Bilateral macular hemorrhage in a patient with COVID-19Case Report Published on 2020-10-092022-10-27 Journal: American Journal of Ophthalmology Case Reports [Category] COVID-19, [키워드] acute respiratory syndrome Bilateral blood test coronavirus demonstrated endothelial hemolytic anemia hemorrhage Hereditary spherocytosis Importance Macular hemorrhage observation oxygen Pathogenesis Patient patient with COVID-19 Peripheral blood SARS-CoV-2 syndrome triggered [DOI] 10.1016/j.ajoc.2020.100958 PMC 바로가기 [Article Type] Case Report
Two distinct immunopathological profiles in autopsy lungs of COVID-19Article Published on 2020-10-082022-10-04 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] activated acute respiratory syndrome Autopsy Biomarker caused CD8 cellular characterized coronavirus COVID-19 COVID-19 patient Cytokines damaged differential expression Disease progression expression feature highlight histologic Hospitalization immune response Immunopathogenesis immunopathological Infection infiltrating interferon ISG ISGs Local lung lung damage Lung disease lung tissue Lungs macrophages Mortality normal lung tissue pathogenic Patient patients Peripheral blood profile progression pulmonary damage reaction pattern Respiratory disease SARS-CoV-2 SARS-COV-2 infection Sequencing significantly Stage stimulated T cell tissue transcriptomic Treatment viral infection Viral load viral loads worldwide pandemic [DOI] 10.1038/s41467-020-18854-2 PMC 바로가기 [Article Type] Article
Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patientsCOVID-19 환자의 말초혈액 T 림프구에서 CD95(Fas) 및 PD-1 발현 증가Article Published on 2020-10-012022-08-31 Journal: British Journal of Haematology [Category] MERS, SARS, 바이오마커, [키워드] activated T cells Apoptosis CD4 CD8 CD95 (Fas) Cell controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection COVID-19 patient events Exhaustion expressing expression FAS flow cytometry hallmark Increased Laboratory laboratory finding lymphocyte Lymphocytes molecules PD-1 Peripheral blood shift significantly higher T cell T cells T lymphocyte [DOI] 10.1111/bjh.17034 PMC 바로가기 [Article Type] Article
Molecular Alterations Prompted by SARS-CoV-2 Infection: Induction of Hyaluronan, Glycosaminoglycan and Mucopolysaccharide MetabolismSARS-CoV-2 감염으로 인한 분자 변화: 히알루로난, 글리코사미노글리칸 및 뮤코다당류 대사 유도Meta-Analysis Published on 2020-10-012022-09-12 Journal: Archives of medical research [Category] MERS, SARS, 진단, [키워드] acute respiratory distress alteration Asymptomatic Atypical Blood bronchoalveolar Bronchoalveolar transcriptome CD4+ Cell cellular characteristic Chest common cold component Computerized tomography COVID-19 death develop etiological agent exacerbated glycosaminoglycan ground-glass opacity Hyaluronan identify Immune cell immune response increase in induction Infection involved lung infiltration macrophages majority mechanical ventilation metabolism Mild moderate molecular Monocytes mononuclear cell Mucopolysaccharide multiple organ failure Neutrophils Pathogenesis pathogenesis of COVID-19 Patient patients performed Peripheral blood Pneumonia profiles proliferative reduction RNAseq SARS-CoV-2 subset Symptom syndrome T lymphocytes the SARS-CoV-2 [DOI] 10.1016/j.arcmed.2020.06.011 PMC 바로가기 [Article Type] Meta-Analysis
IL-6–based mortality risk model for hospitalized patients with COVID-19Research article Published on 2020-10-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, [키워드] age albumin Analysis Biomarker Biomarkers C-reactive protein can be used clinical decision Clinical deterioration contributed Coronavirus disease 2019 COVID-19 Cutoff develop diagnosed died discharged distress ferritin fraction global pandemic high accuracy hospital Hospitalization hospitalized patient IL-6 IMPROVE initial lactate dehydrogenase LDH Lymphocyte count monocyte Mortality mortality risk mortality risk model multivariable neutrophil count Neutrophil-to-lymphocyte ratio nonsurvivor objective outcome oxygen oxygen saturation Patient patients with COVID-19 Peripheral blood predict Predictive Predictive model prospective cohort Result risk risk stratification sensitivity severity Spain specificity SpO2/FiO2 survivor the disease with COVID-19 [DOI] 10.1016/j.jaci.2020.07.009 [Article Type] Research article
Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a studyHIV에 감염되지 않은 건강한 성인을 대상으로 한 두 가지 이종 HIV 백신 요법의 안전성 및 면역원성(TRAVERSE): 무작위 배정, 병렬 그룹, 위약 대조, 이중 맹검, 1/2a상 연구Articles Published on 2020-09-302022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI Ad26 Adenovirus Administered advancement adverse event adverse events aligned All participant All participants Analysis Antigen antigens applied assigned binding antibodies binding antibody blood sample breadth CD4+ T-cell clade collected computer-generated Defense Deltoid muscle Department diagnosed dose double-blind Efficacy elicit Eligible participants ELISpot responses enrolled finding first vaccination foundation funding group groups healthy Heterologous HIV HIV infection HIV vaccine HIV-1 infection HIV-uninfected IFNγ ELISPOT response IFNγ ELISPOT responses IgG immune response immune responses Immunity immunogenicity injection Intramuscular injection investigator investigators Jackson janssen Laboratory Local magnitude median medical history Medicine Melinda Gate Melinda Gates Military Medicine mononuclear cell mononuclear cells opinion Other parallel-group participant PBMC PBMCs per protocol per-protocol Peripheral blood Peripheral blood mononuclear cells Physical examination Placebo placebo group placebo-controlled placebos prevention randomisation randomised Randomly randomly permuted block randomly permuted blocks regimen regimens Registered repeated risk Safe Safety second vaccination Sponsor stratified subgroups systemic reactogenicity T-cell Response tested tetravalent the placebo group titre titres Tolerability treatment allocation Trial trivalent USA vaccination vaccination schedule Vaccinations Vaccine vaccine group vectored vaccine vital sign was done with HIV [DOI] 10.1016/S2352-3018(20)30229-0 PMC 바로가기 [Article Type] Articles
Suboptimal SARS-CoV-2−specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotype530 Published on 2020-09-292022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] Activation acute respiratory syndrome CD38 CD4 CD8 CD8+ T cells Cell Cell-mediated immunity central memory circulating classical Clinical severity comparable convalescent convalescent COVID-19 patient coronavirus COVID-19 COVID-19 convalescent patient COVID-19 patients diminishe Donor effector memory ENhance Epstein–Barr virus Ex vivo example experience expressed Frequency HLA type HLA-A*02:01 HLA-DR Immunity in vitro indicated Infection Influenza investigated majority memory mononuclear cell naïve overlapping patients peptide Peripheral blood phenotype Phenotypes Phenotyping Population populations Prevalence priming promote recall Reinfection robust SARS-CoV-2 SARS-CoV-2 epitopes SARS-COV-2 infection Significance Stimulating T cell T cell activation T cell epitopes T cell memory T cells therapeutic uninfected Vaccine [DOI] 10.1073/pnas.2015486117 PMC 바로가기 [Article Type] 530
Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic IndividualsResearch Article Published on 2020-09-292022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS, [키워드] abnormal increase acute respiratory syndrome Affect bead C reactive protein caused CD16 CD19 CD3 CD4 CD56 CD8 Clinical severity Comorbidity complement conducted confirmed case coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical CRP cytokine Data analysis decrease demonstrated disease severity effort eligible flow cytometric Frequency global pandemic IFN IgA IgE IgG IgM IL-10 IL-2 IL-4 IL-6 immune system Immunity immunoassay Immunoglobulin Immunologic immunological characteristics immunological parameters Immunological response in both group individual Level lymphocyte subpopulation NDM neutrophil count NK cell no significant difference participant Peripheral blood pilot study proportion Result retrospective risk factor SARS-CoV-2 Sex significantly higher surface marker T2D Th1 cytokine TNF- α two groups Type type 2 diabete virus [DOI] 10.1155/2020/6914878 PMC 바로가기 [Article Type] Research Article
S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 SubunitResearch Article Published on 2020-09-252022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] accompanied acute respiratory syndrome Analysis analyzed anti-N IgG anti-S2 antibody antibody production asked B cell B cell response circulating conserved convalescent coronavirus coronavirus disease correlated strongly COVID-19 cross-reactive disease ENhance frequencies generate healthy donor Human human coronavirus OC43 IgG IgG antibodies IgG level IgG titer immune memory immune protection Immunity individuals Infection MBC memory B cell memory B cells mononuclear cell MOST non-SARS-CoV-2 protein nucleocapsid pandemic PBMCs Peripheral blood Population Postinfection Production Protein provide RBD reactive Receptor binding domain reflect Reinfection S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera specificity Spike protein Spread subject subjects susceptibility susceptible the RBD the S protein the SARS-CoV-2 virus Virus-specific IgG [DOI] 10.1128/mBio.01991-20 PMC 바로가기 [Article Type] Research Article
Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and HydroxychloroquineReview Article Published on 2020-09-252022-10-29 Journal: Journal of Immunology Research [Category] Coronavirus, MERS, SARS, [키워드] Affect arachidonic acid B-cell block Cell Compound COVID-19 cytokine storm critically ill patients cytokine cytokine production deplete derivative exhibit Extracellular Glucose HCQ Hydroxychloroquine IFN IgG IgM IL-10 IL-17 IL-2 IL-22 IL-6 inhibit inhibiting inhibitor interferon kinase memory B-cell mononuclear cell Patient PBMCs Peripheral blood PGs plasmablast Potential producing reactive oxygen species Safe secretion Side effect stability Th2 cytokine the patient Trigger triggered [DOI] 10.1155/2020/4582612 PMC 바로가기 [Article Type] Review Article