Novel and flexible ultrasound simulation with smartphones and tablets in fetal echocardiographyMaternal-Fetal Medicine Published on 2021-06-042022-10-27 Journal: Archives of gynecology and obstetrics [Category] Coronavirus, MERS, SARS, [키워드] addition age COVID-19 pandemic examined fetal fetal echocardiography flexible Gender identify increasingly knowledge less median medical education no significant difference novel patients performed physiological Portable ultrasound simulation proportion Prospective Result significantly significantly higher Structure structures Tablet two group Two-arm Ultrasound education Ultrasound simulator were given [DOI] 10.1007/s00404-021-06102-x PMC 바로가기 [Article Type] Maternal-Fetal Medicine
Effects of a multi-faceted education and support programme on anxiety symptoms among people with systemic sclerosis and anxiety during COVID-19 (SPIN-CHAT): a two-arm parallel, partially nested, randomised, controlled trialResearch article Published on 2021-06-012022-10-05 Journal: The Lancet Rheumatology [Category] 임상, [키워드] 1:1 95% CI activity adverse event Affect age allocation to intervention analysed Anxiety anxiety symptom anxiety symptoms assigned baseline Canada Complete Controlled trial coping strategies COVID-19 Depression Effect Effectiveness eligible Emergency evaluate the effect finding funding group IMPROVE initiative Intention-to-treat analyses intention-to-treat population International Intervention Isolation mean difference measure mental health Mild network New outcome participant Participants Patient positive post-intervention Pragmatic Primary outcome Program programming provided public health randomised Randomly receiving recruited reduce reduced Registered reported Scleroderma secondary outcome significantly significantly lower SMD Society South Support Symptom Systemic sclerosis tested Trial Two-arm two-arm parallel white women [DOI] 10.1016/S2665-9913(21)00060-6 [Article Type] Research article
Assessing efficacy of antiviral therapy for COVID-19 patients: A case study on remdesivir with bayesian synthesis design and multistate analysisCOVID-19 환자에 대한 항바이러스 요법의 효능 평가: 베이지안 합성 설계 및 다중 상태 분석을 사용한 렘데시비르에 대한 사례 연구Article Published on 2021-06-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 치료제, [키워드] 95% CI Analysis antiviral therapy applied Assessing Bayesian Bayesian synthesis sequential design case study clinical Clinical efficacy COVID-19 COVID-19 patient death discharge Disease progression Efficacy empirical evidence Evidence High-risk patients Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients medium Mortality outcome outcome measure outcome measures Patient patients with COVID-19 progression reducing reducing mortality reduction Remdesivir required risk of death sequential design significantly shorter standard care group statistically significant subsequent therapy treated treated patient Trial Two-arm [DOI] 10.1016/j.jfma.2021.04.026 PMC 바로가기 [Article Type] Article
Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: study protocol for a randomized controlled trial치료 중인 암 환자의 COVID-19 예방에 대한 하이드록시클로로퀸의 효과: 무작위 대조 시험을 위한 연구 프로토콜Update Published on 2021-05-192022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 age assigned blinded Blinding blocks breast and colon cancer calculated Cancer cancer patient Cancer patients Caregivers Colon cancer color company comparator Patients control group Controlled trial coronavirus disease COVID-19 COVID-19 symptom COVID-19 symptoms curative intent Effect examined FIVE follow-up period high resolution Hydroxychloroquine incidence of COVID-19 Intervention investigated Iran leukemia lung Lungs lymphoid Mashhad Medical Sciences Nasopharyngeal swab non-Hodgkin’s lymphoma Novel coronavirus novel coronavirus disease objective occur outcome parallel-group participant Patient patients performed pharmaceutical Pharmaceutical Company Placebo primary end point produced Prophylactic random randomization sequence Randomized controlled trial Randomly receiving regimens RT-PCR Sample Sample size SARS-CoV-2 virus shape Study protocol supplementary material Symptom Tablet the patient tomography total sample size treated Treatment triple-blind two group two groups Two-arm university website [DOI] 10.1186/s13063-021-05292-8 PMC 바로가기 [Article Type] Update
A two-arm, randomized, controlled, multi-centric, open-label phase-2 study to evaluate the efficacy and safety of Itolizumab in moderate to severe ARDS patients due to COVID-19COVID-19로 인한 중등도에서 중증 ARDS 환자에서 이톨리주맙의 효능과 안전성을 평가하기 위한 2군, 무작위, 대조, 다중 중심, 공개 라벨 2상 연구Clinical Trial Published on 2021-05-012022-09-12 Journal: Expert opinion on biological therapy [Category] MERS, SARS, 임상, 진단, [키워드] 95% CI acute respiratory distress acute respiratory distress syndrome anti-CD6 ARDS Complete coronavirus COVID-19 COVID-19 patient COVID-19 patients cytokine release Cytokine release syndrome death effective Efficacy and safety Enrollment evaluate evaluated events FiO2 FIVE IL-6 immune immune hyperactivation immunomodulatory immunomodulatory therapy Immunotherapy itolizumab lymphopenia mAb moderate necrotic objective Open-label outcome PaO2 Patient patients Randomized reaction receiving reduction in reduction in mortality replaced reported Result Safe screened severe ARDS SpO2 supportive care survival syndrome Transient treated Treatment Two patient Two-arm [DOI] 10.1080/14712598.2021.1905794 PMC 바로가기 [Article Type] Clinical Trial
The impact of theory-based messages on COVID-19 vaccination intentions: a structured summary of a study protocol for a randomised controlled trial이론 기반 메시지가 COVID-19 백신 접종 의도에 미치는 영향: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-292022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 allocation approach automatically blinded Blinding comparator Contact contact with COVID-19 COVID-19 illness COVID-19 vaccination COVID-19 vaccine creating dissemination element ethnic group exposure to Follow-up Gender hypothesised illness beliefs Image individual individually randomised information initiate Intention Intervention investigator investigators messaging minute Necessity-Concerns Framework number objective online survey software outcome oversampling pandemic participant Participants performed post-intervention proportion Prospective protocol randomised randomised controlled trial receive reported Sample size secondary Secondary outcomes Side effect Side effects status Study protocol supplementary material treatment beliefs Trial Trial registration two group two groups Two-arm uptake vaccination vaccination against COVID-19 vaccination intention Vaccine vaccine for COVID-19 Vaccine hesitancy variable website [DOI] 10.1186/s13063-021-05277-7 PMC 바로가기 [Article Type] Letter
