SARS-CoV-2 pandemic – Page 54 – Communicable Diseases Research

COVID-19 and antimalarials. Have we been doing it wrong all along?

코로나19와 말라리아 치료제. 우리가 그동안 잘못 해왔습니까?

Article

Published on 2021-01-152022-08-31
Journal: European journal of pharmacology [Category] MERS, SARS, 신약개발, 치료제,

Polish Experiences of Safety Measures Involving Forensic Psychiatric Inpatients Implemented During the SARS-CoV-2 Pandemic

Psychiatry

Published on 2021-01-152022-10-31
Journal: Frontiers in Psychiatry [Category] COVID-19,

Impact of SARS-CoV-2 pandemic among health care workers in a secondary teaching hospital in Spain

스페인의 중등 교육 병원에서 의료 종사자들 사이에 SARS-CoV-2 대유행의 영향

Research Article

Published on 2021-01-142022-09-10
Journal: PLoS ONE [Category] MERS, 치료기술,

[키워드] age appearance assigned carried category compatible symptom compatible symptoms continuous surveillance COVID-19 COVID-19 pandemic cross-sectional cumulative diagnosis of SARS-CoV-2 doctor group HCW Health Health care worker Health personnel healthcare Healthcare system Healthcare systems healthcare worker Healthcare workers highest hospital identify IgG Impact incidence increased risk individual Infection medical departments medical service medical services medical staff molecular occupational occupational health organizations Patient positive presenting symptom presenting symptoms Prevalence recruited risk rRT-PCR SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 pandemic serological service Spain Surveillance Symptoms Viral virus women
[DOI] 10.1371/journal.pone.0245001 PMC 바로가기 [Article Type] Research Article

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

혈액 전사체의 질병 중증도별 호중구 서명은 COVID-19 환자를 계층화합니다

Research

Published on 2021-01-132022-08-07
Journal: Genome Medicine [Category] 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome analyzed Asymptomatic available data blood cell blood transcriptome Blood transcriptomics capture Cell changes in clinical Clinical parameters Clinical presentations Co-expression analysis Cohort Combination control sample COVID-19 COVID-19 patient data-driven death disease severity dissect Donor driver drug candidate drug candidates targeting Drug repurposing drug target dysregulated explained granulocyte granulocyte sample Granulocytes groups Host host responses identify immune immune system independent Infection Inflammatory diseases Mild mild respiratory mild respiratory tract infection Molecular disease phenotypes molecular phenotype molecular subgroup neutrophil neutrophil activation Neutrophil activation-associated signature Neutrophils other diseases parameters Patient performed phenotype Phenotypes predicted provide report respiratory respiratory distress Respiratory failure respiratory tract infection Result RNA-Seq SARS-CoV-2 pandemic Severe case severe cases severe COVID-19 patient Severe patient Stratification stratified supplementary material syndrome systemic immune response Transcriptome transcriptomes Viral viral infections was used Whole blood whole blood transcriptome
PMC 바로가기 [Article Type] Research

Overcoming Supply Shortage for SARS-CoV-2 Detection by RT-qPCR

RT-qPCR에 의한 SARS-CoV-2 검출을 위한 공급 부족 극복

Article

Published on 2021-01-132022-09-10
Journal: Genes [Category] MERS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration changed clinical sample collapse Concentration condition coronavirus Cq value Cq values described detection diagnostic diagnostics equipment guanidine guanidine hydrochloride investigated Laboratory limit of detection majority nasopharyngeal nasopharyngeal swabs not affect offer overcome pandemic patients performed primer Primers probe probes processed protocol qualitative detection reagent reagents reduced reducing released respiratory RNA room temperature RT-qPCR Saline Saliva SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 RNA detection severe acute respiratory syndrome Coronavirus specimen stability stocks subsequent supply Swab temperature tested the SARS-CoV-2 Transport validation Viral
[DOI] 10.3390/genes12010090 PMC 바로가기 [Article Type] Article

Estimating internationally imported cases during the early COVID-19 pandemic

초기 COVID-19 전염병 동안 국제적으로 유입된 사례 추정

Article

Published on 2021-01-122022-09-10
Journal: Nature Communications [Category] MERS, 치료기술,

Effectiveness and cost-effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population (CoV-Surv Study): a structured summary of a study protocol for a cluster-randomised, two-factorial controlled trial

일반 인구에서 SARS-CoV-2 감시를 위한 4가지 다른 전략의 효과 및 비용 효율성(CoV-Surv 연구): 클러스터 무작위 2인자 통제 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-082022-09-01
Journal: Trials [Category] MERS, 임상, 진단, 치료기술, 치료제,

[키워드] acceptability Active surveillance activities activity addition Admission age analyzed applicability applied approach Arm ARMS Asymptomatic Asymptomatic carrier Asymptomatic carriers Asymptomatic case Asymptomatic cases best Blinding caused choice clinical clinical symptom Clinical symptoms close contact Cluster cluster-randomised controlled trial Complete completion component conducted Controlled trial Cost effectiveness cost-effectiveness Course COVID-19 defined detection rate determine determined by diagnosed Diagnosis dialectic Disease surveillance dissemination effective Effectiveness element eligible estimate estimates evaluated expected False positives finding followed by Gender General population generate Germany gold gold standard Health healthy hospital household identify implementation include individual individuals infected individual infected individuals Infection information isothermal amplification Laboratory limit Local local public health lockdowns Loop-mediated isothermal amplification mail men and women MONITOR municipality objective Older outbreak outcome pandemic parameter parameters participant Perception Perspective population surveillance population-based surveillance positive positive sample PPS Precision predict preference preferences Prevalence Prevent Primary outcomes Probability prognostic model protocol qPCR Quantitative questionnaire random Random sample randomisation Randomly real time receive Region Registered rejection representing required response rates resulting risk RT-LAMP Saliva saliva samples Sample Sample size sample sizes SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 surveillance SARS-CoV-2 testing SARS-CoV-2 tests Satisfaction screened second secondary Secondary outcomes selected Sensitivity and specificity Spread status Strategy study participant Study participants study participation Study protocol Surveillance Symptom symptomatic test result tested the SARS-CoV-2 threshold Total total sample size Trial Trial registration variety virus website while
[DOI] 10.1186/s13063-020-04982-z PMC 바로가기 [Article Type] Letter

