Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall ResponseSARS-CoV-2 감염 및 백신 회수 반응 이후 중간 기억 B 세포의 지속적인 유지Article Published on 2022-08-102022-09-12 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed antibodies antibody Antigen B cell B cell response booster CD21 CD27 CD4 CD4+ CD4+ T cell Cell correlated COVID-19 demonstrated determine elicited help highlight immune response Immunity immunization individual level infected individual Infection intermediate Kinetics Longevity longitudinal maintain maintenance memory B memory B cell memory B cells neutralization Neutralizing antibodies neutralizing antibody Pandemics persistence persistent phenotype Postinfection Protective Protein recall receptor recovered respond response SARS-CoV-2 SARS-COV-2 infection secreted significantly spike T cells the SARS-CoV-2 triggered vaccination [DOI] 10.1128/jvi.00760-22 PMC 바로가기 [Article Type] Article
Exploring the mechanism of action of Xuanfei Baidu granule (XFBD) in the treatment of COVID-19 based on molecular docking and molecular dynamicsArticle Published on 2022-08-102022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acting Activation alleviate Analysis analyzed Anti-inflammatory effects Apoptosis Baidu binding binding energy binding free energy bioinformatics Bioinformatics analysis carried chemotaxis clinical symptom Clinical symptoms Combination component Corona COVID-19 CSF2 database disease docking effective gene target GeneCard hydrogen bonds immune response Immunity IMPROVE Inflammation inflammatory cell Inflammatory factor Inflammatory response ingredient inhibiting Intersection KEGG Lymphocytes mechanism mechanism of action molecular molecular docking molecular dynamics monomer NLRP3 Pachypodol pandemic Patient platform Protein protein targets radius of gyration reduce Research residue SARS-COV-2 infection screened signaling pathway significantly solvent stability targets TCMSP database therapeutic treating COVID-19 Treatment was used White blood cell Xuanfei Baidu granule [DOI] 10.3389/fcimb.2022.965273 PMC 바로가기
Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposureArticle Published on 2022-08-102022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] accompanied analyzed anti-SARS-CoV-2 IgG Anti-spike antibody level antigen-specific B cell Atypical B cell CD4 CD4 T cell Cell cellular cellular response circulating control groups correlated effector memory evaluated germinal center (GC) healthy volunteer humoral immune response Immunity induce long-lived plasma cell MBC memory memory B memory B cell memory B cell (MBC) mounted mRNA vaccination neutralizing capacity Patient patients persistent plasmablast Reactions recall reduction rheumatoid arthritis rituximab (RTX) RTX SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination second vaccination seroconverted Seven significantly spike-specific T cell Steady state therapy treated patient Treatment vaccination vaccine-mediated immunity [DOI] 10.3389/fimmu.2022.943476 PMC 바로가기
Innate Immunity and SARS-CoV-2 Vaccine Response in Hemodialysis PatientsArticle Published on 2022-08-092023-07-11 Journal: Kidney360 [Category] COVID19(2023년), [키워드] Basic science Chronic kidney disease COVID-19 dendritic cell immune response Innate immunity monocyte mRNA vaccine SARS-CoV-2 [DOI] 10.34067/KID.0002542022 PMC 바로가기
Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine doseBNT162b2 2회 접종 후 노인 인구에서 백신 획득 면역 저하 세 번째 백신 접종으로 완화Article Published on 2022-08-082022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] acquired immunity age Analysis antibody Antibody Response BNT162b2 boost cellular response Cellular responses comprehensive analysis Delta develop dose identify immune response Immunity individual individuals induce less Lower memory memory immune response mRNA vaccine Older omicron Protein Responder responses SARS-CoV-2 Spike protein sustained T cell T cell response the Spike understanding vaccination Vaccinations Vaccine vaccine dose Vaccine-induced immunity vaccinee vaccinees variant variants Wuhan strain [DOI] 10.1038/s41467-022-32312-1 PMC 바로가기 [Article Type] Article
Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections항체 의존적 증강: 바이러스 감염에 유리한 ″악″ 항체Review Published on 2022-08-082022-09-12 Journal: Viruses [Category] 진단, [키워드] acute respiratory syndrome ADE analyzed antibody Antibody-dependent enhancement caused Cell Characteristics complement coronavirus Diseases drug effective ENhance expressed facilitate Fc receptor Fc receptors immune immune response immune responses involved mechanisms modulation molecular mechanism myeloid cells NAbs neutralizing antibody Pandemics public health Transcription transcription modulation Vaccine viral infection viral pathogenicity virus virus entry virus infection [DOI] 10.3390/v14081739 PMC 바로가기 [Article Type] Review
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal modelsArticle Published on 2022-08-052022-10-06 Journal: Science (New York, N.y.) [Category] SARS, 조류인플루엔자, 진단, [키워드] acute respiratory syndrome animal model antibody Betacoronavirus conserved coronavirus demonstrated elicit elicited epitope Health immune response immunization immunodominant macaque mice mosaic neutralization PROTECT Randomly RBD RBDs response sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven spike receptor-binding domain Strains variant [DOI] 10.1126/science.abq0839 PMC 바로가기 [Article Type] Article
Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization기존 면역의 맥락에서 SARS-CoV-2 스파이크 및 수용체 결합 도메인에 대한 체액 반응은 광범위한 사베코바이러스 중화를 부여합니다Article Published on 2022-08-042022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] approved B cell response Candidates clinically coronavirus elicited Epitopes evaluated Evaluating Humoral response IgG immune immune imprinting immune response immunization Infection naïve neutralization pre-existing immunity RBD reactivity Receptor binding domain receptor binding domain (RBD) regimen sarbecovirus Sarbecoviruses SARS-CoV-2 serum spike (S). spike glycoprotein the SARS-CoV-2 vaccination vaccine candidate [DOI] 10.3389/fimmu.2022.902260 PMC 바로가기 [Article Type] Article
Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administrationIV ChAdOx1 nCov-19 투여 후 혈소판 감소증 및 비장 혈소판 유도 면역 반응Article Published on 2022-08-042022-09-11 Journal: Blood [Category] SARS, 치료기술, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus adenovirus vaccine adenovirus-based administration aggregate anatomic sites antibody antiplatelet antiplatelet antibody approach Autoimmune response Autoimmunity B-cell response binding ChAdOx1 ChAdOx1 nCoV-19 characterized circulating antibodies circulating antibody clinical entities Complication contribute coronavirus followed by glycoprotein heparin heparin-induced thrombocytopenia highlight immune response Immune thrombocytopenia in vitro in vivo model Intramuscular injection IV injection Macrophage macrophages marginal zone mechanism mice pathology Patient phagocytosed Platelet platelet activation platelet factor 4 Platelets potential mechanism prothrombotic state receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus spleen thrombocytopenia thrombosis Trigger vaccination Vaccine zone [DOI] 10.1182/blood.2021014712 PMC 바로가기 [Article Type] Article
Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings다양한 임상 환경에서 면역 저하 환자의 오미크론 변이체에 대한 동형 및 이형 면역 반응Article Published on 2022-08-042022-09-11 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] CD4 CD8 Cellular immune response clinical setting comparable controls cross-neutralization D614G Delta Delta variants disease severity dose Host humoral identify immune immune response immune responses Immunocompromised Immunocompromised patient Immunocompromised patients implication Infection magnitude neutralization neutralizing antibody omicron Organ transplant Patient patients peptide peptide pools Pseudovirus neutralization assay Re-infection recipient response responses risk of infection SARS-CoV-2 severe COVID-19 subset T-cell Response T-cell responses uninfected Vaccine variant variants [DOI] 10.1038/s41467-022-32235-x PMC 바로가기 [Article Type] Article