SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’SARS-CoV-2 항체 역학 및 이탈리아 Vo' 시에서 지역사회 전체 혈청 검사에서 전파Article Published on 2021-07-192022-09-10 Journal: Nature Communications [Category] SARS, 진단, 치료법, [키워드] 95% CI 95% confidence interval Analysis antibody chain Chain Reaction Computational models conducted confidence Contact tracing credible interval Epidemic Epidemiology Follow-up indicate interval Italian Italy neutralisation neutralisation assay nucleocapsid antigens pandemic PCR polymerase chain reaction positive reaction reactivity SARS-CoV-2 SARS-CoV-2 antibody sera Serological assay serological survey Serological surveys Serological testing Seroprevalence serostatus Swab tested Transmission unique viral infection [DOI] 10.1038/s41467-021-24622-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assayResearch Paper Published on 2021-07-182022-10-28 Journal: One Health [Category] COVID-19, [키워드] absence anti-SARS-CoV-2 antibodies assays automated canine Clinical signs Coronaviruses correlation COVID-19 cross-reactivity diagnosis of SARS-CoV-2 dog ELISA epidemiological surveillance Epidemiosurveillance experimental model France genomic data healthy Hypothesis incidence multiple mutation one health pandemic performed populations positive Region SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 seroprevalence sera serological test serology significant difference significantly higher Surveillance susceptibility susceptible variant Viral transmission [DOI] 10.1016/j.onehlt.2021.100293 PMC 바로가기 [Article Type] Research Paper
Th2/Th1 Cytokine Imbalance Is Associated With Higher COVID-19 Risk MortalityTh2/Th1 사이토 카인 불균형은 더 높은 Covid-19 위험 사망률과 관련이 있습니다.Genetics Published on 2021-07-162022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 expression addition Admission Affect age airway Analysis analyzed approach Asthma asthma patient asthma patients asthmatic CD4 COVID-19 COVID-19 severe respiratory syndrome cytokine death Deceased determined by died enrichment score evaluated Gene Expression healthy healthy controls Hospital admission hospitalized patient hospitalized patients Imbalance immune response Linear regression male Mortality Mount Sinai Mount Sinai Health System multi-organ inflammatory response nasal epithelium non-infected Older age outcome Patient patient reported patients patients hospitalized phenotype positive predict proteomics respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV2 infection sera serum serum proteomics severe respiratory syndrome Sex significantly smoker Smokers smoking smoking status sputum suggested System T cell T cells T-cells Th1 Th1 pathway Th17 Th2 Th2 pathway the SARS-CoV-2 virus those that survived type 2 helper Variation [DOI] 10.3389/fgene.2021.706902 PMC 바로가기 [Article Type] Genetics
A Combination of N and S Antigens With IgA and IgG Measurement Strengthens the Accuracy of SARS-CoV-2 SerodiagnosticsN 및 S 항원과 IgA 및 IgG 측정의 조합으로 SARS-CoV-2 혈청 진단의 정확성 강화Major Articles and Brief Reports Published on 2021-07-152022-09-10 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법, [키워드] 229E acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis antibodies antibody Antigen antigens Combination convalescent phase coronavirus coronavirus proteins correlation COVID-19 COVID-19 patient COVID-19 patients CoVs diagnostics enzyme enzyme immunoassay enzyme immunoassays estimates human CoVs humoral immune response humoral immune responses Humoral immunity IgA IgG IgM immune response immune responses immunoassay Immunoglobulin in viral increase Infection measurement MERS Microneutralization test Middle East Middle East respiratory syndrome N protein N proteins Nasopharyngeal swab Nasopharyngeal swab samples Neutralizing antibodies NL63 primary diagnosis provide RBD Receptor binding domain respiratory respiratory infection Result S antigen SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 S1 sensitivity sera serological serology Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly increased Spike protein syndrome test results Viral viral spike protein virus RNA were used [DOI] 10.1093/infdis/jiab222 PMC 바로가기 [Article Type] Major Articles and Brief Reports
Mild COVID-19 despite autoantibodies against type I IFNs in autoimmune polyendocrine syndrome type 1자가 면역 다 내분비 증후군 유형 1에서 유형 I IFN에 대한 자가 항체에도 불구하고 경미한 COVID-19Case Reports Published on 2021-07-152022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, [키워드] age AIRE assays autoantibody Autoimmune biallelic caused clinical Complete COVID-19 Deleterious dominant Dyspnea female General population heterozygous high temperature IFN-α Immunity immunology infected patient Innate Innate immunity Mild symptom Mutation Neutralizing Oxygen requirement Patient Phosphorylation prospectively studied reported SARS-CoV-2 sera severe COVID-19 Stat1 subject syndrome tested the patient Transcription Type I IFN type I IFNs [DOI] 10.1172/JCI150867 PMC 바로가기 [Article Type] Case Reports