Characteristics of Three Different Chemiluminescence Assays for Testing for SARS-CoV-2 Antibodies

SARS-CoV-2 항체 테스트를 위한 3가지 다른 화학발광 분석의 특성

Research Article

Published on 2021-01-062022-09-12
Journal: Disease Markers [Category] 진단,

[키워드] 95% confidence interval Abbott Diagnostics Accuracy Analytical specificity approach AUC characterized chemiluminescence immunoassay CMIA CMV common-cold comparable coronavirus Coronavirus infection COVID-19 cut-off cut-offs diagnostic EBV electrochemiluminescence immunoassay Endemic Epstein–Barr virus evaluate Evidence healthcare healthy blood donors immunoassay Infection investigated Italy likelihood ratio Luminescence Microparticle NPV participant positive PPV Predictive Probability provided receiver operating characteristic ROC Roche Diagnostics SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody test SARS-CoV-2 pandemic sensitivity serology specificity suggested Switzerland symptoms onset Testing two group USA was determined zone
[DOI] 10.1155/2021/8810196 PMC 바로가기 [Article Type] Research Article

Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19)

입원한 COVID-19 환자의 중증 SARS-CoV-2 감염 예방을 위한 재조합 인간 C1 에스테라제 억제제(conestat alfa): 무작위, 병렬 그룹, 공개 라벨, 다중 센터에 대한 연구 프로토콜의 구조화된 요약 파일럿 시험(PROTECT-COVID-19)

Letter

Published on 2021-01-042022-09-10
Journal: Trials [Category] 임상,

[키워드] 24 hour 24 hours Activation activities acute lung injury addition adjusted Administered administration allergy Antibiotics anticipated anticoagulation arterial Arterial hypertension Basel Blinding BMI Brazil Breast Breast feeding breathing ambient air C-reactive protein C1 esterase inhibitor cardiovascular disease Caregivers changes in Chest Child-Pugh score chronic chronic pulmonary disease chronic renal disease cirrhosis class clinical Clinical improvement clinical trial comparator comparator Patients complement complement system completion conducted Conestat alfa Contact contact activation system contraindication control group Corticosteroids COVID-19 COVID-19 patient CT scan death defined discharge disease disease severity dissemination drug Duration Efficacy and safety element eligibility enrolment evidence of experimental arm family members FIVE followed by history hospital Hospitalization hospitalized patient hypertension ICU IL-6 inhibitor IL-6R improvement Incapacity include inclusion criteria individual Infection inflammatory cascade inflammatory cascades inflammatory proteins inhibitor Interactive Web Response System interim analysis Intravenous injection invasive invasive or non-invasive ventilation investigator-initiated investigators kallikrein kinin system laboratory parameter Liver cirrhosis Local Lung injury mechanical ventilation non-invasive ventilation not blinded number obesity objective Open-label open-label trial Ordinal Scale outcome outcome assessor outcome assessors oxygen oxygen saturation pandemic PaO parallel-group participant Participants Participation Patient performed Pregnancy primary endpoint progression proportion protocol pulmonary disease pulmonary involvement randomised randomization Randomized randomized trial receive recombinant recruited recruitment Registered Remdesivir renal renal disease required risk factor Sample size SARS-COV-2 infection SARS-CoV-2 pandemic scale screened secondary Secondary outcomes severe COVID-19 severe SARS-CoV-2 Standard of care status Study protocol subject supplemental oxygen supplementary material suspicion Switzerland Symptom the SARS-CoV-2 the WHO their family members Tocilizumab Treatment treatment arm Trial Two interim analyses Two interim analysis virological clearance website WHO WHO ordinal scale with COVID-19 X-ray
[DOI] 10.1186/s13063-020-04976-x PMC 바로가기 [Article Type] Letter

Neutralizing antibody titres in SARS-CoV-2 infections

SARS-CoV-2 감염에서 항체 역가 중화

Observational Study

Published on 2021-01-042022-09-10
Journal: Nature Communications [Category] 임상, 진단, 치료기술,

[키워드] antibody Antibody responses Antibody titre assays asymptomatic infection asymptomatic infections asymptomatic patients Chain Reaction Cohort collected decrease Detection limit disease elicit endpoints global public health individuals initial Kinetics Medical research Mild mild or asymptomatic infections neutralization Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody titre neutralizing antibody titres onset of symptom onset of symptoms Patient persist plaque reduction neutralization polymerase chain polymerase chain reaction PRNT remained responses reverse transcription reverse transcription polymerase chain reaction robust RT-PCR RT-PCR detection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic sera seropositive Serum neutralizing antibody severe disease severity specific neutralizing antibody tested titre virus
[DOI] 10.1038/s41467-020-20247-4 PMC 바로가기 [Article Type] Observational Study