immune responses – Page 50 – Communicable Diseases Research

Does breastfeeding protect children from COVID-19? An observational study from pediatric services in Majorca, Spain

Observational Study

Published on 2021-10-182022-10-04
Journal: International Breastfeeding Journal [Category] MERS, SARS, 임상,

Long Term Immune Response Produced by the SputnikV Vaccine

스푸트니크 V 백신에 의해 생성된 장기 면역 반응

Article

Published on 2021-10-182022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] Activation analyzed antibody breadth cellular immune responses cellular immunity circulating variant circulating variants conserved conserved regions convalescent COVID-19 patient convalescent sera convalescent serum cytokine Cytokines domain evidenced first dose fusion fusion protein high potency HRs humoral humoral immune response immune responses immunized immunogenic induce location Long mechanism Microbiology N-terminal N-terminal domain NTD overlapping peptide peptides RBD reactivity Receptor binding domain Region Repeat response S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein serum shown Spike protein SputnikV T cells term the SARS-CoV-2 the vaccine vaccinated individual Vaccine
[DOI] 10.3390/ijms222011211 PMC 바로가기 [Article Type] Article

SARS-CoV-2: Current trends in emerging variants, pathogenesis, immune responses, potential therapeutic, and vaccine development strategies

Review

Published on 2021-10-162022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 변종, 신약개발, 유전자 메커니즘,

[키워드] Abstract ACE-2, Angiotensin-converting enzyme 2 AKI, acute kidney injury Ang II, Angiotensin II BALF, Broncho alveolar lavage fluid cGMP, Good Manufacturing Practice Characteristics coronavirus disease 19 COVID-19 COVID-19 infection COVID-19, Coronavirus disease of 2019 CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CRS, Cytokine release syndrome CT, Computed tomography CT, Cycle threshold current Cytokine storm DENV, dengue virus develop diagnostic tests dimension drugs emerging variants FDA, Food and Drug Administration FNR, False‐negative rate Genome GGOs, Ground-glass opacities global effort HAT, Human airway trypsin-like protease health emergency Health Organization HIV, Human immunodeficiency virus IBV, infectious bronchitis virus ICU, Intensive care unit IL, interleukin immune response immune responses Immunity include Infection International JEV, Japanese encephalitis virus lack LAMP, Loop-mediated isothermal amplification LF, Lactoferrin mechanism MIP1α, Macrophage inflammatory protein 1α MRI, Magnetic resonance imaging MSC, Mesenchymal Stem Cells Mutation mutations NCD, Newcastle disease virus new virus NP, nasopharyngeal NSPs, Nonstructural proteins OP, Oropharyngeal pandemic Pathogenesis pathogenicity Potential treatment Prevent problem RAS, Renin-angiotensin system RBD, Receptor binding-domain RdRp, RNA-dependent RNA polymerases Reinfection Research resulting SARS-CoV SARS-CoV-2 SARS-COV-2, severe acute respiratory syndrome coronavirus-2 severity TGF, Transforming growth factor Th17, T helper 17 the disease the SARS-CoV-2 therapeutic therapy Transmissibility treat Vaccine vaccine candidate Vaccine development Vaccines variant variants variants of SARS-CoV-2 virus VLPs, Virus-like particles VTM, Viral transport medium while WHO WNV, West Nile virus
[DOI] 10.1016/j.intimp.2021.108232 PMC 바로가기 [Article Type] Review

SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects

SARS-CoV-2 특정 기억 T 세포 에피토프가 COVID-19 회복 대상에서 확인됨

Article

Published on 2021-10-152022-09-11
Journal: Virus research [Category] SARS, 치료법,

[키워드] Activation Analysis B cell caused CD4 CD8 T cell Cell Coronaviral COVID-19 COVID-19 pandemic COVID-19 vaccine design defined ELISPOT enzyme enzyme-linked immunosorbent epitope epitope mapping Epitopes evaluated examined explicit flow cytometry followed by foundation glycoprotein HLA Hope host immunity IgG immune immune responses immunodominant epitopes immunogenic immunogenicity in some individual induce mapped memory T memory T cells mononuclear cell N protein neutralizing antibody Neutralizing antibody response neutralizing antibody responses nucleocapsid nucleoprotein Outbreaks PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells positively correlated proportion protective immunity Protein public health RBD receptor Receptor-binding domain Reinfection response robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike spike glycoprotein stimulate structural proteins subject subjects T cell T cell activation T cell epitope T cell epitopes T cell response T cell responses T cells the receptor-binding domain the S protein Therapeutics vaccination Vaccine Vaccine design virus-specific T cell virus-specific T cell responses were used
[DOI] 10.1016/j.virusres.2021.198508 PMC 바로가기 [Article Type] Article

Self-Replicating RNA Viruses for Vaccine Development against Infectious Diseases and Cancer

