Antibiotics – Page 55 – Communicable Diseases Research

SARS-CoV-2 Treatment Approaches: Numerous Options, No Certainty for a Versatile Virus

Pharmacology

Published on 2020-08-262022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Impact of comprehensive molecular testing to reduce antibiotic use in community-acquired pneumonia (RADICAP): a randomised, controlled, phase IV clinical trial protocol

지역사회획득 폐렴(RADICAP)에서 항생제 사용을 줄이기 위한 포괄적인 분자 테스트의 영향: 무작위, 통제된, IV상 임상 시험 프로토콜

Article

Published on 2020-08-202022-09-11
Journal: BMJ Open [Category] MERS, 임상, 진단,

[키워드] 1:1 48 hour 48 hours Admission adverse events antibiotic Antibiotic therapy Antibiotic treatment antibiotic use Antibiotics antimicrobial resistance assigned both group both groups causative agent clinical trial ClinicalTrials community-acquired pneumonia De-escalation death Device Diagnosis diagnostic Diagnostic microbiology effective eligible Endpoint Escalation Ethical approval Ethics ethics committee Health health problem hospital hospitalised Hypothesis Immunosuppressed Impact include intensive care intensive care unit admission International intravenous mechanical ventilation Medical devices Medicine molecular molecular diagnostics null hypothesis Open-label parallel group Patient patients Pneumonia primary endpoint Probability protocol randomisation randomised Randomly readmission receive reduce reducing registration number respiratory respiratory infections Result resulting secondary Secondary endpoints Side effects Spanish stability subject
[DOI] 10.1136/bmjopen-2020-038957 PMC 바로가기 [Article Type] Article

Probiotics at War Against Viruses: What Is Missing From the Picture?

Microbiology

Published on 2020-08-202022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] Against Antibiotics Antiviral antiviral activity Antiviral agents Bacteria Bacteriocins Bifidobacterium cause Cell cholesterol co-infecting COVID-19 COVID-19 patients decrease develop Diseases Effect effective greater gut microbiota help Human Immunity immunomodulating Infection infections intervene intestinal lactic acid lactobacillus metabolite metabolites missing Other over Prevent probiotic bacteria Probiotics reduce reduction in report reported Research risk SARS-CoV-2 secondary infections serum strain therapeutic drug treat treated viral infection virus virus infection viruses
[DOI] 10.3389/fmicb.2020.01877 PMC 바로가기 [Article Type] Microbiology

Synthesis and Antibacterial Activity of New N-Alkylammonium and Carbonate-Triazole Derivatives within Desosamine of 14- and 15-Membered Lactone Macrolides

14 및 15 멤버드 락톤 마크로라이드의 데소사민 내에서 새로운 N-알킬암모늄 및 탄산염-트리아졸 유도체의 합성 및 항균 활성

Article

Published on 2020-08-192024-08-24
Journal: ChemMedChem [Category] 폐렴구균 감염증,

[키워드] Antibacterial Antibiotics click chemistry cytotoxicity drug-ribosome interactions.

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

4,4′-다이아미노디페닐 설폰(DDS) 염증소체 경쟁자로서

Article

Published on 2020-08-192022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, 한센병,

[키워드] 4,4′-diaminodiphenyl sulfone (dapsone) Activation AD Alter Alzheimer’s disease Alzheimer’s disease Antibiotics binding caspase-1 cause cleaved Cognitive impairment Combination DDS demonstrated diagnosed Diseases effective Effects Factor Fever fibrosis genetic polymorphisms Hansen’s disease human disease immune response implicated Inflammasome inflammasomes intracellular domain involved Korean lepromatous leprosy (also known as Hansen’s disease) leprosy ligands LL Lung inflammation MADDS mechanism microbial Mild molecular monoacetyldapsone MPO Mutation myeloperoxidase NACHT, LRR and PYD domains-containing protein 3 NLRP3 NLRP3 inflammasome Parkinson’s disease Patient protein 3 receptor Regulation reported responsible S protein SARS-CoV SARS-CoV-2 Sulfone susceptibility tested TLR TLR2 TLRs Toll-like receptor treated Treatment type 2 diabetes variety viruses zoonotic
[DOI] 10.3390/ijms21175953 PMC 바로가기 [Article Type] Article

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

Medicine

Published on 2020-08-072022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Against Analysis Antibiotics Antiviral antiviral activities antiviral activity Antiviral assays approved boost Candidates caused Compound compounds COVID-19 disease Diseases Drug discovery effective Efficacy Health include MDR medicinal plants Medicine metabolite microbe multidimensional natural natural therapeutics/alternative medicine pandemic Pandemics plant reported Research Resistant respiratory SARS-CoV-2 Scientific community screened Secondary Metabolite secondary metabolites stimulate Structure suggested susceptible therapeutic therapeutic potential Therapeutics therapy treat Treatment viral pathogens viruses worldwide pandemic
[DOI] 10.3389/fmed.2020.00444 PMC 바로가기 [Article Type] Medicine

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

Article

Published on 2020-08-042022-10-04
Journal: Scientific Reports [Category] MERS, 신약개발, 치료제,

Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells A case report

4900

Published on 2020-07-312022-10-30
Journal: Medicine [Category] COVID-19, SARS,

[키워드] 2019 novel coronavirus Antibiotics blood pressure body temperature Case report Cell Chest clinical Clinical outcome Corticosteroid COVID-19 COVID-19 case COVID-19 patient Critically ill Critically ill patient critically ill patients develop diagnosed Diagnosis effective fatigued Fever ICU immune response indicated Inflammation injection Laboratory mesenchymal stem cell modulate Mortality Patient patients patients died Pneumonia real-time RT-PCR test reported SARS-CoV-2 severe inflammation shown Side effect SPO sputum stem cell Symptom the patient therapeutic strategy throat swab tissue Tolerance transfer transferred treated Treatment umbilical were given
[DOI] 10.1097/MD.0000000000021429 PMC 바로가기 [Article Type] 4900

Microbiota-independent antiviral effects of antibiotics on poliovirus and coxsackievirus

article

Published on 2020-07-312024-09-01
Journal: The Orthopedic clinics of North America [Category] 폴리오,

[키워드] Antibiotics coxsackievirus microbiota Poliovirus
[Article Type] article

A Panel of Broad-Spectrum Antivirals in Topical Ophthalmic Medications from the Drug Repurposing Approach during and after the Coronavirus Disease 2019 Era

Review

Published on 2020-07-302022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome Antibiotics Antiviral antiviral action Antiviral treatment approach Asymptomatic caused characterized clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) courses COVID-19 described drug Effect explain eye drop eye drops General population heterogeneous group hospitalized patient indicate ingredient investigated medication medications Ocular surface ophthalmic Panel patients with COVID-19 Prevalence public health reported repurposing SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Side effect Symptom therapy topical Treatment Treatment protocol viral infection viruses widespread
[DOI] 10.3390/jcm9082441 PMC 바로가기 [Article Type] Review