SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospitalResearch Article Published on 2020-07-292022-10-28 Journal: BMC Pulmonary Medicine [Category] COVID-19, Fulltext, [키워드] 95% CI adopted approved Area caused Cohort Combined Committee COVID-19 COVID-19 patient COVID-19 patients disease HCW HCWs healthcare worker highest hospital IG IgG and IgM IgM IgM and IgG Immunopathogenesis individual Infection Infectious disease Italian Italy lateral flow immunoassay male males median age Neutralizing antibodies New Novel coronavirus point-of-care Prevalence Rapid recruited Result risk of infection SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgM serological Seroprevalence Test [DOI] 10.1186/s12890-020-01237-0 PMC 바로가기 [Article Type] Research Article
Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trialLetter Published on 2020-07-292022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 acute respiratory syndrome Adults adverse event antiretroviral Antiviral Arm Barcelona blinded Blood Breastfeeding Chloroquine condition confirmed case confirmed COVID-19 case Contact Control control group Controlled clinical trial coronavirus coronavirus disease Corticosteroid COVID-19 declining defined develop disease dissemination double-blind double-blinded Efficacy element eligibility Epidemic equipment evaluate Follow-up group healthcare worker Healthcare workers high risk hospital Hydroxychloroquine hydroxychloroquine treatment identify incidence Infection Intervention intervention group investigator marker multicentre National number Nurse objective Occurrence Older outcome participant Participants PCR physical Placebo placebo tablet polymerase chain positive PCR PPE pre-exposure predict predictor Pregnancy primary endpoint Prophylaxis protocol random randomisation randomised randomised controlled trial Randomized Randomized controlled trial Rapid diagnostic test RDT reached receive recruited reducing Registered Repository Research risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Secondary endpoints Seroconversion serological serology serum sample Spain Spanish Standard of care status Study protocol Symptom Tablet the placebo group the SARS-CoV-2 Treatment Trial website with COVID-19 [DOI] 10.1186/s13063-020-04621-7 PMC 바로가기 [Article Type] Letter
Past, present, and future of COVID-19: a reviewReview Published on 2020-07-242022-10-28 Journal: Brazilian Journal of Medical and Biological Resear [Category] COVID-19, MERS, SARS, [키워드] addition affecting candidate drug clinical impact clinical trials COVID-19 Diagnosis effective Efficacy effort immunization Instrumental molecular molecular test morbidity and mortality origin pandemic produced psychological Impact raised recognizing RT-PCR Safe safety profile SARS-CoV-2 SARS-CoV-2 transmission Science serological social isolation Spread Stage Transmission Treatment trials Vaccine virus [DOI] 10.1590/1414-431X202010475 PMC 바로가기 [Article Type] Review
Structure-based design of prefusion-stabilized SARS-CoV-2 spikesReport Published on 2020-07-232022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] accelerate accelerated characterized Combination COVID-19 pandemic cryo-EM structure develop diagnostics effort exhibiting expression freeze-thaw cycles HexaPro parental prefusion proline substitution Protein SARS-CoV-2 SARS-CoV-2 spike serological Spike protein stability Stress Substitution temperature Testing Vaccine Vaccines variant [DOI] 10.1126/science.abd0826 PMC 바로가기 [Article Type] Report
SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste DisordersCommunication Published on 2020-07-152022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Ageusia Analysis Anosmia Cohort Combination COVID-19 diagnosed diagnosis of COVID-19 disorder enrolled enrolment excluded Immunologic majority Mild symptom mild symptoms molecular Molecular assay nasal swabs olfactory onset of symptom Patient performed positive reported SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 replication SARS-CoV-2 RNA serological Serological assay serology significantly higher stratified Symptom Taste the median the SARS-CoV-2 [DOI] 10.3390/microorganisms8071052 PMC 바로가기 [Article Type] Communication
COVID-19 pandemic: management of patients affected by SARS-CoV-2 in Rome COVID Hospital 2 Trauma Centre and safety of our surgical teamOriginal Paper Published on 2020-07-152022-10-29 Journal: International Orthopaedics [Category] COVID-19, MERS, SARS, [키워드] Admission adopted affected clinical status Contagion coronavirus COVID COVID-19 COVID-19 symptoms Emergency fractures globe health system healthcare hospital Infectious disease lack management material measure Operating room pandemic Patient patients Prevent problems protocol Rapid test Result Rome room Safe SARS-CoV-2 SARS-CoV-2 pandemic sensitivity serological Spread statistical significance surgeon surgical trauma Traumatology treated treatment for COVID-19 unit university worsening [DOI] 10.1007/s00264-020-04715-6 PMC 바로가기 [Article Type] Original Paper
An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessmentArticle Published on 2020-07-062022-10-04 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody testing assays Characteristics correlated COVID-19 COVID-19 pandemic cut-off detect diagnostics eight ELISA functional global pandemic Immunoglobulin implementation Laboratory techniques and procedures Medical research outcome Population screening protective antibodies Receptor binding domain SARS CoV-2 SARS-CoV-2 selected serological Serological assay serology Severity of disease Stage Support variety viral infection Virus neutralization virus neutralizing antibodies [DOI] 10.1038/s41467-020-17317-y PMC 바로가기 [Article Type] Article
COVID-19 Serological Tests: How Well Do They Actually Perform?Review Published on 2020-07-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] absence Accuracy claimed conducted coronavirus disease COVID-19 COVID-19 incidence diagnostic test diagnostic tests discrepancy effective global pandemic highlight Immunity implementation increasingly independent initial Isolation Measures morbidity Mortality performance point-of-care public health quarantine rapid serological test SARS-CoV-2 serological serological diagnostic test Serological testing Spread the disease Vaccine Variability well Wuhan, China [DOI] 10.3390/diagnostics10070453 PMC 바로가기 [Article Type] Review
Immunoinformatic Analysis of T- and B-Cell Epitopes for SARS-CoV-2 Vaccine DesignArticle Published on 2020-07-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D Structures addition Analysis antigenic antigenicity B-cell B-cell and T-cell epitopes B-cell epitope composed conserved coronavirus 2 Critical Diagnosis epitope fusion peptide glycosylated highly antigenic immune evasion immunogenic profile immunological profile Immunotherapy IMPROVE knowledge linear linear B-cell epitope mechanism Mutation neutralization overlap pandemic of COVID-19 Point mutation predicted Protein residue resolved respiratory S protein SARS-CoV SARS-CoV S protein SARS-CoV-2 serological significant decrease Structure T-cell epitope the SARS-CoV-2 trimeric trimeric S protein Vaccine Vaccine design Variation [DOI] 10.3390/vaccines8030355 PMC 바로가기 [Article Type] Article
Sequential serological surveys in the early stages of the coronavirus disease epidemic: limitations and perspectivesShort Communication Published on 2020-07-032022-10-28 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval acute respiratory syndrome Community conducted coronavirus coronavirus disease early stage estimate Health Health Surveys Immunity individual interval limitation over pandemic Perspective reported representing serological serological survey [DOI] 10.1590/0037-8682-0351-2020 PMC 바로가기 [Article Type] Short Communication