HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodiesHYBRiD: 포유류의 몸을 청소하기 위한 하이드로겔 강화 DISCOArticle Published on 2022-04-012022-09-11 Journal: Nature methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] antibody Chest compatibility component components demonstrated dimensions DISCO feature fluorescent hACE2 heterogeneous hybrid immunostaining K18-hACE2 transgenic mice macroscopic mammalian mice nervous system Newborn offer organ organic parvalbumin Protein reporter Research SARS-COV-2 infection solvent three dimensions translational utility Viral viral pathology Visualization [DOI] 10.1038/s41592-022-01427-0 PMC 바로가기 [Article Type] Article
Epicardial adipose tissue in contemporary cardiology Reviews Published on 2022-03-162022-10-05 Journal: Nature reviews. Cardiology [Category] 바이오마커, [키워드] addition adipose agonist Anatomy Atrial fibrillation benefit cardiovascular disease contribute Coronary Coronary artery disease coronavirus disease Cytokines drug fat heart failure highlight inhibitors interest involved Myocardium paracrine Pathogenesis peptide physiological potential therapeutic target pro-inflammatory progression Protective provide receptor Research review risk factor secretion Secretome syndrome tissue Transcriptome translational unique [DOI] 10.1038/s41569-022-00679-9 [Article Type] Reviews
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 ExpressionK18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다Article Published on 2022-03-052022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viremia Virological [DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소Original Article Published on 2022-03-052022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor airway airway epithelial cell airway epithelial cells Airway inflammation Analysis analyzed antagonism antagonist antagonists approved assays B2R-antagonist Bronchial epithelium cellular clinical study complex controls COVID-19 Critical cytotoxicity early-stage COVID-19 entry receptor epithelial epithelial cells Evidence Ex vivo expression of SARS-CoV-2 Future G protein Host Icatibant immune regulation in vitro in vivo in vivo model induction Infection information inhibiting inhibiting viral replication Interference Kallikrein Kinin Kinin-kallikrein-system mechanism murine nasal nasal mucosa negative nose pathway performed Plaque assay plaque assays PROTECT protection provide receptor receptor signaling reduce reduced reduction Replication RT-qPCR SARS-CoV-2 SARS-CoV-2 entry receptor SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2-positive patients Signaling Spread study participant Study participants supplementary material symptomatic Transcriptome transcriptomes translational Transport treated Treatment upregulation Vero-E6 cells Viral viral replication were infected [DOI] 10.1007/s00109-022-02182-7 PMC 바로가기 [Article Type] Original Article
Establishing CREATE: lessons learned in setting up a training environment for early-career researchers in respiratory medicineResearch Published on 2022-03-012022-10-28 Journal: BMC Medical Education [Category] Coronavirus, MERS, SARS, [키워드] association Australia clinician Cohort Community COVID-19 distribution Early-career Establishing FIVE flexible Genetic Health Health and medical research IMPROVE include involved Laboratory lesson Medical Research Council National offered participant Patient professional development Program promote provided pulmonary pulmonary fibrosis Research researcher researchers Result seeking Seven supplementary material supported training translational Travel unique [DOI] 10.1186/s12909-022-03169-1 PMC 바로가기 [Article Type] Research
Rapid research response to the COVID-19 pandemic: perspectives from a National Institute for Health Biomedical Research CentreCommentary Published on 2022-02-192022-10-31 Journal: Health Research Policy and Systems [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] benefit Biomedical Research Centres COVID-19 COVID-19 pandemic COVID-19 research creating Critical death England facilitate global pandemic individual level National Health Service NIHR organization organizational resilience Oxford Patient Perspective public health Rapid Rapid research response Research researcher resource resources respond supported translational Translational research Treatment [DOI] 10.1186/s12961-022-00827-0 PMC 바로가기 [Article Type] Commentary
Reflections on Experiencing Parental Bereavement as a Young Person: A Retrospective Qualitative StudyArticle Published on 2022-02-132022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] age amplified analysed Anxiety bereavement children conducted Consequences COVID-19 pandemic death Depression distance emotion emotional Enabling engage female grief growth highlighting investigated Isolation lack life occurred parent parental physical post-traumatic growth public health Qualitative Reflection Research responses Result Support talking thematic analysis therapy translational Trigger young person [DOI] 10.3390/ijerph19042083 PMC 바로가기 [Article Type] Article
Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion423 Published on 2022-02-112022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 40S 5′ UTR Antisense oligonucleotide antiviral immunity block bypassing C-terminal domain circumvent Concentration conserved COVID-19 COVID-19 pandemic Critical drug resistance effective therapy evade expressing Health highly pathogenic Host host protein human ACE2 infected cell inhibit interfere maintain mechanism Messenger RNA mRNA mRNA stability nonstructural protein 1 nucleic acid pathogenicity presenting PROTECT protein trafficking Replication SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2–infected mice sequence Significance suppress susceptible targeting the SARS-CoV-2 therapeutic therapeutic target transgenic mice translation translational unique Vaccines variants variants of SARS-CoV-2 Viral protein viral replication virulence virus [DOI] 10.1073/pnas.2117198119 PMC 바로가기 [Article Type] 423
Placental Macrophage (Hofbauer Cell) Responses to Infection During Pregnancy: A Systematic Scoping ReviewImmunology Published on 2022-02-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] age Bacterial Cell cells clinical Complication congenital congenital infection extracellular trap Final gestation Hofbauer cells identify Immune cell in vitro study Infection information investigated involved limit LPS Macrophage macrophages majority mechanism morbidity and mortality neutralization objective observation outcome PAMP PAMPs pathogen Pathogens pattern phagocytosis Placenta placental Placental infection placental macrophages pre-existing immunity Pregnancy Preterm birth profiles rationale replicate respond response review searched secretion transcriptional translational Transmission variety virus [DOI] 10.3389/fimmu.2021.756035 PMC 바로가기 [Article Type] Immunology
Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cellResearch Article Published on 2022-02-022022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] 229E acute respiratory syndrome addition antibiotic Antiviral antiviral activity binding brilacidin Cell culture cell cultures cell entry clinical trial combination therapy coronavirus COVID‐19 COVID19 Defense drug drug candidate heparin Host host cell host cell surface HSPGs human coronavirus inhibit inhibitory activity mechanism mechanism of action multiple cell line multiple cell lines NL63 OC43 peptide Phase 2 Proteoglycan provide pseudovirus Remdesivir reported SARS‐CoV‐2 SARS‐CoV‐2 synergistic translational virucidal virus [DOI] 10.1002/jmv.27616 PMC 바로가기 [Article Type] Research Article