immune responses – Page 55 – Communicable Diseases Research

Profile of Immunoglobulin G N -Glycome in COVID-19 Patients: A Case-Control Study

COVID-19 환자의 면역글로불린 G N-Glycome 프로필: 사례-대조군 연구

Immunology

Published on 2021-09-232022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

The Immune Response to SARS-CoV-2 and Variants of Concern

SARS-COV-2 및 관심의 변이에 대한 면역 반응

Review

Published on 2021-09-232022-09-10
Journal: Viruses [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Asymptomatic B cell Betacoronavirus Cellular immune response changes in concern coronavirus COVID-19 deaths Frequency humoral Humoral and cellular immune responses hyperinflammation immune protection immune response immune responses individual Infection Mild Mutation outbreak outcome pandemic Patient respiratory response resulting SARS-CoV-2 SARS-COV-2 infection several variant several variants severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease severe pneumonia Spread subsequent T cell T cell response Transmissibility vaccination Vaccine variants of concern Viral viral replication while Wuhan Wuhan, China
[DOI] 10.3390/v13101911 PMC 바로가기 [Article Type] Review

Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19

자체 유지 IL-8 루프는 심각한 COVID-19에서 전혈전성 호중구 표현형을 유도합니다

Research Article

Published on 2021-09-222022-09-12
Journal: JCI Insight [Category] SARS, 진단,

[키워드] activated Activation acute respiratory distress acute respiratory distress syndrome Analysis ARDS attenuate autocrine cascade characterized Coagulation complement Complement cascade contribute contributing to coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical CXCL8 Cytokines Defense degranulation dissect dysregulation functional highlighting identify IL-8 immune response immune responses immunopathology in vitro in vivo Infection initiate interfere intrinsic Lung injury mechanism mice NET NETosis neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils Pathogens Patient patients phenotype positive feedback positive feedback loop procoagulant progression proinflammatory proteomics prothrombotic pulmonary microthrombosis recent reduce respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection self-damage severe acute respiratory distress syndrome severe COVID-19 severe SARS severe SARS-CoV-2 Signaling syndrome systemic targeting therapeutic target transcriptomic transition TRAP Vascular Biology vicious cycle
[DOI] 10.1172/jci.insight.150862 PMC 바로가기 [Article Type] Research Article

Serological Testing Reveals the Hidden COVID-19 Burden among Health Care Workers Experiencing a SARS-CoV-2 Nosocomial Outbreak

혈청학적 검사를 통해 SARS-CoV-2 병원 발병을 경험한 의료 종사자들 사이에 숨겨진 COVID-19 부담이 드러났습니다.

Research Article

Published on 2021-09-222022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol-generating procedure airway amplification antibody Antibody testing approach approaches burden Care chemiluminescent immunoassay Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients detect diagnose diagnosing diagnostic diagnostics Diseases globe Health Health care Health care system health care workers hidden hospital Host iceberg immune response immune responses Infection Infectious diseases Japan molecular NAAT neutralization test Noninvasive ventilation nucleic acid amplification testing observation occurred outbreak pandemic pathogen PCR portion respiratory risk Risk assessment SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2-specific antibodies Seroconversion serological Serological testing serology severe acute respiratory syndrome Coronavirus silent Spread Testing Transmission triggered Viral Viral detection virus neutralization test worker
[DOI] 10.1128/Spectrum.01082-21 PMC 바로가기 [Article Type] Research Article

Comparison of Dried Blood Spots and Venous Blood for the Detection of SARS-CoV-2 Antibodies in a Population of Nursing Home Residents

요양원 거주자 모집단에서 SARS-CoV-2 항체 검출을 위한 건조 혈반과 정맥혈의 비교

Comparative Study

Published on 2021-09-222022-09-12
Journal: Microbiology Spectrum [Category] MERS, SARS, 진단,

[키워드] Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect analyzed antibodies Antibody testing Blood capillary CMIA collected coronavirus COVID-19 DBS sample DBS samples detection dried blood spot Dried blood spots elderly ELISA ELISA cutoff enzyme-linked immunosorbent enzyme-linked immunosorbent assay Euroimmun evaluate Finger prick General population home IgG IgG antibodies immune response immune responses immunoassay immunoglobins implementation iterative Microparticle Nursing nursing home nursing homes Older pandemic performed Population positive Protein ranged reduced reference population reference test resident room temperature SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody sensitivities sensitivity serological test Serological testing Serological tests serology Serosurveillance serum samples specific antibodies Specificities specificity spot statistical study population subjects temperature vaccination venipuncture venous venous blood Whatman
[DOI] 10.1128/Spectrum.00178-21 PMC 바로가기 [Article Type] Comparative Study

