Animal Models for COVID-19: More to the Picture Than ACE2, Rodents, Ferrets, and Non-human Primates. A Case for Porcine Respiratory Coronavirus and the Obese Ossabaw PigMicrobiology Published on 2020-09-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 ACE2 protein angiotensin-converting enzyme 2 animal animal model bind binding cardiovascular disease caused Comorbidity COVID COVID-19 COVID-19 pandemic COVID-19 patient Critically ill determine diabetes diagnostics disease Express healthy hospitals host cell receptor Infection infection with SARS-CoV-2 investigated majority mechanism metabolic syndrome Mild Model MOST Non-human non-human primates obese obesity occur occurred Ossabaw pig outcome pig primates Research respiratory Respiratory Coronavirus rodents SARS-CoV-2 severe COVID-19 Spike protein susceptible syndrome transgenic Vaccines viral spike protein virus [DOI] 10.3389/fmicb.2020.573756 PMC 바로가기 [Article Type] Microbiology
Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeuticsArticle Published on 2020-09-082022-11-01 Journal: International immunopharmacology [Category] COVID-19, SARS, [키워드] “cytokine storm” 2019-nCoV Abstract ACE2 affected affecting Animal host Antiviral antiviral immune response approval Asymptomatic bat changed China Chinese horseshoe bat Chinese Horseshoe bats clinical clinical symptom coronavirus CoV COVID-19 COVID-19 convalescent patient COVID-19 patients Cytokines develop Drug discovery drugs Emerging infectious disease Evolution example expressing Factor FIVE generate hACE2 healthy Host host cell Host immune response host’s immune response Human humans immune response Immune status immune system Immunity immunomodulation immunomodulator immunomodulatory infecting Infection Measures mice Mild moderate pandemic Patient phenotype Prophylaxis receptor Replication SARS-CoV2 SARS-CoV2 infection SARSr-CoV scientist Section severe COVID-19 Severe infection severity subsequent susceptibility symptomatic symptoms of COVID-19 targeting transfer transgenic Treatment understanding Vaccine Vaccines viral disease viral infection virus Wuhan zoonotic [DOI] 10.1016/j.intimp.2020.106980 PMC 바로가기 [Article Type] Article
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19Research Published on 2020-09-042022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression aggregates aggregation bind binding blood stream cardiovascular complications CD62P changes in Coagulation factors coagulation parameter condition correlated COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill patient critically ill patients decrease demonstrated develop diagnosed with COVID-19 downstream ENhance evaluated Evidence Ex vivo expressed expression facilitate flow cytometry functional hACE2 healthy volunteers host cell receptor human Ace2 protein hyperactivity immunofluorescence in vitro in vivo inflammatory factors Inflammatory response inhibit SARS-CoV-2 investigated MAPK mice monoclonal antibody MPV Non-COVID-19 PAC-1 pathogenesis of COVID-19 pathway Platelet platelet activation Platelets priming pro-thrombotic Protein provided recombinant responsible Result risk RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virus secretion serine protease spike stimulated thrombosis thrombotic event thrombus formation TMPRSS2 transfused transgenic transgenic mice Volume wild-type [DOI] 10.1186/s13045-020-00954-7 PMC 바로가기 [Article Type] Research
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosisResearch paper Published on 2020-08-302022-11-01 Journal: EBioMedicine [Category] Coronavirus, SARS, [키워드] affecting aggregation ALS Amyotrophic lateral sclerosis approved cause Compound COVID-19 cysteine demonstrated develop disease disease onset dominant drug drug design Ebselen education enzyme finding funding gene encoding improvement in vitro involved Japan ligand-bound Lou Gehrig mice motor neuron motor neuron disease mutant Mutation neurodegeneration Neurological disorder neuronal cell novel offer pathogenic performed Prevent protease Riluzole Science significantly SOD1 sports stability Structure supported technology the disease therapeutic therapeutic benefits Therapeutic compounds therapeutic effect therapeutic potential these compound Toxicity transgenic Treatment utilised viral disease wild-type [DOI] 10.1016/j.ebiom.2020.102980 PMC 바로가기 [Article Type] Research paper
Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus–Host InteractionsArticle Published on 2019-08-132022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] airway epithelium Cell Cell culture Combined Culture cultures expression facilitate Factor fluorescence-activated cell sorting fluorescent functional Genetic hAEC HCoV-229E Host host gene expression Human human airway epithelial human airway epithelial cell cultures human coronavirus 229E human respiratory epithelium human respiratory virus in vitro inhibitor innate immune response Interaction knockdown lentiviral Modification modulated molecular not affected platform primary cell primary human cell Protein protocol reporter respiratory respiratory syncytial virus respiratory virus respiratory viruses target cells transgenic unique virus infection Virus-host interactions virus–host interaction Y-27632 [DOI] 10.3390/v11080747 PMC 바로가기 [Article Type] Article
Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies새로운 효모 단백병증 모델 및 유전자 변형 파리에서 PBP1/ATXN2 기능의 손실에 의해 칼슘 반응성 트랜스활성제(CREST) 독성이 구출됩니다Research Article Published on 2019-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Affect aggregate aggregation ALS Amyotrophic lateral sclerosis ATXN2 calcium caused chaperone CREST cytoplasmic degenerative Deletion disease Disease model Diseases downregulation Drosophila effective enhancer expressed facilitate foci form ganglion cell ganglion cells Genes inhibit Lateral Sclerosis Like Localization mammalian cells mechanism modify Mutation neurodegenerative neurons nuclear ortholog overexpressing overexpression phenotype Propagation Protein Proteins reduce reduced regulated required rescued risk factor shown Spectrum SS18L1 targets therapeutic target therapy Thioflavin toxic Toxicity transgenic yeast yeast form yeast forms [DOI] 10.1371/journal.pgen.1008308 PMC 바로가기 [Article Type] Research Article
Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila세포질 비호환성의 Two-By-One 모델: 초파리에서 cifA 및 cifB의 형질전환 발현에 의한 합성 요약Research Article Published on 2019-06-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Bacteria caused comparable cytoplasmic Dengue dengue viruses Drosophila Drosophila melanogaster dual Embryo embryonic embryos expression female functional Gene expression analysis Genes Genetic genetic model hypothese hypotheses implication incompatibility induce infect infections kill lethality male mechanism methodology Modification phage Population predict Release Replication reported rescue rescued responsible robust Spread Strains Support synthetic These data transgenic uninfected vector control virus viruses wild type Wolbachia Zika [DOI] 10.1371/journal.pgen.1008221 PMC 바로가기 [Article Type] Research Article
Overexpression of Chickpea Defensin Gene Confers Tolerance to Water-Deficit Stress in Arabidopsis thalianaOriginal Research Published on 2019-03-122023-08-30 Journal: Frontiers in Plant Science [Category] E형 간염, [키워드] Arabidopsis thaliana Ca-AFP defensin mannitol Polyethylene glycol transgenic water-deficit stress [DOI] 10.3389/fpls.2019.00290 PMC 바로가기 [Article Type] Original Research
The 3D8 single chain variable fragment protein suppress infectious bronchitis virus transmission in the transgenic chickensArticle Published on 2019-01-232023-06-15 Journal: Research in veterinary science [Category] MERS, [키워드] 3D8 scFv chicken Infectious Bronchitis Virus shedding transgenic [DOI] 10.1016/j.rvsc.2019.01.025 PMC 바로가기 [Article Type] Article
Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoVArticle Published on 2019-01-092022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] antibody blocked caspase-1 Cell complement contribute expression hDPP4 highly pathogenic human DPP4 human macrophages IL-1β Immunopathogenesis induce Infection Inflammation inhibiting inhibition MERS-CoV MERS-CoV infection mice Middle East mortality rate occurred overexpressed Pathogenesis pyroptosis respiratory syndrome coronavirus serum spleen suppressed THP-1 transgenic virus [DOI] 10.3390/v11010039 PMC 바로가기 [Article Type] Article