Review

Published on 2021-10-152022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] Administered alphavirus animal models applied approval approved Brain Cancer Cell clinical clinical settings cytoplasm development DNA dose Ebola virus Ebola virus disease evaluated expression levels extreme Hepatitis B virus HIV immune response immune responses Infectious disease Infectious diseases Influenza virus lung Melanoma mRNA ovarian Particles pathogen plasmids Prostate cancer protection protein expression replicate RNA RNA vaccine RNA viruses RNA-dependent RNA polymerase robust SARS-CoV-2 vaccine self-replicating RNA viruses shown significantly lower Single-stranded RNA viruses surface protein transgene translation Trial tumor antigen tumor regression Vaccine Vaccine development Vaccines Viral vector virus
[DOI] 10.3390/vaccines9101187 PMC 바로가기 [Article Type] Review

The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

소아에서 과염증성 다기관 염증 증후군의 자가면역 시그니처

Article

Published on 2021-10-152022-09-11
Journal: The Journal of Clinical Investigation [Category] 바이오마커, 유전자 메커니즘,

[키워드] Admission Analysis anti-Spike IgG antigenic antigens autoantibodies autoantibody autoantigen Autoimmune Autoimmune diseases Autoimmunity B cell BCR Cellular immune response children Cluster Coagulation coagulation pathways Combination complement contributing to COVID-19 Cytokines expressed Factor Genes heavy chain humoral immune responses Hyperinflammatory identify IgG IGHV immune immune responses Immunoglobulin Immunopathogenesis Inflammation inflammation markers Inflammatory Inflammatory response intensive care intensive care unit admission manifestation Mild MIS-C Multiorgan neutrophil neutrophil activation neutrophil response pathogenic pathway Patient Previous studies previous study proteomics receptor RNA sequencing SARS-COV-2 infection sequence Sequencing serum superantigen syndrome T cell T cell receptor TCR tissue damage TRBV11-2 Treatment Usage variable region
[DOI] 10.1172/JCI151520 PMC 바로가기 [Article Type] Article

Cytidine deamination-induced perpetual immunity to SAR-CoV-2 infection is a potential new therapeutic target

SAR-CoV-2 감염에 대한 시티딘 탈아미노화 유도 영구 면역은 잠재적인 새로운 치료 표적입니다

Review

Published on 2021-10-152022-09-10
Journal: International Journal of Medical Sciences [Category] MERS, SARS, 변종,

An Update on Innate Immune Responses during SARS-CoV-2 Infection

SARS-COV-2 감염 동안 타고난 면역 반응에 대한 업데이트

Review

Published on 2021-10-142022-09-10
Journal: Viruses [Category] MERS, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral cellular receptor cellular receptors characterized components Coronaviridae family coronavirus COVID-19 pandemic Cytokines Defense disrupt Effect followed by Host hypersecretion IFN-α/β IFNs immune dysfunction immune responses Innate innate immune innate immune response innate immune responses innate immune system interferons invading pathogen invading pathogens member Mortality organ injury Pathogens patients with COVID-19 potential therapeutic targets pro-inflammatory cytokines protease respiratory response responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling the Coronaviridae Type I IFN type I interferon type I interferons variety Viral
[DOI] 10.3390/v13102060 PMC 바로가기 [Article Type] Review

SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatment

RNAi에 의한 SARS-CoV-2 표적화 및 숙주 보체 억제: COVID-19 치료를 위한 두 갈래의 속임수

Review

Published on 2021-10-132022-09-10
Journal: Immunity, Inflammation and Disease [Category] 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach C3a clinical manifestation clinical manifestations complement Complement inhibitor component conjunction coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patients curtail cytokine Cytokine storm degrade detrimental Disease progression disease progression and severity downstream effective Evidence exacerbate gene regulation processes globe Host immune responses infections information inhibitor knowledge lack less Local mitigate molecules ORF Perspective preventive measure preventive measures progression Proinflammatory cytokine protective immunity Replication required respiratory Result RNA interference RNAi robust SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Spread suppress symptomatic and asymptomatic systemic immune response systemic immune responses the cytokine storm transcript transmissible variant Treatment vaccinate Vaccine variants Viral viral spread viral/retroviral virus
[DOI] 10.1002/iid3.549 PMC 바로가기 [Article Type] Review

SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

SARS – COV – 2 스파이크는 DNA 손상 복구를 손상시키고 V (D) J J 재조합을 억제합니다.

Article

Published on 2021-10-132022-09-01
Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity affecting BRCA1 cell line clinical Clinical outcome clinical outcomes Clinical studies coronavirus coronavirus disease Coronavirus disease 2019 damage DNA DNA damage DNA damage repair DNA repair effective full-length immune immune responses Immunity impede in vitro indicated Infection influence inhibit mechanism nucleus pandemic Patient patients potential molecular Protein public health Recombination recruitment repair required respiratory SARS–CoV–2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effect significantly spike Spike protein spike-based vaccines the spike protein V(D)J recombination Vaccine
[DOI] 10.3390/v13102056 PMC 바로가기 [Article Type] Article