Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern높은 수준의 바이러스 특이적 항체가 있는 회복기 혈장은 우려되는 SARS-CoV-2 변이체를 효과적으로 중화합니다Article Published on 2022-06-282022-09-11 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody CCP convalescent plasma coronavirus correlated COVID-19 COVID-19 convalescent plasma Donor donors drug Drug administration effective effective drugs Efficacy Euroimmun Evolution examined exposure to food Food and Drug Administration high-titer CCP Hospitalization Immunoglobulin Immunoglobulin G Immunosuppressed limit Limited monoclonal antibody monoclonal antibody therapies neutralization neutralize neutralized plasma polyclonal reduce respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Therapies variant variants virus Virus neutralization [DOI] 10.1182/bloodadvances.2022007410 PMC 바로가기 [Article Type] Article
Safety and efficacy of convalescent plasma for severe COVID-19: a randomized, single blinded, parallel, controlled clinical study중증 COVID-19에 대한 회복기 혈장의 안전성 및 효능: 무작위, 단일 맹검, 병렬, 대조 임상 연구Randomized Controlled Trial Published on 2022-06-272022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI adjusted Admission anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 S1 IgG antibodies antibody antibody levels assigned benefit blinded clinical clinical study clinical trial conducted controlled clinical study convalescent plasma coronavirus disease Coronavirus disease 2019 COVID-19 CP plus standard therapy discharge dose early stage early stages Efficacy Estimated evaluate evaluated Follow-up hospital Hospitalization IgA IgA antibodies IgA antibody IgG increase in intensive care intensive care unit admission less mechanical ventilation Mortality MOST pandemic participant Patient patients per-protocol analysis plasma Primary outcome Primary outcomes Randomized receive reduce reduction reduction in S1 IgG Safe Safety SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants secondary outcome Secondary outcomes Seven severe coronavirus disease severe COVID-19 ST alone ST group Standard therapy symptoms onset the disease the SARS-CoV-2 the WHO therapeutic option titers transfused transfused plasma transfusion treat Variability variant Viral Viral load viral load reduction was obtained [DOI] 10.1186/s12879-022-07560-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 and venous thromboembolism risk in patients with sickle cell diseaseShort communication Published on 2022-06-272022-10-05 Journal: Blood advances [Category] 진단, [키워드] adjusted adjusted relative risk baseline characteristics causes Cell confidence interval COVID-19 COVID-19 infection disease group Health Hospitalization Hospitalized increase life-threatening log multisite no significant difference Patient patients hospitalized Poisson regression model Research risk risk ratio robust SCD severe COVID-19 illness Severe COVID-19 Infection Thromboembolism Venous Thromboembolism VTE VTE risk with COVID-19 [DOI] 10.1182/bloodadvances.2022007219 [Article Type] Short communication
Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England쌍둥이 봉우리: 영국의 Omicron SARS-CoV-2 BA.1 및 BA.2 전염병Article Published on 2022-06-242022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assessment Chain Reaction community transmission coronavirus deaths England Epidemics highest Hospitalization incidence rate increase in much lower nose swab nose swabs Older omicron Omicron variant participant polymerase chain polymerase chain reaction Prevalence Randomly Rapid recorded replacing reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus Transmission twin vaccination variant [DOI] 10.1126/science.abq4411 PMC 바로가기 [Article Type] Article
Effect of Cholecalciferol Supplementation on the Clinical Features and Inflammatory Markers in Hospitalized COVID-19 Patients: A Randomized, Open-Label, Single-Center Study입원한 COVID-19 환자의 임상 특징 및 염증 표지자에 대한 콜레칼시페롤 보충제의 효과: 무작위, 공개 라벨, 단일 센터 연구Randomized Controlled Trial Published on 2022-06-232022-09-11 Journal: Nutrients [Category] 바이오마커, 임상, [키워드] 25-hydroxyvitamin D 25(OH)D Affect B cell B cell subsets bolus C-reactive protein caused CD27 CD38 cholecalciferol cholecalciferol supplementation clinical clinical benefit clinical feature Clinical features Concomitant medication Course COVID-19 COVID-19 patients decrease DN B cell DN B cells dose Effect evaluate the effect frequencies Frequency group higher risk Hospitalization Immune status increase in Inflammatory Inflammatory marker inflammatory markers lymphocyte Lymphocyte count lymphocyte counts morbidity neutrophil number of bed observé Patient patients with COVID-19 Randomized receive receiving recent SARS-CoV-2 serum significant difference significant differences significantly higher significantly lower two group two groups Vitamin D Vitamin D supplementation was determined [DOI] 10.3390/nu14132602 PMC 바로가기 [Article Type] Randomized Controlled Trial
