The role of hematological parameters in COVID-19 patients in the emergency roomResearch Article Published on 2020-07-212022-10-28 Journal: Biomarkers in Medicine [Category] COVID-19, SARS, [키워드] Biomarker Biomarkers Blood can be used Confirmed COVID-19 infection COVID-19 COVID-19 patient Diagnosis diagnosis of COVID-19 emergency medicine evaluated group hematological parameter hemoglobin Infection leukocyte lymphocyte material neutrophil neutrophil lymphocyte ratio NLR parameters Patient peripheral Peripheral blood Platelet platelet lymphocyte ratio Pneumonia Real-time PCR SII statistically significant difference systemic inflammatory systemic inflammatory index [DOI] 10.2217/bmm-2020-0317 PMC 바로가기 [Article Type] Research Article
Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive studyResearch Article Published on 2020-07-162022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] acute respiratory syndrome age alanine aminotransferase albumin Analysis analyzed Aspartate aminotransferase biochemical biochemical marker biochemical parameter C-reactive protein caused Characteristics clinical feature Comorbidity coronavirus Coronavirus disease 2019 Correlation analysis COVID-19 Critical Critically ill patient cross-sectional D-dimer disease severity erythrocyte sedimentation rate Glucose groups helping High-density lipoprotein cholesterol identify Infectious disease lactate dehydrogenase Lymphocyte count Mild mortality rate neutrophil count parameter Patient Peripheral blood plasma Potassium prevented procalcitonin prognostic indicator Result ROC Curve SARS-CoV-2 serum serum amyloid severe patients single center Spread the disease total bilirubin white cell with COVID-19 Wuhan [DOI] 10.1186/s12879-020-05242-w PMC 바로가기 [Article Type] Research Article
Why the elderly appear to be more severely affected by COVID ‐19: The potential role of immunosenescence and CMVReview Published on 2020-07-152022-10-29 Journal: Reviews in Medical Virology [Category] COVID-19, SARS, [키워드] accelerate affected affecting approach children clinically CMV coronavirus disease COVID COVID‐19 cytokine Cytokine storm cytomegalovirus disease evaluate IL‐6 immune immune response immunosenescence individuals Infection Inflammatory investigated mortality rate Older pandemic Peripheral blood promoted Research shown significantly higher silent susceptible T cell phenotype [DOI] 10.1002/rmv.2144 PMC 바로가기 [Article Type] Review
Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19Research Article Published on 2020-07-152022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition analyzed B lymphocytes Bacterial C-reactive protein C1q cause caused CD16 CD19 CD3 CD4 CD56 CD8 China clinical complement coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical death dysregulation early stage electronic medical record eosinophil Excessive activation Health hematological parameters hemoglobin IL-6 immune immune dysregulation immunological characteristics IMPROVE Infection Inflammatory cytokine Inflammatory cytokine storm inflammatory storm laboratory data Lymphocyte count mechanism Mild mortality rate National Health Commission Neutrophils NHCC NK cell NK cells Novel coronavirus outbreak parameters particularly prominent in Pathogens Patient patients Peripheral blood procalcitonin provide SARS-CoV-2 severe cases severely ill patient significantly significantly increased stratified T lymphocytes with COVID-19 [DOI] 10.1128/mSphere.00362-20 PMC 바로가기 [Article Type] Research Article
Comprehensive mapping of immune perturbations associated with severe COVID-19Research Articles Published on 2020-07-152022-10-28 Journal: Science Immunology [Category] COVID-19, Fulltext, SARS, [키워드] Activation adaptive analyzed Comprehensive Critical disease severity dysregulated feature healthy donor host response hyperinflammation immune immune correlate individuals Infection innate cell leukocyte lineages lymphocyte moderate modulation neutrophil Organ failure patients Peripheral blood Perturbation prognostic biomarker receptor SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity T cell activation therapeutic [DOI] 10.1126/sciimmunol.abd7114 PMC 바로가기 [Article Type] Research Articles
