Animal models of SARS-CoV-2 transmissionSARS-CoV-2 전염 동물 모델Review Published on 2021-10-012022-09-11 Journal: Current opinion in virology [Category] SARS, 변종, [키워드] animal animal model animal models China COVID-19 pandemic high morbidity and mortality Human immune responses less morbidity and mortality preventing disease Prophylactic SARS-CoV-2 SARS-CoV-2 transmission Spread therapeutic option Transmission Vaccine virus virus variant virus variants zoonotic [DOI] 10.1016/j.coviro.2021.06.007 PMC 바로가기 [Article Type] Review
Unmethylated CpG motif-containing genomic DNA fragments of bacillus calmette-guerin improves immune response towards a DNA vaccine for COVID-19메틸화되지 않은 CpG 모티브를 함유한 바실러스 칼멧-게린의 게놈 DNA 단편은 COVID-19에 대한 DNA 백신에 대한 면역 반응을 향상시킵니다Article Published on 2021-10-012022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus addition adjuvant Antibody titers B.1.1.7 Bacillus Calmette-Guérin BALB/c mice BC01 adjuvant caused Cellular immune response coronavirus coronavirus disease coronavirus- COVID-19 CpG disease DNA DNA fragment DNA vaccine effective elicit expressing Genome Genomic DNA humoral immune response immune responses IMPROVE mice neutralize neutralizing antibody Neutralizing antibody titer neutralizing antibody titers pandemic produced respiratory SARS-CoV-2 SARS-CoV-2 spike protein sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein tested the SARS-CoV-2 unmethylated Vaccine vaccine candidate variants [DOI] 10.1016/j.vaccine.2021.08.103 PMC 바로가기 [Article Type] Article
Host genetic factors determining COVID-19 susceptibility and severityCOVID-19 감수성과 중증도를 결정하는 숙주 유전적 요인Review Published on 2021-10-012022-09-11 Journal: EBioMedicine [Category] 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS association Asymptomatic BMI candidate candidate gene Candidate genes caused Comorbidities Course COVID-19 COVID-19 pandemic COVID-19 susceptibility death disease severity Ethnicity Factor Genetic predisposition Genetic variant genetic variants Host genetic factor host genetics immune response immune responses Immunity include increasingly Inflammation investigated Male sex Multiorgan Older age Pathogenesis performed Precision rare variant Research respiratory respiratory distress risk Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severity susceptibility syndrome therapy whole genome [DOI] 10.1016/j.ebiom.2021.103629 PMC 바로가기 [Article Type] Review
Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19SARS 코로나바이러스 2 파파인 유사 프로테아제와 면역 체계 간의 상호 작용: COVID-19 치료를 위한 잠재적 약물 표적Review Published on 2021-10-012022-09-11 Journal: Scandinavian journal of immunology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 complex complex system Compound coronavirus CoV COVID-19 CoVs cytokine production DeISGylating deubiquitinating drug drug target DUB dysregulation Effect enzyme evade Host host immunity immune immune response immune responses immune system infections inhibit inhibitor Innate innate immune responses MAPK Mild mild to moderate moderate molecules multifunctional New coronavirus NF-κB Papain Papain-like protease pathway Pathways PLPro protease public health regulate Respiratory tract infections respiratory virus respiratory viruses SARS Coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 STING suppress TGF-β Treatment treatment of COVID-19 upper respiratory tract upper respiratory tract infections viral spread viruses [DOI] 10.1111/sji.13044 PMC 바로가기 [Article Type] Review
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responsesSARS-COV-2 특이 적 T 세포 반응을 결정하기위한 진단 도구로서 플루오 스팟 분석의 평가Research Article Published on 2021-09-302022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] addition Affect aligning Amino acid appear assays blood sample Blood samples calculated cellular Cellular immune response cellular immune responses cellular response Chain Reaction Cohort COVID-19 patients cross-reactive determine diagnostic diagnostic value dual endemic HCoVs evaluated HCoVs HCW healthcare worker Healthcare workers hospitalized COVID-19 patient house human coronavirus human coronaviruses IFN-γ IgG immune response immune responses individuals less nucleocapsid Numerous peptide peptide pool peptide pools polymerase chain polymerase chain reaction post infection reference standard Release repeated Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sensitivity Seroconversion serological serological assays serology seronegative Specificities specificity T cell T cell response [DOI] 10.1371/journal.pone.0258041 PMC 바로가기 [Article Type] Research Article