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

마카크에서 보조제 SARS-CoV-2 수용체 결합 도메인 나노입자 백신의 효능 및 범위

420

Published on 2021-09-212022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjuvant animals antibody Antibody titers B.1.351 betacoronaviruses breadth CD4+ T cell Cellular immune response cellular response Cellular responses concerning coronavirus Coverage COVID-19 vaccine cross-neutralization activity displaying domain Efficacy eight elicit emergence evaluate ferritin Formulation High-dose highlighting humoral Humoral and cellular immune responses immune responses Immunity lower airway macaque macaques nanoparticle Neutralizing pandemic potency PROTECT Protein QS-21 Rapid receiving Receptor-binding domain reduce Replication respiratory respiratory tract response robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serum neutralizing antibody Seven severe acute respiratory syndrome Coronavirus Significance Spike protein Support T cell T cell responses Th1 the receptor-binding domain the Sarbecovirus the SARS-CoV-2 two-dose regimen undetectable upper and lower airways vaccination Vaccine Vaccine development variant Viral viral replication VoC VOCs WA1/2020
[DOI] 10.1073/pnas.2106433118 PMC 바로가기 [Article Type] 420

Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals

무증상 SARS-CoV-2 감염자의 장기간 상승된 염증성 단백질 수치

Immunology

Published on 2021-09-172022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법,

[키워드] activated activated macrophages Alpha antibodies antibody Asymptomatic asymptomatic individual Asymptomatic individuals CD137 CD4 CD69 clinical feature Clinical features clinical monitoring complications controls correlated declined domain Evidence First wave IL18 immune response immune responses individual individuals Infection infections Inflammation inflammation markers inflammatory effect Level life-threatening marker Monocytes N protein no decrease OSM persistence positive individuals Post-infection Protein S-RBD S100A12 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid seronegative Seropositivity Serum level serum levels severe disease spike spike receptor-binding domain Spread Support T cell T cell response T cell responses the antibody understanding upregulation Viral viral infection viral neutralization
[DOI] 10.3389/fimmu.2021.709759 PMC 바로가기 [Article Type] Immunology

Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants

Article

Published on 2021-09-172022-10-06
Journal: Science (New York, N.y.) [Category] SARS, 진단,

Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

광범위하게 지시된 SARS-CoV-2-특이적 CD4+ T 세포 반응에는 급성 및 소실된 COVID-19 환자의 막 및 핵단백질 내에서 자주 검출되는 펩티드 특이성이 포함됩니다.

Research Article

Published on 2021-09-162022-09-10
Journal: PLoS Pathogens [Category] SARS, 치료기술, 치료법, 치료제,

[키워드] assays Author average binding affinity breadth CD4+ T cell Cohort cohort of patient COVID-19 cytokine data set defined dominant elicited ELISPOT ENCODE enzyme epitope Epitopes Ex vivo examined FIVE Frequency HLA HLA binding HLA class II ICS IFN-γ immune response immune responses immunological Immunopathogenesis in vitro include individual individual immune response interferon interferon-γ intracellular cytokine staining M protein membrane MHC class N protein novel nucleoprotein one patient overlapping Patient patients peptide peptides phenotype Protein resolved response response frequency SARS-CoV-2 envelope SARS-CoV-2 genome SARS-COV-2 infection screened Specificities specificity Spike protein structural protein structural proteins subsequent T cell T cell epitope T cell response T cell responses T cells tetramer the N protein the SARS-CoV-2 the spike protein to define Vaccine design Viral Viral proteins vitro cultivation
[DOI] 10.1371/journal.ppat.1009842 PMC 바로가기 [Article Type] Research Article

Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19

HLA 유전자형, AB0 혈액형 및 케모카인 수용체 5 돌연변이 CD195와 COVID-19의 임상 경과와의 연관성

Observational Study

Published on 2021-09-162022-09-10
Journal: European Journal of Medical Research [Category] 변종, 임상, 진단,

[키워드] ABO blood group absence Adaptive immune response addition addressed age Analysis anti-S IgG anti-S IgG levels Antigen antigens antiviral immune response association benefit Blood Blood Group carriers caused CCR5 Chemokine receptor Clinical course clinical courses Cohort Composite courses COVID-19 COVID-19 convalescent patient Cox regression deletion mutant disease disease severity DRB1 exploratory fatal disease Follow-up genetics genotypes Group antigen heterozygous Hierarchical HLA HLA allele HLA alleles HLA class I HLA class I genotypes HLA class II Human human leukocyte antigen humoral immune responses immunogenetic background infection with SARS-CoV-2 investigated leukocyte median Mild Moderate COVID-19 morbidity mutant Mutation Neutralizing antibodies neutralizing capacity observation observational study pandemic disease parameter patient cohort patient population pauci-symptomatic potential risk presence or absence progression prolonged disease Prospective Protective protective effect reduced required Result SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe disease severity significantly supplementary material the patient vaccination response virus was performed
[DOI] 10.1186/s40001-021-00560-4 PMC 바로가기 [Article Type] Observational Study