Supporting Parents & Kids Through Lockdown Experiences (SPARKLE) : A digital parenting support app implemented in an ongoing general population cohort study during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trialLockdown Experiences(SPARKLE)를 통해 부모와 자녀 지원 : COVID-19 전염병 동안 진행 중인 일반 인구 집단 연구에서 구현된 디지털 육아 지원 앱: 무작위 통제 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-102022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 adverse events Analysis automatically baseline baseline characteristics blind blinded Blinding changes in Child behaviour problems children clinical Cohort cohort study collected Community comparator Complete Controlled trial COVID-19 difficulty Digital health dissemination Effect Efficacy eight element eligible enrolled exacerbated examined experience Exploratory analyses facilitated Families FAU General population Graphics help implementation individual information Intervention lockdown longitudinal cohort study measure mental health moderate number objective on children outcome outcomes pandemic parallel group parent Parenting parents participant platform Pragmatic Primary outcome problem protocol provided public health Public health intervention Qualtrics randomisation randomised randomised controlled trial receive recruited reduce Registered reported Research resources Sample size selected senior statistician Space Standard Stratification strength Stress Study protocol supplementary material Support Supporting text treatment arm Trial Two-arm Usage was selected website [DOI] 10.1186/s13063-021-05226-4 PMC 바로가기 [Article Type] Letter
Primary Care implementation of Germ Defence, a digital behaviour change intervention to improve household infection control during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trialCOVID-19 전염병 동안 가정 감염 통제를 개선하기 위한 디지털 행동 변화 개입인 Germ Defence의 1차 진료 구현: 무작위 통제 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-092022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 antibiotic Behaviour change blinded Blinding block blocks Bristol Care clinical Cluster collaboration Commission comparator Contact Controlled trial coronavirus COVID-19 COVID-19 symptom detect diagnose Digital health Digital medicine dissemination Effect effect size Effectiveness element engage England enrolment Gastrointestinal infection gastrointestinal infections general practices Germ group hand washing help Hospital admission hygiene identity implementation IMPROVE incidence incidence of COVID-19 include independent individual Infection infection control Infectious disease Intervention intervention arm involved ISRCTN ISRCTN registry management measure number objective outcome overcome participant Patient personalised Prevalence primary care Primary outcome Principal Investigators problem problem solving protection protocol randomisation randomised randomised controlled trial Randomly receive reduce Registered respiratory respiratory tract infection Sample size secondary outcome Secondary outcomes Spread Stata Statistical Software statistical statistician Study protocol supplementary material Symptom Trial Trial registration Two-arm usual care website [DOI] 10.1186/s13063-021-05188-7 PMC 바로가기 [Article Type] Letter
The ARREST Pneumonia Clinical Trial. Rationale and DesignRandomized Controlled Trial Published on 2021-04-012022-10-05 Journal: Annals of the American Thoracic Society [Category] SARS, 임상, [키워드] acute respiratory distress addition Administered aerosol drug therapy ARF arrest clinical Combination composite endpoint death defined demonstrated double-blinded early treatment effective Efficacy Enrollment failure feasibility heart high risk Hospital stay Hospitalized IMPROVE inhaled corticosteroid intubation mechanism Mortality nasal Noninvasive ventilation Oxygen therapy Oxygenation participant Patient patients hospitalized Placebo placebo-controlled trial plasma biomarker Pneumonia preliminary finding prevention Primary outcome question randomization Randomized randomized clinical trial rationale recent reduce reducing Registered respiratory Respiratory failure Respiratory Support risk selected severe pneumonia syndrome Systemic steroid therapy Trial Two-arm [DOI] 10.1513/AnnalsATS.202009-1115SD PMC 바로가기 [Article Type] Randomized Controlled Trial
Improving racial disparities in unmet palliative care needs among intensive care unit family members with a needs-targeted app intervention: The ICUconnect randomized clinical trialRandomized Controlled Trial Published on 2021-04-012022-10-05 Journal: Contemporary clinical trials [Category] SARS, 임상, [키워드] Anxiety Arm assist baseline black Black patient Care clinical impact clinical trial clinician concerning Concordance conducted COVID-19 pandemic Critical illness determine EHR Electronic health record Electronic health record (EHR) systems enrolled Health healthcare Hierarchical ICU ICU Patients ICUs Improving include intensive care intensive care units interaction term Intervention intervention effect Linear model manuscript Mobile Mobile App outcome palliative Palliative care parallel group participant physician Post-traumatic stress disorder Primary outcome Psychological distress Racial Racial health disparities Randomized randomized clinical trial Randomized clinical trial (RCT). RCT receive reduce reducing remained resource secondary symptoms of depression their family members treat Two-arm usual care white [DOI] 10.1016/j.cct.2021.106319 PMC 바로가기 [Article Type] Randomized Controlled Trial