initial Interaction lack linkers molecular molecular dynamics Molecular dynamics simulation molecular interaction Molecular modeling multiepitope vaccine multiple epitope non-structural protein novel Novel coronavirus outbreak pandemic Pathogens peptide polymerase Prophylactic protease protective immunity Repurposed drugs Research SARS-CoV-2 SARS-CoV-2 protein severe respiratory infection simple solution Spike protein Spread stability T-cell epitope three-dimensional structure TLRs Toll-like receptor Treatment triggering urgency Vaccine vaccine construct Vaccine design Vaccine development vaccine production Vaccines virus was used World Health Organization [DOI] 10.3390/biology9090296 PMC 바로가기 [Article Type] Article
Pattern Recognition Receptors: Significance of Expression in the LiverReview Published on 2020-09-172023-05-23 Journal: Archivum immunologiae et therapiae experimentalis [Category] B형 간염, Fulltext, [키워드] hepatic fibrosis Hepatitis Hepatocarcinogenesis liver PRRs TLRs [DOI] 10.1007/s00005-020-00595-1 PMC 바로가기 [Article Type] Review
4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor4,4′-다이아미노디페닐 설폰(DDS) 염증소체 경쟁자로서Article Published on 2020-08-192022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, 한센병, [키워드] 4,4′-diaminodiphenyl sulfone (dapsone) Activation AD Alter Alzheimer’s disease Alzheimer’s disease Antibiotics binding caspase-1 cause cleaved Cognitive impairment Combination DDS demonstrated diagnosed Diseases effective Effects Factor Fever fibrosis genetic polymorphisms Hansen’s disease human disease immune response implicated Inflammasome inflammasomes intracellular domain involved Korean lepromatous leprosy (also known as Hansen’s disease) leprosy ligands LL Lung inflammation MADDS mechanism microbial Mild molecular monoacetyldapsone MPO Mutation myeloperoxidase NACHT, LRR and PYD domains-containing protein 3 NLRP3 NLRP3 inflammasome Parkinson’s disease Patient protein 3 receptor Regulation reported responsible S protein SARS-CoV SARS-CoV-2 Sulfone susceptibility tested TLR TLR2 TLRs Toll-like receptor treated Treatment type 2 diabetes variety viruses zoonotic [DOI] 10.3390/ijms21175953 PMC 바로가기 [Article Type] Article
Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins병원체와 바이러스 효과 단백질에 의한 세포외 ISG15 신호 조절Article Published on 2020-06-162024-08-19 Journal: Cell Reports [Category] 살모넬라증, [키워드] ERVE Nairovirus vOTU foot and mouth disease virus Lbpro influenza B NS1 interferon-α/β interferon-γ ISG15 LFA-1 SARS-CoV-2/COVID-19 PLpro TLRs [DOI] 10.1016/j.celrep.2020.107772 PMC 바로가기 [Article Type] Article
Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptorResearch Article Published on 2020-06-122022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] adopted Analysis Antiviral applied binding energy COVID-19 determine enrichment functional protein GO and KEGG enrichment analysis Host Inflammatory inhibitor Interaction material metabolic process metabolism molecular docking MPro plants protease Protein rutin SARS-coronavirus SARS-CoV-2 main protease selected target therapeutic TLR TLR2 TLR6 TLR7 TLRs Toll-like receptor Toll-like receptors traditional antiviral medicinal plants [DOI] 10.2217/fvl-2020-0099 PMC 바로가기 [Article Type] Research Article
Identification and analysis of long non-coding RNAs that are involved in inflammatory process in response to transmissible gastroenteritis virus infectionResearch Article Published on 2019-11-042022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] acting Acute inflammation Analysis binding biological process Cell cell line differentially expressed element epithelial expression of gene gastroenteritis Genes identification Infection Inflammation inflammation response inflammatory process Inflammatory response intestinal intestinal epithelial cell involved leukemia lncRNA lncRNA binding proteins lncRNAs Long long non-coding RNA Messenger RNA microRNA miRNA miRNAs mRNAs Necrosis Next-generation sequencing NGS NLRs NOD-like receptor noncoding RNA p65 Pathways Phosphorylation PML profile Protein Proteins reduction Result RIG-I-like receptor RLRs TGEV TLRs TNF Toll-like receptor transcription factor transmissible gastroenteritis virus virus infection was used [DOI] 10.1186/s12864-019-6156-5 PMC 바로가기 [Article Type] Research Article
Human NK Cells and Herpesviruses: Mechanisms of Recognition, Response and Adaptationarticle Published on 2019-10-042024-09-02 Journal: Frontiers in Microbiology [Category] 대상포진, [키워드] activating receptors herpesvirus Memory responses NK cells TLRs viral reactivation [DOI] 10.3389/fmicb.2019.02297 PMC 바로가기 [Article Type] article