A metagenomic DNA sequencing assay that is robust against environmental DNA contamination환경 DNA 오염에 강한 메타게놈 DNA 시퀀싱 분석Article Published on 2022-07-212022-09-11 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] applied Blood Co-infection Contamination COVID-19 DNA DNA sequencing identify Infection Inflammatory bowel disease introduced Isolation lAbel metagenomic metagenomic sequencing microbial Microbial communities microbial community Microbiome microorganism microorganisms powerful tool recorded robust Sepsis Sequencing SIFT Tagging Urine [DOI] 10.1038/s41467-022-31654-0 PMC 바로가기 [Article Type] Article
Alterations in the molecular composition of COVID-19 patient urine, detected using Raman spectroscopic/computational analysis라만 분광/전산 분석을 사용하여 감지한 COVID-19 환자 소변의 분자 구성 변화Article Published on 2022-07-182022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Abnormalities Accuracy affected alteration Analysis analyzed Bladder cancer Care Chain Reaction Chromatography Clinical pathology collected complex component components computational analysis Contact contact with contributing to correlation correlations COVID-19 COVID-19 disease COVID-19 patient creatinine defined detect determine disease disease severity EGFR elevated fingerprint gas chromatography Gas Chromatography-Mass Spectrometry GC-MS glomerular filtration rate healthy healthy individual healthy individuals Hospitalized HPLC identify in urine include Infection Inflammatory liquid Liquid chromatography Long mass spectrometry metabolomic analysis Mild moderate molecular Negative predictive value pathology Patient patients performance Peritoneal dialysis positive Positive predictive value Predictive value Raman spectroscopy random ranged reaction representing respiratory RT-PCR SARS-CoV-2 virus sensitivity serum creatinine severity specificity specimen specimens Spectrometry Symptom symptomatic tested Urinalysis Urine urine specimens Viral Volunteer with COVID-19 [DOI] 10.1371/journal.pone.0270914 PMC 바로가기 [Article Type] Article
Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the COVID-19 PandemicMetagenomic 차세대 시퀀싱은 COVID-19 팬데믹 기간 동안 신장 이식 수혜자의 바이러스 감염 프로필을 보여줍니다Article Published on 2022-07-112022-09-11 Journal: Frontiers in Public Health [Category] 치료기술, [키워드] Analysis BALF Biomarker Blood Blood samples Bronchoalveolar lavage fluid CMV compared and analyzed COVID-19 COVID-19 pandemic cytomegalovirus database detection rate dominant higher risk IMPROVE indicated Infection JC polyomavirus kidney kidney transplant recipient kidney transplant recipients Kidney transplantation metagenomic Metagenomic next-generation sequencing Next-generation sequencing nucleic acid nucleic acids profile recipient rejection reveal sequence simian virus torque teno virus Transplant Urine viral infection viral infections viral nucleic acid viral nucleic acids virus virus infection viruses [DOI] 10.3389/fpubh.2022.888064 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
Insights to estimate exposure to regulated and non-regulated disinfection by-products in drinking water Research Published on 2022-06-292022-10-05 Journal: Journal of Exposure Science & Environmental Epidemiology [Category] 바이오마커, [키워드] activated Activated carbon analyzed Barcelona Chlorate collected Concentration concentrations correlated DBP Effect epidemiological studies explained filtered finding Health Impact information insight Linear model Linear regression Linear regression model machine learning models median multivariate number of sample objective Occurrence participant predict Predictive Predictive model quantified Questionnaires reduced regulated Replication Result Significance Spain study population tap THM total variance Urine validation variable [DOI] 10.1038/s41370-022-00453-6 [Article Type] Research
COVID-19 Pandemic Impacts on Humans Taking Antibiotics in ChinaArticle Published on 2022-06-212022-11-16 Journal: Environmental science & technology [Category] COVID19(2023년), SARS, 치료기술, [키워드] adverse effects Antibiotics Bacterial changes in China collected Concentration confirmed cases COVID-19 COVID-19 pandemic elevated examined geographical region gut microbiota Health Human identify Impact imperative Medicines Novel coronavirus outbreak pandemic profile public health Region regional distribution Research Taking Urine [DOI] 10.1021/acs.est.1c07655 PMC 바로가기
Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19소변 대사체학은 트립토판-키누레닌 경로의 조절 장애를 COVID-19의 염증 및 중증도와 연결합니다Article Published on 2022-06-152022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] 3-hydroxykynurenine alteration Amino acid amino acids association Biomarker Biomarkers cause changes in Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Critical disease severity dysfunction dysregulation healthy controls; Host immune response Increased Inflammation investigated Kynurenine kynurenines metabolism metabolite metabolomic profiling metabolomics Neutral pathway patients hospitalized performed proline proximal proximal tubule Quantitative SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection serum severity severity of COVID-19 Support systemic inflammation Transport Tryptophan Urine with COVID-19 [DOI] 10.1038/s41598-022-14292-w PMC 바로가기 [Article Type] Article
Clinical and subclinical acute kidney injury in children with mild-to-moderate COVID-19 Research Published on 2022-06-092022-10-05 Journal: Pediatric Research [Category] 바이오마커, 치료기술, 치료법, [키워드] Acute kidney injury Admission AKI Biomarker children clinical Combination Course COVID-19 criteria cross-sectional develop Diagnosis diagnosis of COVID-19 disease course evaluated functional group healthy children healthy control Hospitalized identify IL-18 Impact IMPROVE increased risk Inflammation İstanbul KDIGO Kidney injury laboratory feature marker Mild Mild-to-moderate Moderate COVID-19 moderate disease neutrophil count outcomes Patient predictor Result reveal risk serum creatinine severe disease significantly higher urinary Urine [DOI] 10.1038/s41390-022-02124-6 [Article Type] Research
The COVID-19 pandemic – what have urologists learned?COVID-19 전염병 - 비뇨기과 전문의는 무엇을 배웠습니까?Review Published on 2022-06-012022-09-11 Journal: Nature reviews. Urology [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, [키워드] ACE2 Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting AKI androgen angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused cell damage changes in clinical study Complication complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic damage Deprivation Economy expressed genitourinary tract high risk hypogonadism impairment in urine Invasion organ organs outbreak pandemic patients with COVID-19 public health raising receptor reported respiratory tract SARS-CoV-2 secondary hypogonadism Semen severe acute respiratory syndrome Coronavirus spermatogenesis survival Symptom testes Testosterone the WHO therapy tract treating COVID-19 Urine [DOI] 10.1038/s41585-022-00586-1 PMC 바로가기 [Article Type] Review
Respiratory etiological surveillance among quarantined patients with suspected lower respiratory tract infection at a medical center in southern Taiwan during COVID-19 pandemicCOVID-19 전염병 동안 대만 남부의 의료 센터에서 하기도 감염이 의심되는 격리된 환자의 호흡기 병인 감시Article Published on 2022-06-012022-09-11 Journal: Journal of microbiology, immunology, and infection [Category] 바이오마커, 치료기술, [키워드] accounted Antigen Atypical Bacteria Bacterial Bacterial infection bacterial pathogen Bacterial pathogens Biomarkers caused Chain Reaction clinical manifestation clinical manifestations Combination conducted COVID-19 COVID-19 pandemic Culture Decision making Diagnosis ENhance enrolled etiological etiologies etiology hospital Infection Legionella Lower respiratory tract lower respiratory tract infection median age Microbial etiology multiple comorbidities multiplex Multiplex PCR nursing home pandemic Panel pathogen Pathogens Patient Patient care PCR pneumococcus polymerase chain polymerase chain reaction prevalence of COVID-19 quarantine quarantined patient respiratory respiratory pathogen Respiratory pathogens respiratory virus serologic surveys sputum sputum culture Surveillance Taiwan tested Total Urine Viral antigen virus [DOI] 10.1016/j.jmii.2021.07.009 PMC 바로가기 [Article Type] Article