Investigation of target sequencing of SARS-CoV-2 and immunogenic GWAS profiling in host cells of COVID-19 in Vietnam베트남 코로나19 숙주 세포에서 SARS-CoV-2 표적 염기서열 분석 및 면역원성 GWAS 프로파일링Article Published on 2022-06-192022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] affected AUC Biomarker clade clinical outcomes comprehensive analysis coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity COVID-19 treatment dataset delta variant Disease progression downstream analysis Elastic forest framework global pandemic GWAS Health Healthcare system Healthcare systems high accuracy Hospitalization host cell host cells immune response immune responses immunogenic Impact investigated investigation Predictive Predictive model prevalent Previous studies previous study progression Protein provided PRS Random forest Research risk risk score SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Sequencing severity severity of COVID-19 SNP SVM the disease therapeutic target therapeutic targets Treatment Vietnam virus virus variant virus variants [DOI] 10.1186/s12879-022-07415-1 PMC 바로가기 [Article Type] Article
Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation네 가지 COVID-19 파동에 걸친 어린이의 SARS-CoV-2 변이체의 역학 특성 및 임상 발현과의 상관 관계Article Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] B.1.1.7 children circulation clade clades correlation COVID-19 defined demonstrated feature Frequency highest Hospitalization Lineage lineages Local manifestation negative correlation pandemic SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 pandemic SARS-CoV-2 positive patient SARS-CoV-2 transmission SARS-CoV-2 variant severity sustained Transmission Viral load Virological [DOI] 10.1038/s41598-022-14426-0 PMC 바로가기 [Article Type] Article
Absence of neutralizing antibodies against the Omicron SARS-CoV-2 variant in convalescent sera from individuals infected with the ancestral SARS-CoV-2 virus or its Gamma variantArticle Published on 2022-06-162022-11-15 Journal: Clinics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody convalescent sera dominant effective evaluate Gamma Gamma variant Hospitalization in vitro individual individuals Infection Mild moderate Neutralizing antibodies neutralizing antibody Neutralizing antibody response omicron Omicron variant pandemic positive Protective protective antibodies SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 virus sera serum strain Symptom the SARS-CoV-2 variant variants [DOI] 10.1016/j.clinsp.2022.100068 PMC 바로가기
SARS-CoV-2 Transmission in the Military during the Early Phase of the Pandemic-A Systematic AnalysisPandemic-A 체계적 분석 초기 단계의 군 내 SARS-CoV-2 전파Article Published on 2022-06-162022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95%CI affected Ageusia Anosmia baseline Characteristics Chinese Clinical characteristics cough country COVID-19 COVID-19 case COVID-19 cases COVID-19 incidence COVID-19 pandemic database detect early phase English epidemiological exposure Factor headache higher risk Hospitalization identify incidence incidence of cases incidence of COVID-19 Local majority military mortality rate mortality rates myalgia nasal congestion pandemic phase potential risk SARS-CoV-2 SARS-CoV-2 surveillance SARS-CoV-2 transmission screened symptomatic Symptoms Transmission [DOI] 10.3390/ijerph19127418 PMC 바로가기 [Article Type] Article
Detection of residual pulmonary alterations with lung ultrasound and effects on postoperative pulmonary complications for patients with asymptomatic SARS-CoV-2 infection undergoing surgeries수술을 받는 무증상 SARS-CoV-2 감염 환자의 폐초음파로 잔류 폐 변이 감지 및 수술 후 폐 합병증에 미치는 영향Observational Study Published on 2022-06-162022-09-11 Journal: BMC Anesthesiology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] acute respiratory syndrome Affect alteration appear approval Asymptomatic asymptomatic patient asymptomatic patients Chain Reaction Clinical course collected Committee Compliance complications consecutive patient consecutive patients coronavirus described detect detection determine distress Effect evaluate higher risk Hospital stay Hospitalization incidence Infection intensive care intensive care unit lung Lung ultrasound observational study pandemic pathological finding pathological findings Patient patients patients with asymptomatic PCR physical pleural thickening Pneumonia polymerase chain polymerase chain reaction Post-COVID-19 patients postoperative Postoperative pulmonary complications prospective observational study pulmonary compliance pulmonary complication pulmonary complications remained required SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection severe acute respiratory syndrome Coronavirus severity Static static compliance Static compliance. surgery surgical Surgical Procedure vasoactive drug vasoactive drugs was performed were recorded [DOI] 10.1186/s12871-022-01715-4 PMC 바로가기 [Article Type] Observational Study