Case Report of COVID-19 after Full Vaccination: Viral Loads and Anti-SARS-CoV-2 AntibodiesCase Report Published on 2021-09-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Alpha variant Analysis anti-SARS-CoV-2 antibodies antibody B.1.1.7 COVID-19 demonstrated effective vaccine expected immune responses indicated Infection load manifested mild COVID-19 symptoms mRNA vaccine Prevent produced report reported SARS-CoV-2 SARS-CoV-2 lineage sore throat Stage Viraemia viral genome sequence Viral load viral loads virus with COVID-19 [DOI] 10.3390/diagnostics11101815 PMC 바로가기 [Article Type] Case Report
BNT162b2 Vaccination Elicits Strong Serological Immune Responses Against SARS-CoV-2 Including Variants of Concern in Elderly ConvalescentsBNT162b2 백신 접종은 노인 요양기의 우려 변종을 포함하여 SARS-CoV-2에 대한 강력한 혈청학적 면역 반응을 이끌어냅니다Observational Study Published on 2021-09-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 임상, 진단, [키워드] Against age analyzed anti-Spike IgG Antibody titer Antibody titers B.1.1.7 B.1.351 benefit binding domain BNT162b2 Care Comirnaty concern convalescent individual COVID-19 COVID-19-convalescent individual cross-reactive Efficacy elderly End End points Gender IgA titer IgA titers IgG titers immune response immune responses Including individual Long-term care MOST mRNA vaccine mutated neutralization capacity neutralization test Neutralizing neutralizing capacity P.1 pre-vaccination prospective observational cohort response SARS-CoV-2 SARS-CoV-2 receptor serological serum significantly higher strength Strong subject vaccination Vaccine vaccinees variants of concern VOCs [DOI] 10.3389/fimmu.2021.743422 PMC 바로가기 [Article Type] Observational Study
mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P.1 Brazilian variant80세 이상의 사람들에서 mRNA 백신 접종은 P.1 브라질 변이체의 교차 중화와 함께 SARS-CoV-2에 대한 강한 체액성 면역 반응을 유도합니다Research Article Published on 2021-09-292022-09-10 Journal: eLife [Category] SARS, 변종, 진단, [키워드] age antibody Antibody Response Antibody responses BNT162b2 BNT162b2 mRNA vaccine Brazil Cellular immune response cellular response Cellular responses correlated COVID-19 COVID-19 vaccination cross detectable Donor dual effective Efficacy Human humoral humoral immune response Humoral immunity Humoral response immune responses immunosenescence induce Infection Mortality mRNA vaccination mRNA vaccine neutralization neutralization titer neutralization titers Older P.1 P.1 variant Pfizer platform reduced remained risk factor SARS-CoV-2 SARS-COV-2 infection second vaccination sera serological Spike protein Spike-specific cellular immune responses These data trials vaccination Vaccine vaccine response vaccine responses variant Victoria [DOI] 10.7554/eLife.69375 PMC 바로가기 [Article Type] Research Article
The Rise of Vectored Vaccines: A Legacy of the COVID-19 Global CrisisReview Published on 2021-09-292022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition amplitude approved China clinical trials COVID-19 COVID-19 pandemic crisis Effectiveness effort EUA favor highlight immune responses immunization immunogen Influenza virus involved janssen Johnson & Johnson legacy New New coronavirus platform recombinant viral vectors Research SARS-CoV-2 the vaccine Tianjin triggered Vaccine vaccinia vectors Viral vector virus [DOI] 10.3390/vaccines9101101 PMC 바로가기 [Article Type] Review
Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19COVID-19에 대해 DNA 나노백신을 보호하고 전달하는 분리형 마이크로니들 패치Article Published on 2021-09-282022-09-11 Journal: ACS Nano [Category] SARS, 치료법, [키워드] adaptive Adaptive immunity administration Against coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine decrease decreases DNA DNA vaccine DNA vaccines feature IFN-γ IgG IL-2 immune immune adjuvant Immune cell immune cells immune responses Immunity immunization in vivo Intramuscular injection lymph nodes Microneedle nucleic acid nucleic acid vaccine nucleocapsid pandemic patch Polymer Protein room temperature separable microneedle. significantly increased storage T cell T cells temperature tissue treated vaccination Vaccine Vaccines virus [DOI] 10.1021/acsnano.1c03252 PMC 바로가기 [Article Type] Article