Successful Clearance of 300 Day SARS-CoV-2 Infection in a Subject with B-Cell Depletion Associated Prolonged (B-DEAP) COVID by REGEN-COV Anti-Spike Monoclonal Antibody Cocktailregen-cov 항-스파이크 모노클로 날 항체 칵테일에 의한 B- 세포 고갈 관련 장기 (B-DEAP) covid에서 300 일 SARS-COV-2 감염의 성공적인 허가Case Reports Published on 2021-06-232022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] anti-CD20 anti-CD20-mediated B-cell depletion anti-COVID-19 vaccine anti-SARS-CoV-2 vaccination anti-spike monoclonal antibodies anti-spike monoclonal antibody B-cell B-cell depletion associated prolonged COVID-19 B-DEAP COVID-19 Care Chemotherapy clearance Clinical course clinical decision cocktail consolidation coordination COVID COVID-19 COVID-19 infection current Day Depletion develop Diagnosis disappearance dose failure FDA first dose follicular Follicular lymphoma Health Health care Hospitalized Humoral immunity immunology Infection infused infusion initial input IRB lymphoma male management Mild monoclonal antibodies monoclonal antibody mutations obinutuzumab Patient persistence Pfizer-BioNTech Pharmacology Prolonged quarantine REGEN-COV REGN10933 and REGN10987 required SARS-CoV-2 SARS-CoV-2 persistence SARS-CoV-2 virus spike mutation the patient therapeutic option therapy treated vaccination Virology virus clearance virus mutations was performed [DOI] 10.3390/v13071202 PMC 바로가기 [Article Type] Case Reports
Aging and respiratory viral infection: from acute morbidity to chronic sequelaeReview Published on 2021-06-222022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] aging alteration antiviral immune response benefit cellular and molecular contributing to COVID-19 COVID-19 pandemic driving homeostasis Host immune immune characteristics immune response increased risk influenza virus infection knowledge mechanism morbidity morbidity and mortality Patient care respiratory viral respiratory viral infections Respiratory virus infections Treatment unique virus clearance [DOI] 10.1186/s13578-021-00624-2 PMC 바로가기 [Article Type] Review
Relative COVID-19 Viral Persistence and Antibody KineticsArticle Published on 2021-06-132022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] antibody Antibody Response average chemokine comparable Concentration COVID-19 COVID-19 patient cytokine profile Deceased early stage effective Efficacy eight elevated hospital Human Kinetics less neutralization neutralization efficacy outbreak Patient patients post-symptom onset Proinflammatory cytokine PSO relative RT-PCR Screening sera serum antibody Seven severe disease survived Taiwan viral clearance viral persistence virus virus clearance Virus neutralization [DOI] 10.3390/pathogens10060752 PMC 바로가기 [Article Type] Article
Thymosin Alpha-1 Has no Beneficial Effect on Restoring CD4+ and CD8+ T Lymphocyte Counts in COVID-19 PatientsImmunology Published on 2021-06-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] age baseline CD4 benefit cancers CD4 CD4 counts CD4+ CD8 CD8+ CD8+ T cell Clinical Center conducted count COVID-19 COVID-19 patient COVID-19 patients Critically ill Effect Efficacy evaluate homeostasis hypertension immune response immune system Infection investigated laboratory characteristics Linear regression analysis longitudinal change males management multivariate no significant difference no statistical difference observé Older Patient patients phenotype public health reduction Restoring Retrospective study severity Shanghai significantly subset T lymphocyte the median the patient therapy thymosin alpha 1 thymosin alpha-1 treated two group upper respiratory tract virus virus clearance [DOI] 10.3389/fimmu.2021.568789 PMC 바로가기 [Article Type] Immunology
Systemic Corticosteroid Administration in Coronavirus Disease 2019 Outcomes: An Umbrella Meta-Analysis Incorporating Both Mild and Pulmonary Fibrosis–Manifested Severe DiseasePharmacology Published on 2021-05-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] administration adverse event AEs Analysis association benefit caution Clinical improvement Clinical practice Confidence intervals coronavirus coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient critically ill/pulmonary fibrosis manifested database dose Effect effect size Efficacy Egger’s test eligible evaluated Evidence fixed hospital Hospital stay Hospitalization ICU intensive care intervals mechanical ventilation Mortality Negative conversion outcome Patient pulmonary Random-effects models reduction in mortality risk reduction searched sensitivity analysis systemic Treatment UMBRELLA umbrella meta-analysis virus clearance [DOI] 10.3389/fphar.2021.670170 PMC 바로가기 [Article Type] Pharmacology
Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infectionResearch Article Published on 2021-05-242022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Adaptive immune response anti-inflammatory cytokine anti-inflammatory effect antiviral drug Asymptomatic Asymptomatic carriers CCL2 CCL3 chemokine clearance clinical manifestation Concomitant contribute correlated Cytokine storm disease driving effective elicited epithelia etiological agent expression feature high mortality Host humans IFN IL10 immune response gene immunological pathway Infection Infectious virus infiltration Inflammation Inflammatory responses innate immune response interferon interferon response interferons (IFNs ISG ISGs lethal disease leukocyte leukocytes lung MERS-CoV MERS-CoV infection Middle East Mild mucosa nasal nasal mucosa NF-κB post inoculation pro-inflammatory cytokine pro-inflammatory gene produced provoke Regulation reservoir Respiratory disease respiratory syndrome coronavirus respiratory tract Simultaneous stimulated syndrome tissue damage tissues transcribed Transcription transcriptional regulation triggering Type type I Type III IFN understanding upregulation Vaccines viral infection virus virus clearance while [DOI] 10.1371/journal.ppat.1009229 PMC 바로가기 [Article Type] Research Article
Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With Coronavirus Disease 2019 (COVID-19; Metcovid): A Randomized, Double-blind, Phase IIb, Placebo-controlled TrialRandomized Controlled Trial Published on 2021-05-042022-10-05 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] 1:1 28-day mortality acute respiratory syndrome Analysis analyzed assigned Brazil Care clinical clinical trial conducted coronavirus coronavirus disease Corticosteroid Course COVID-19 Day did not reduce double-blind drug Efficacy epidemiological evaluate groups hospitalized patient IIb individual Inflammation Inflammatory response Insulin therapy intravenous lower mortality Lungs Methylprednisolone mITT modified intention-to-treat Mortality mortality rate no difference not different Patient phase Placebo placebo-controlled polymerase chain Primary outcome radiological Randomized Randomly receive saline solution SARS-CoV-2 SARS-COV-2 infection screened secretion steroid subgroup analysis transcriptase Trial triggered virus clearance was performed with COVID-19 [DOI] 10.1093/cid/ciaa1177 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comprehensive evaluation of the efficacy and safety of LPV/r drugs in the treatment of SARS and MERS to provide potential treatment options for COVID-19COVID-19에 대한 잠재적인 치료 옵션을 제공하기 위해 SARS 및 MERS 치료에서 LPV/r 약물의 효능 및 안전성에 대한 종합 평가Meta-Analysis Published on 2021-04-302022-09-10 Journal: Aging (Albany NY) [Category] MERS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome addition adverse event adverse events age and sex analyzed Antiviral treatment applied ARDS assessment tool benefit bias risk case-control studies CBM Chest CT China CNKI Cochrane Library Cohort studies Combination comprehensive evaluation conducted control group conversion rate coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 treatment database drug effective Effectiveness Efficacy Efficacy and safety eligible evaluate exhibited Factor incidence Infrastructure literature Lopinavir Lopinavir/ritonavir lower mortality LPV/r MERS Meta-analysis Middle East Middle East respiratory syndrome molecular Newcastle-Ottawa Scale NOS nucleic acid outbreak outcome patients patients with COVID-19 patients with SARS performed potential treatment option prognostic Randomized controlled studies RCT reduced Registration respiratory respiratory distress retrieved Risk assessment Ritonavir SARS Severe acute respiratory syndrome significantly similarities similarity statistically significant Structure syndrome systematic review the Newcastle-Ottawa Scale these viruses Treatment treatment of COVID-19 Trial two group two groups virus clearance viruses was used were used [DOI] 10.18632/aging.202860 PMC 바로가기 [Article Type] Meta-Analysis
Multicentre randomised double-blinded placebo-controlled trial of favipiravir in adults with mild COVID-19경증 COVID-19 성인을 대상으로 한 favipiravir의 다기관 무작위 이중 맹검 위약 대조 시험Article Published on 2021-04-142022-09-11 Journal: BMJ Open [Category] 임상, [키워드] 1:1 Affair approved blinded by mouth caused clinical clinical trials control group Coronavirus infection COVID-19 COVID-19 sample Cox proportional hazard regression decrease diagnosed disease onset double-blind double-blinded dropout rate Efficacy and safety Eligible participants Ethics evaluate the effect evaluated Evidence Favipiravir follow-up period followed by hazard ratio healthcare hypothesise Infectious diseases institutional review board intention to treat International King lack limit medication men Mild Ministry of Health mouth nonpregnant Novel coronavirus outbreak outcome participant Patient PCR PCR test peer-reviewed per day physician Placebo placebo-controlled trial positive potential therapy primary analysis population Primary outcome randomised Randomised trial recruit recruited registration number registry reported required Respiratory illness SARS-CoV-2 subject swab sample symptomatic patient Symptomatic patients the timing therapeutic agent Therapeutics therapy treat treated Treatment Virology virus virus clearance women [DOI] 10.1136/bmjopen-2020-047495 PMC 바로가기 [Article Type] Article
Comparative analysis of various clinical specimens in detection of SARS-CoV-2 using rRT-PCR in new and follow up cases of COVID-19 infection: Quest for the best choice코로나19 신규 및 후속 감염 사례에서 rRT-PCR을 이용한 SARS-CoV-2 검출 시 다양한 임상 검체의 비교 분석: 최선의 선택을 위한 탐구Research Article Published on 2021-04-052022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] affected Analysis average Chain Reaction Combined Comparative analysis COVID-19 COVID-19 treatment Ct values cycle threshold demographic Diagnosis diagnosis and monitoring diagnostic disease evaluate evaluated female Follow-up followed by help high viral load hour Implementing in urine indicate initial initiation of treatment lowest male management nasopharyngeal Nasopharyngeal swab nCoV Novel coronavirus NPs ORF1b oropharyngeal swab pandemic patients physician plasma polymerase chain reaction quest Randomly RdRP Result rRT-PCR SARS-CoV-2 selected serum specimen specimens sputum Swab symptomatic case time Treatment Urine utility Viral Viral load virus clearance [DOI] 10.1371/journal.pone.0249408 PMC 바로가기 [Article Type] Research Article