The ROMANOV study found impaired humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in virus-unexposed patients receiving maintenance hemodialysisROMANOV 연구는 유지 혈액투석을 받고 있는 바이러스에 노출되지 않은 환자에서 SARS-CoV-2 mRNA 백신에 대한 손상된 체액 및 세포 면역 반응을 발견했습니다Article Published on 2021-10-012022-09-12 Journal: Kidney international [Category] MERS, SARS, 진단, [키워드] absence Analysis Anti-RBD IgG Anti-spike benefit BNT162b2 CD4 CD8 Cell Cellular immune response circulation Complete correlated COVID-19 COVID-19 in patient death dose effector generate healthy volunteer healthy volunteers Hemodialysis high risk humoral IgG immune immune response immune responses immunosuppressive Infection injection interferon less mRNA vaccine mRNA vaccines naïve of BNT162b2 Patient RBD receiving Receptor binding domain SARS-CoV-2 SARS-CoV-2 virus significantly T cell T cells therapy vaccination Vaccine vaccine injection virus weakened were excluded were measured [DOI] 10.1016/j.kint.2021.07.005 PMC 바로가기 [Article Type] Article
Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression면역 억제를 받는 환자에서 SARS-CoV-2 백신 접종에 대한 체액 및 T 세포 반응Article Published on 2021-10-012022-09-11 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody Response assays Autoimmune Autoimmune diseases B-cell B-lymphocytes BNT162b2 BNT162b2 mRNA ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccines Combination COVID-19 detectable Diseases Efficacy Evidence evidence of failure glomerular glomerular diseases healthy individuals immune responses immunogenic immunogenicity Immunological response Immunosuppression immunosuppressive immunosuppressive therapies immunosuppressive therapy impair induce investigated Lymphocytes mounted non-responder participant Patient preserved receiving responders response responses rituximab robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion seroconvert seroconverted serological serology T-cell ELISpot T-cell Response T-cell responses tacrolimus therapy vaccination Vaccine vaccine dose Vaccines were used [DOI] 10.1136/annrheumdis-2021-220626 PMC 바로가기 [Article Type] Article
Current scenario of COVID-19 vaccinations and immune response along with antibody titer in vaccinated inhabitants of different countries다른 국가의 예방 접종을받은 주민의 항체 역가와 함께 COVID-19 예방 접종 및 면역 반응의 현재 시나리오Review Published on 2021-10-012022-09-11 Journal: International immunopharmacology [Category] SARS, 변종, [키워드] Adaptive immunity addition addressed Antibody titer approach cellular Cellular and humoral responses cellular immunity Clinical management clinical trial Combination country COVID-19 COVID-19 pandemic COVID-19 vaccination Critical current generate Humoral response immune immune response immune responses Immunity inactivated induce Infection long-lasting neutralization Neutralizing antibodies nucleic acid overcome pathogenicity peptide phase 4 Population proportion response rising Safe Safety assessment SARS-CoV-2 SARS-CoV-2 variants Spread Trial vaccination Vaccine vaccine candidates Vaccine development Vaccine-induced immunity Vaccines variant variants variants of SARS-CoV-2 virus virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1016/j.intimp.2021.108050 PMC 바로가기 [Article Type] Review
SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity리툭시맙 치료 환자에서 SARS-CoV-2 백신 접종: T 세포 매개 면역이 있는 경우 B 세포가 체액성 면역 반응을 촉진합니다Article Published on 2021-10-012022-09-11 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] Affect antibody assays B cell B cells BNT162b2 CD19 controls correlated COVID-19 detectable develop Elecsy enzyme enzyme-linked immunosorbent except for healthy control healthy individual healthy individuals humoral humoral immune response humoral immune responses IFN-γ immune response immune responses immunisation immunoassay independent independent of induce levels of antibody mounted mRNA mRNA-1273 n=36 neutralisation neutralisation tests Neutralising Antibodies neutralising antibody one patient Patient patients peripheral B cell peripheral B cells promote protective effect Protective effects quantified RBD Receptor-binding domain responses rituximab RTX SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccination SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells SARS-CoV-2-specific T-cell response SARS-CoV-2-specific T-cell responses seroconverted significantly specific antibodies Spike protein T cells T-cell responses T-cell-mediated immunity the patient the receptor-binding domain the SARS-CoV-2 the spike protein therapy Treatment vaccination [DOI] 10.1136/annrheumdis-2021-220781 PMC 바로가기 [Article Type] Article
Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective RoleCOVID-19에서 메트포르민의 치료 가능성: 보호 역할에 대한 추론Review Published on 2021-10-012022-09-11 Journal: Trends in microbiology [Category] SARS, 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus attenuate blood glucose blood glucose control cardiovascular disease Clinical outcome Comorbidities Comorbidity complications coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection COVID-19 infections COVID-19 patients diabetes Diabetic diabetic patient diabetic patients disease severity endothelial Endothelial dysfunction endothelial function Glucose glucose control Hospitalization hyperglycemia hypertension immune response immune responses Infection Inflammatory inhibit intensive care medication metformin modify Mortality obesity patients Potential Prognosis Reasoning role SARS-CoV-2 SARS-CoV-2 infections Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe metabolic thrombotic thrombotic event Thrombotic events viral entry while [DOI] 10.1016/j.tim.2021.03.004 PMC 바로가기 [Article Type] Review
The urgent need for more basic research on SARS-Cov2 infection and vaccines in assessing potential psychoneurological effects using maternal immune activation (MIA) and other preclinical modeling모성 면역 활성화(MIA) 및 기타 전임상 모델링을 사용하여 잠재적인 정신 신경학적 효과를 평가하기 위한 SARS-Cov2 감염 및 백신에 대한 보다 기초적인 연구가 시급합니다.Review Published on 2021-10-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 변종, [키워드] accumulates aging allergy Autoimmunity Behavior Clinical data during pregnancy Effect Efficacy expression foster General population heterogeneity human ACE2 receptor immune activation immune response immune responses incorporation Infection likelihood Maternal Maternal Immune Activation MIA mutants neurologic obesity pandemic Preclinical Preclinical Testing Pregnancy progeny receptor Research responses SARS-CoV2 Stage supported target tissue TLR Transgenic mouse Vaccine vaccine candidate vaccine candidates Vaccines variable [DOI] 10.1016/j.bbi.2021.06.009 PMC 바로가기 [Article Type] Review
Regulatory T cells in COVID-19Commentary Published on 2021-10-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] acute respiratory syndrome Affect alleviate caused coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated disease Disease progression exacerbated highlight immune response immune responses immune system immunosuppressive effects Infection Inflammation Inflammatory multiple organ dysfunction outbreak Perspective prevalent recent recent finding reduced reduction Regulation Regulatory T cell regulatory T cells Respiratory failure risk SARS-CoV-2 significantly subpopulation Symptom syndrome T cell therapy Treg Tregs [DOI] 10.14336/AD.2021.0709 PMC 바로가기 [Article Type] Commentary
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19말초 혈액 세포의 단일 세포 전사체는 COVID-19의 심각성을 나타내고 설명합니다.Article Published on 2021-10-012022-09-11 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] accumulated activities addition Blood CD8 Cell cell interaction cell interactions cellular cellular and molecular Characteristics conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases critical COVID-19 patients cytokine Cytokines cytotoxicity declined discrepancy disease severity effector T cell exhibited healthy donors heterogeneous immune Immune cell immune function immune functions immune response immune responses immune system infected patient Inflammatory cytokine Inflammatory cytokines moderate monocyte Monocytes mononuclear cell natural killer pathogenic mechanisms patients PBMCs Peripheral blood peripheral blood cell Peripheral blood mononuclear cells proliferative quantity reduced regulatory network severity severity of COVID-19 significantly single-cell RNA-seq single-cell transcriptome single-cell transcriptomes stages T cells T/NK cell transcription factor transcriptional Transcriptome Treatment Variation variations weakened with COVID-19 [DOI] 10.1007/s11427-020-1880-y PMC 바로가기 [Article Type] Article
Animal models of SARS-CoV-2 transmissionSARS-CoV-2 전염 동물 모델Review Published on 2021-10-012022-09-11 Journal: Current opinion in virology [Category] SARS, 변종, [키워드] animal animal model animal models China COVID-19 pandemic high morbidity and mortality Human immune responses less morbidity and mortality preventing disease Prophylactic SARS-CoV-2 SARS-CoV-2 transmission Spread therapeutic option Transmission Vaccine virus virus variant virus variants zoonotic [DOI] 10.1016/j.coviro.2021.06.007 PMC 바로가기 [Article Type] Review
Unmethylated CpG motif-containing genomic DNA fragments of bacillus calmette-guerin improves immune response towards a DNA vaccine for COVID-19메틸화되지 않은 CpG 모티브를 함유한 바실러스 칼멧-게린의 게놈 DNA 단편은 COVID-19에 대한 DNA 백신에 대한 면역 반응을 향상시킵니다Article Published on 2021-10-012022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus addition adjuvant Antibody titers B.1.1.7 Bacillus Calmette-Guérin BALB/c mice BC01 adjuvant caused Cellular immune response coronavirus coronavirus disease coronavirus- COVID-19 CpG disease DNA DNA fragment DNA vaccine effective elicit expressing Genome Genomic DNA humoral immune response immune responses IMPROVE mice neutralize neutralizing antibody Neutralizing antibody titer neutralizing antibody titers pandemic produced respiratory SARS-CoV-2 SARS-CoV-2 spike protein sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein tested the SARS-CoV-2 unmethylated Vaccine vaccine candidate variants [DOI] 10.1016/j.vaccine.2021.08.103 PMC 바로가기 [Article Type] Article