Immunologic Effects of Vitamin D on Human Health and DiseaseReview Published on 2020-07-152022-10-30 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] 1,25-dihydroxyvitamin D 25-hydroxyvitamin D active form activity adaptive immune system administration Autoimmune disorders benefit clinical trial component conducted COVID-19 debatable determine diabetes disease disorders Effect Efficacy endothelial endothelial membrane stability Evidence Gene Expression Health healthy Human immune function immune-related disease Immunologic immunomodulation immunomodulatory increased risk individual Infectious diseases Inflammation inter-individual less Lymphocytes macrophages maintain membrane metabolism metabolite Monocytes mononuclear cell multiple sclerosis outcomes Peripheral blood phosphate Regulation respiratory infection responsible rheumatoid arthritis Sepsis serum 25-hydroxyvitamin D shown stability Treatment Tuberculosis Type 1 diabetes Vitamin D Vitamin D supplementation [DOI] 10.3390/nu12072097 PMC 바로가기 [Article Type] Review
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19COVID-19 및 인플루엔자의 면역표현형은 중증 COVID-19 발병에서 I형 인터페론의 역할을 강조합니다Research Articles Published on 2020-07-102022-09-14 Journal: Science Immunology [Category] Fulltext, SARS, 유전자 메커니즘, 진단, [키워드] accompanied acute respiratory distress blood immune cell Cell classical monocyte coronavirus disease COVID-19 driving exacerbating exhibited Factor feature healthy donors highlight hyper-inflammation identify Immunophenotyping Inflammation Inflammatory Inflammatory response Influenza Mild mononuclear cell Patient PBMCs performed Peripheral blood progression reveal RNA sequencing SARS-CoV-2-infected individual severe COVID-19 single-cell RNA-seq syndrome systemic inflammation type I Type I IFN type I interferon with COVID-19 [DOI] 10.1126/sciimmunol.abd1554 PMC 바로가기 [Article Type] Research Articles
Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease종단적 COVID-19 프로파일링은 IL-1RA 및 IL-10을 질병 중증도와 연관시키고 RANTES를 경증 질병과 연관시킵니다Research Article Published on 2020-07-092022-09-25 Journal: JCI Insight [Category] SARS, 바이오마커, 진단, [키워드] Adaptive immunity Beijing You’an Hospital Blood CCL5 chemokine China Clinical management Combination COVID-19 COVID-19 disease severity COVID-19 patients cytokine Cytokines disease disease severity early stage elevated enrolled expression Follow-up GM-CSF healthy volunteers hospitalized COVID-19 patient identifying IFN-γ IL-1 receptor antagonist IL-10 IL-1ra IL-6 immune immune correlate immunoassay Infection inhibitory Intervention laboratory-confirmed late stage longitudinal majority Mild mild cases Mild symptom multiplex no significant difference outcomes Patient patients Peripheral blood predict Prevent prognostic biomarker RANTES severe COVID-19 illness severe disease significantly symptom onset Temporal analysis the cytokine storm TNF-α Treatment strategies Vaccine virus infection with mild disease [DOI] 10.1172/jci.insight.139834 PMC 바로가기 [Article Type] Research Article
Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumoniaArticle Published on 2020-07-062022-10-04 Journal: Nature Communications [Category] SARS, 치료기술, 치료법, 치료제, [키워드] affected alteration anti-inflammatory cytokines both groups CD4 CD4-positive T cells CD57 CD8 cells central memory chemokine chemokine receptors condition COVID-19 COVID-19 patient cytokine production Cytokines effector memory flow cytometry healthy controls IL-17 immune system immunological Immunological memory interferon-γ Italy less lymphocyte Lymphocyte differentiation naïve Necrosis observation pandemic pathophysiological Patient patients with COVID-19 PD1 Peripheral blood Pneumonia proinflammatory proliferate public health Regulatory T cell required SARS-CoV-2 Significant significant increase T cell T cell activation T cells T helper terminally differentiated therapeutic strategy TNF transcription factor viral infection [DOI] 10.1038/s41467-020-17292-4 PMC 바로가기 [Article Type] Article
Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem managementCase Report Published on 2020-07-032022-10-28 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID-19, MERS, SARS, [키워드] Analysis Antigen Antimicrobials aspergillosis Aspergillus clinically Confirmed confirmed case COVID-19 died Evidence Frequency Infection invasive IPA management mechanical ventilation nucleotide Occurrence Patient performed Peripheral blood Postmortem evidence pulmonary SARS-CoV-2 infections Sequencing severe COVID-19 Support vasopressor support [DOI] 10.1590/0037-8682-0401-2020 PMC 바로가기 [Article Type] Case Report