Dynamic Assay for Profiling Anti-SARS-CoV-2 Antibodies and Their ACE2/Spike RBD Neutralization Capacity항 -SARS-COV-2 항체 프로파일 링에 대한 동적 분석 및 ACE2/스파이크 RBD 중화 능력Article Published on 2021-07-152022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] a minor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed antibody Antibody Response Antibody responses approved Capacity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dynamic enzyme-linked immunosorbent enzyme-linked immunosorbent assay groups inaccessible include isotypes Local Medicine minor Modification Mount Sinai neutralization Neutralization assay neutralization capacity New York pandemic patient sera populations Profiling protocol pseudovirus infection pseudovirus infection model RBD replicated Research respiratory SARS-CoV-2 SARS-CoV-2 antibody School sera Seroconversion serological serological assays serology serology assay severe acute respiratory syndrome Coronavirus subset [DOI] 10.3390/v13071371 PMC 바로가기 [Article Type] Article
Neutralising SARS-CoV-2 RBD-specific antibodies persist for at least six months independently of symptoms in adults Research Published on 2021-07-142022-10-05 Journal: Communications Medicine [Category] 진단, [키워드] acute respiratory syndrome All participant analysed Anosmia antibodies antibody antibody reactivity coronavirus detect detectable domain Europe evaluated IgA antibody IgG Immunoglobulin independent Large-scale testing neutralisation test neutralising antibody nucleocapsid protein pandemic Participants positive Post-infection RBD RBD-specific antibody reactive Result S1-reactive antibody SARS-CoV-2 SARS-CoV-2 RBD-specific antibody SARS-CoV-2-specific antibody sera Symptom Symptoms the S1 protein the S1 subunit the spike protein Virus neutralisation [DOI] 10.1038/s43856-021-00012-4 [Article Type] Research
Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteinsSARS-CoV-2에 대한 항체 환경은 비구조적/부속적 및 구조적 단백질 간의 상당한 차이를 보여줍니다Article Published on 2021-07-132022-09-12 Journal: Cell Reports [Category] MERS, SARS, 진단, [키워드] accessory protein accessory proteins Antibody Response Clinical outcome COVID-19 COVID-19 sera death decrease disease severity elicit facilitate humoral Humoral immunity IgG IgG antibody IgG response IgG responses IgM immune immune response Immunoglobulin immunology Microarray N protein N proteins non-structural protein non-structural/accessory proteins Non-survivors nsp1 Nsp7 NSP8 ORF3b Orf9b prevalent Protein proteome proteome microarray. RdRP reveal SARS-CoV-2 sera significant difference structural protein symptom onset the SARS-CoV-2 [DOI] 10.1016/j.celrep.2021.109391 PMC 바로가기 [Article Type] Article
Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 VariantsArticle Published on 2021-07-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activity antibodies approved B.1.1.7 B.1.351 B.1.617 B.1.617.2 circulating concern country COVID-19 decrease domain Efficacy Endemic epidemiological Genetic Genotype Lineage Local Mutation neutralization Neutralizing activity neutralizing effect no significant difference P.1 RBD RBD mutations reduction reported S477N SARS-CoV-2 sera Sputnik V statistically significant the RBD Transmissibility vaccination Vaccine Vaccines variant variants of concern virus virus neutralizing activity VoC [DOI] 10.3390/vaccines9070779 PMC 바로가기 [Article Type] Article
The investigation of mRNA vaccines formulated in liposomes administrated in multiple routes against SARS-CoV-2SARS-CoV-2에 대한 다중 경로로 투여되는 리포솜에 제형화된 mRNA 백신의 조사Article Published on 2021-07-102022-09-12 Journal: Journal of controlled release : official journal o [Category] SARS, 진단, [키워드] administration Administration route Affect cellular immune responses COVID-19 Efficacy and safety Express global public health immunized mice in vivo indicated Intramuscular injection investigated Lipid nanoparticle Liposome liposomes LNP mice mRNA mRNA vaccine mRNA vaccines neutralized neutralizing capacity pandemic Prevent public health crisis RBD Receptor-binding domain safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudotyped virus SARS-CoV-2 RBD SARS-CoV-2 vaccine sera specific antibody Th2-type Vaccine virus [DOI] 10.1016/j.jconrel.2021.05.024 PMC 바로가기 [Article Type] Article