Impact of close interpersonal contact on COVID-19 incidence: Evidence from 1 year of mobile device dataResearch Article Published on 2022-01-072022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] cause Connecticut Contact coronavirus disease COVID-19 COVID-19 case COVID-19 transmission description event explain Frequency help Impact Infection initial local outbreak Metrics population level predicted quantified resource social distancing Transmission model transmission of SARS-CoV-2 virus [DOI] 10.1126/sciadv.abi5499 PMC 바로가기 [Article Type] Research Article
Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins30229 SARS-CoV-2 균주의 상위 10개 동의어가 아닌 변이체가 단백질에 미치는 영향 예측Article Published on 2022-01-062022-09-11 Journal: F1000Research [Category] SARS, 변종, [키워드] addition affecting Amino acid amino acid residue Analysis analyzed bioinformatics cause co-mutation computational studies Computational study consequence COVID-19 D614G Deleterious Effect Frequency functions highest Impact in vitro in vivo Multiple studies Mutation N protein N501Y nine nonsynonymous mutation nonsynonymous mutation. Nonsynonymous mutations nonsynonymous variant Nsp12 nsp5 ORF1 ORF1a ORF1b ORF3 ORF3a outbreak P323L pathogen prediction Protein protein structure Proteins Q57H reported S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequences SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strain SARS-CoV-2 virus stability Structure the SARS-CoV-2 genome wild type Wuhan Wuhan, China [DOI] 10.12688/f1000research.72904.2 PMC 바로가기 [Article Type] Article
Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19: a randomised double-blinded placebo-controlled trialRandomized Controlled Trial Published on 2022-01-062022-10-05 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 임상, [키워드] acute respiratory syndrome airway antibiotic antiviral properties Azithromycin cause Combination control group coronavirus coronavirus disease COVID-19 criteria days alive death discharged double-blind double-blinded enrolment hospital hospitalisation hospitalised hospitalised patient Hydroxychloroquine immunomodulatory effects IMPROVE in vitro induce intensive care interim analysis interquartile range Intervention intervention group median monitoring board multicentre nine occurred outcome Patient patients patients receiving placebo patients with COVID-19 Placebo placebo-controlled trial positive Primary outcome randomisation randomised recruited reverse transcription PCR SARS-CoV-2 survival the placebo group Trial [DOI] 10.1183/13993003.00752-2021 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19—A Trigger Factor for Severe Immune-Mediated Thrombocytopenia in Active Rheumatoid ArthritisArticle Published on 2022-01-062022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] abnormality Adults antigen expression association autoantibody Autoimmune disease cause COVID-19 COVID-19 pandemic defined differential diagnoses epitope etiological Factor form hematological Immune complexes immune system Immune thrombocytopenic purpura incidence include individual Infection less lymphopenia Mild molecular Mortality pathology Platelet poor prognosis Rheumatoid rheumatoid arthritis risk factor SARS-CoV-2 SARS-COV-2 infection severity stimulate the SARS-CoV-2 therapeutic thrombocytopenia Trigger Variability viral infection [DOI] 10.3390/life12010077 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy ImpairmentMicrobiology Published on 2022-01-062022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome binding cause caused cells co-immunoprecipitation Coronavirus-2 Critical cross cyclosporin A Defense dsRNA early stage energy metabolism expression fluorescent homeostasis host cell increase in inhibited initiated innate immune response Interaction involved knockdown Microscopy Mitochondria mitochondrial mitochondrial accumulation mitochondrial dysfunction mitochondrial membrane mitophagy performed Proteins Quality control reactive oxygen specy recruitment reduced RNA ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selective substrate Tom20 Viral load viral RNA localization virus clearance [DOI] 10.3389/fmicb.2021.780768 PMC 바로가기 [Article Type] Microbiology
Molecular Modeling and Preliminary Clinical Data Suggesting Antiviral Activity for Chlorpheniramine (Chlorphenamine) Against COVID-19Infectious Disease Published on 2022-01-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] activity acute respiratory syndrome Against antiviral activity Antiviral agents cause Chlorphenamine Chlorpheniramine chlorpheniramine maleate clinical clinical evidence Clinical findings coronavirus disease Coronavirus-2 COVID-19 include indicate modeling Molecular modeling SARS-CoV-2 similarity Structure Support the Betacoronavirus [DOI] 10.7759/cureus.20980 PMC 바로가기 [Article Type] Infectious Disease
Dry heat sterilization as a method to recycle N95 respirator masks: The importance of fitResearch Article Published on 2022-01-052022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] cause change Complete Contact COVID-19 pandemic dry heat Efficacy evaluated filtration highlight inactivation Microscopy N95 respirator N95 respirators Quantitative Raman spectroscopy Respirator reuse SARS-CoV-2 Treatment while X-ray diffraction X-ray spectroscopy [DOI] 10.1371/journal.pone.0257963 PMC 바로가기 [Article Type] Research Article
COVID-19 and Air Pollution: A Spatial Analysis of Particulate Matter Concentration and Pandemic-Associated Mortality in the USArticle Published on 2022-01-052022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Air pollution Analysis Antiviral treatment association cause China Clustering combating Concentration conducted confounding variable COVID-19 COVID-19 case COVID-19 mortality death Efficacy exacerbated exhibited Health individual Intervention Italy matter Mortality Novel coronavirus pandemic Particulate PM positive correlation reported Research Result SARS-CoV-2 similar study social determinant Spatial analysis the disease The United States Vaccine virus with COVID-19 Wuhan, China [DOI] 10.3390/ijerph19010592 PMC 바로가기 [Article Type] Article
Enhancing Australian Mortality Data to Meet Future Health Information DemandsBrief Report Published on 2022-01-052022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] assist automated cause cause of death Certificate coding coronial investigation COVID-19 pandemic dataset Demand Enhancing Evolution Future Health Mortality mortality data pandemic Research Support virus [DOI] 10.3390/ijerph19010603 PMC 바로가기 [Article Type] Brief Report
An Assessment of the Impact of SARS-CoV-2 on a Level 1 Trauma Center Including Subgroup Analysis of Orthopedic Injuries and Mechanism of InjuryOrthopedics Published on 2022-01-052022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Admission Admissions affected assessment association auto Care cause center change Community conducted coronavirus disease correlated COVID COVID-19 COVID-19 pandemic cut down decrease demographics detectable distribution Effect Epidemiology expected Factor Fracture Healthcare system hospital Impact Including increase in information Injury level 1 lockdown material mechanism mechanisms operative orthopedic Orthopedics pandemic Patient pediatric performed provided registry Research resource Result retrospective SARS-CoV-2 significant difference surgery surgical trauma trauma patients virus were recorded [DOI] 10.7759/cureus.20954 PMC 바로가기 [Article Type] Orthopedics