cause – Page 55 – Communicable Diseases Research

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics

Article

Published on 2022-01-012022-10-30
Journal: iScience [Category] COVID-19,

Animal Models of COVID-19: Transgenic Mouse Model

Article

Published on 2022-01-012022-11-15
Journal: Methods in molecular biology (Clifton, N.J.) [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome animal animal model Antiviral Brain C57BL/6 cause caused changes in concern coronavirus coronavirus disease COVID-19 COVID-19 disease cytokeratin 18 promoter death described ELISA enzyme-linked immunosorbent evaluated expressing global public health hACE2 hallmark Histopathology human Angiotensin-converting enzyme IHC immune response immunohistochemistry infected intranasally Infection K18 K18 hACE2 transgenic mice lung Lungs Model morbidity Mortality mouse mouse model nasal nervous system neutralizing monoclonal antibodies pathogenesis of SARS-CoV-2 pathogenicity pathology Prophylactic protocol respiratory tracts responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain spleen Spread survival the cytokine storm therapeutic tissues transgenic transgenic mice Treatment Vaccine viral pathogenesis viral replication virus Wuhan, China
[DOI] 10.1007/978-1-0716-2111-0_16 PMC 바로가기

Drug similarity and structure-based screening of medicinal compounds to target macrodomain-I from SARS-CoV-2 to rescue the host immune system: a molecular dynamics study

숙주 면역계를 구하기 위해 SARS-COV-2로부터 마크로 도메인 -I를 표적화하기위한 약용 화합물의 약물 유사성 및 구조 기반 스크리닝 : 분자 역학 연구

Article

Published on 2022-01-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제,

[키워드] active site ADPr Analysis approaches cause caused Compound coronavirus Critical docking docking score drug drug similarity drug target free energy Free energy calculations help Host host immune system identify immune immune system in viral Infection inhibit Interaction macrodomain Macrodomain-I molecular molecular dynamics Molecular dynamics simulation outbreak positive control public health repeated Replication reported researcher residue residues risk SARS-CoV-2 screened severe pneumonia significantly similarity small molecule small molecule inhibitor Small molecule inhibitors structure-based screening targets the disease these compound these compounds vaccine candidate vaccine candidates Viral viral replication Virtual screening Wuhan Wuhan, China
[DOI] 10.1080/07391102.2020.1815583 PMC 바로가기 [Article Type] Article

Low in-hospital mortality rate in patients with COVID-19 receiving thromboprophylaxis: data from the multicentre observational START-COVID Register

혈전 예방을 받는 COVID-19 환자의 낮은 병원 내 사망률: 다기관 관찰 START-COVID Register의 데이터

Observational Study

Published on 2022-01-012022-09-12
Journal: Internal and Emergency Medicine [Category] MERS, 임상, 진단,

[키워드] Admission affected Antithrombotic Atrial fibrillation bleeding Cancer cause characteristic Cohort Comorbidities conducted COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient Deep vein Deep vein thrombosis dosage drug DVT enoxaparin fondaparinux heparin high mortality rate Hospital stay Hospitalized hospitalized patients hypertension in-hospital mortality rate interstitial pneumonia Italian low molecular weight low molecular weight heparin major bleeding majority Mortality mortality rate mortality rates multicentre multivariable multivariable analysis Neurological disease observational study outcome pathology Patient patients hospitalized patients older patients with COVID-19 Pulmonary embolism receive receiving reduction retrospective severe interstitial pneumonia significantly survival thromboembolic thromboembolic disease Thromboembolism Thromboprophylaxis thrombosis thrombotic thrombotic event Thrombotic events treated Treatment Venous Thromboembolism
[DOI] 10.1007/s11739-021-02891-w PMC 바로가기 [Article Type] Observational Study

Potential therapeutic effect of glucagon-like peptide-1 receptor agonists on COVID-19-induced pulmonary arterial hypertension

Research article

Published on 2022-01-012022-10-05
Journal: Medical Hypotheses [Category] 바이오마커, 변종,

[키워드] “cytokine storm” acute respiratory syndrome agonist anti-inflammatory action attenuate Autopsy blood glucose cause caused characteristic Characteristics combating coronavirus Coronavirus disease 2019 coronavirus SARS-CoV-2 COVID-19 COVID-19 infection COVID-19 patient cytokine production Cytokine storm death glucagon Glucagon like peptide-1 receptor agonists glycemic control Infectious disease inflammatory lung damage Lung function Lung injury lung tissue mice PAH pandemic Patient people with COVID-19 PHA Pneumonia Potential pulmonary arterial hypertension pulmonary inflammation recent receptor reduce Regulation responsible SARS-CoV-2 therapeutic effect therapeutic strategy Vascular
[DOI] 10.1016/j.mehy.2021.110739 [Article Type] Research article

Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID Orchitis in Brothers

전체 엑솜 시퀀싱은 NACAD의 희귀 돌연변이를 형제에서 COVID Orchitis의 가능한 원인으로 식별합니다

Case Reports

Published on 2022-01-012022-09-11
Journal: Urology [Category] 변종,

[키워드] ACE2 blood sample Blood samples Brother cause chromosome chromosome 7 circulating COVID COVID-19 develop evaluated genetic mutation genetic mutations Genetic variant Hypothesis men NACAD orchitis pilot study reported risk susceptibility testicular pain
[DOI] 10.1016/j.urology.2021.09.021 PMC 바로가기 [Article Type] Case Reports

Omicron variant of SARS-CoV-2 infection elicits cross-protective immunity in people who received boosters or infected with variant strains

Article

Published on 2022-01-012022-11-16
Journal: International journal of immunopathology and pharm [Category] SARS, 변종,

From Molecular Pathology of COVID 19 to Nigella Sativum as a Treatment Option: Scientific Based Evidence of Its Myth or Reality

COVID 19의 분자 병리학에서 치료 옵션으로 Nigella Sativum까지: 신화 또는 현실에 대한 과학적 근거 증거

Review

Published on 2022-01-012022-09-11
Journal: Chinese journal of integrative medicine [Category] SARS, 유전자 메커니즘, 진단, 치료기술,

Central hubs prediction for bio networks by directed hypergraph – GA with validation to COVID-19 PPI

Short communication

Published on 2022-01-012022-10-05
Journal: Pattern Recognition Letters [Category] 변종,

[키워드] ACE2 Algorithm Analysis applied cause Centrality measures COVID-19 Critical Degree centrality Directed hypergraph Diseases drug design effective enzyme Genetic algorithm human protein interactions mathematical Measures network PPI Protein quartiles Standard deviation statistical Strong tie Structure therapeutic TMPRSS2 Viral protein Weak tie
[DOI] 10.1016/j.patrec.2021.12.015 [Article Type] Short communication

Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs

Review article

Published on 2022-01-012022-10-05
Journal: European journal of medicinal chemistry [Category] 비임상,