COVID-19 pandemic: A review based on current evidenceReview Article Published on 2020-06-032023-06-15 Journal: Indian journal of pharmacology [Category] MERS, SARS, [키워드] Coronavirus disease-19 Drug repurposing pandemic severe acute respiratory syndrome-coronavirus-2 [DOI] 10.4103/ijp.IJP_310_20 PMC 바로가기 [Article Type] Review Article
Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposingCOVID-19 약물 용도 변경을 위한 SARS-CoV-2 엔도사이토시스 이해Review Published on 2020-06-022022-08-31 Journal: The Febs Journal [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome airway airway epithelial cells approved blocker blockers candidate caused Cell Cell Biology cellular mechanism cellular mechanisms characterisation clinically concerning coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 Diversity drug Drug repurposing effective Endocytic pathway endocytic pathways endocytosis epithelial epithelial cells generic drug generic drugs host cell human cell human lung epithelium Infection inhibit knowledge lack mechanism membrane membrane trafficking methodology Outbreaks pandemic paradigm Pathogenesis Pneumonia PROTECT quest Research respiratory responsible SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 virus SARS‐CoV‐2 Severe acute respiratory syndrome shown Taking therapeutic potential Treatment understanding virus viruses [DOI] 10.1111/febs.15369 PMC 바로가기 [Article Type] Review
Thalidomide-Revisited: Are COVID-19 Patients Going to Be the Latest Victims of Yet Another Theoretical Drug-Repurposing?Immunology Published on 2020-05-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] “cytokine storm” absence airway anti-inflammatory drug Anti-viral clinical trial complementary complications of COVID-19 coronavirus disease COVID-19 COVID-19 patient Cytokine storm drug Drug repurposing effective Effectiveness Efficacy and safety Efficiency Evidence exaggerated inflammatory response FDA approval Health inflammatory complication lack lung lung injuries Lung injury Multiple myeloma occur offer outcome pandemic Patient positive progression pulmonary diseases Registered respiratory complication subsequent thalidomide treated Vaccine victim viral infection [DOI] 10.3389/fimmu.2020.01248 PMC 바로가기 [Article Type] Immunology
Virtual screening of immunomodulatory medicinal compounds as promising anti-SARS-COV-2 inhibitorsResearch Article Published on 2020-05-212022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome acute toxicity Analysis analyzed Antiviral antiviral activity binding energy cause Compound compounds Coronavirus-2 disease distribution Drug repurposing Evidence ferulic acid Genistein Hydrogen bond immunomodulatory inhibitor Interaction material metabolism molecular docking morbidity Mortality nonstructural protein pharmacokinetic pharmacokinetics Proteases provide residue responsible resveratrol severe acute respiratory syndrome-2 significant interaction Spike protein these compounds Toxicity Treatment viral disease Viral protein Viral proteins virus [DOI] 10.2217/fvl-2020-0079 PMC 바로가기 [Article Type] Research Article
Identification of Repurposable Drugs and Adverse Drug Reactions for Various Courses of COVID-19 Based on Single-Cell RNA Sequencing DataArticle Published on 2020-05-162022-10-28 Journal: ArXiv [Category] COVID-19, [키워드] Adverse Adverse drug reaction anti-SARS-CoV-2 anti-virus drug approach candidate clinical trial Compound Coronavirus disease 2019 COVID-19 dataset Disease progression drug Drug repurposing drugs effective Efficacy evaluate FDA-approved drug Gene Expression Health highlighting identification identify impacted influenza A virus inhibitory effect library Library of Integrated Network-Based Cellular Signatures LINCS Mild reaction Replication RNA SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patients signature Single-cell RNA sequencing single-stranded ssRNA Systems biology tested virus PMC 바로가기 [Article Type] Article
Artificial intelligence approach fighting COVID-19 with repurposing drugsOriginal Article Published on 2020-05-152023-06-14 Journal: Biomedical journal [Category] MERS, SARS, [키워드] AI COVID-19 DNN Drug repurposing Feline coronavirus SARS-CoV-2 [DOI] 10.1016/j.bj.2020.05.001 PMC 바로가기 [Article Type] Original Article
Drug repurposing against COVID-19: focus on anticancer agentsReview Published on 2020-05-122022-10-29 Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, MERS, SARS, [키워드] anticancer anticancer drugs BCG Body boost Cancer cancer cell Cancer cells Cancer therapy cancer treatment clinical trials Clinical use compassionate use comprehensive analysis COVID-19 COVID-19 outbreak COVID-19 pandemic dosage drug Drug repurposing effective energy metabolism ENhance feature health emergencies Human immune response information knowledge medication MOST nucleic acids pathway phase III trial preclinical study Protein SARS-COV-2 infection therapeutic approaches therapy time-consuming Toxicity Treatment Viral pneumonia viral replication virus-infected cell [DOI] 10.1186/s13046-020-01590-2 PMC 바로가기 [Article Type] Review
Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2’- O -Methylation of Viral RNAArticle Published on 2020-05-102022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome binding mode catalytic clinical feature complexes computational screening Coronavirus-2 COVID-19 de novo docking drug Drug repurposing DrugBank experimental drug food functional Innate innate immune intermolecular interaction lifecycle Methylation methyltransferases molecular molecular docking molecular dynamics overlapping pandemic pharmacological Potential predicted Repository Respiratory disease RNA SARS-CoV-2 SARS-CoV-2 RNA stability stimulatory subunit targeting unique Viral RNA Virtual screening [DOI] 10.3390/v12050525 PMC 바로가기 [Article Type] Article
Janus kinase inhibitor baricitinib is not an ideal option for management of COVID-19Research article Published on 2020-05-012022-10-05 Journal: International journal of antimicrobial agents [Category] SARS, 신약개발, [키워드] Baricitinib Corona virus COVID 19 COVID-19 Drug repurposing drugs global pandemic Infection inhibit inhibitor Janus kinase management novel corona virus outbreak pandemic pathogen researcher SARS-CoV-2 therapeutic option Wuhan [DOI] 10.1016/j.ijantimicag.2020.105967 [Article Type] Research article
COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?Research Perspective Published on 2020-04-302022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] ACE-2 age aging angiotensin-converting enzyme 2 antibiotic Antibiotics association Azithromycin Beta-galactosidase CD26 cellular China clinical trial Compound Corona virus COVID-19 COVID-19 disease COVID-19 infection disease doxycycline drug Drug repurposing FDA-approved drugs functional host receptor Hydroxy-chloroquine Hypothesis IL-6 inhibit inhibitor marker MERS Middle East mortality rate Other pandemic Patient preventing the transmission prevention prevention of COVID-19 profiles protein synthesis quercetin question Rapamycin respiratory resulting SARS-CoV-2 SASP senescence senolytic drug therapy Side-effect Spread Treatment viral replication virus zoonotic [DOI] 10.18632/aging.103001 PMC 바로가기 [Article Type] Research Perspective