SARS-CoV-2 seroprevalence among parturient women in PhiladelphiaReports Published on 2020-07-292022-10-28 Journal: Science Immunology [Category] COVID-19, Fulltext, SARS, [키워드] affected Clinical practice Community COVID-19 donors IgG IgM individual Limited nasopharyngeal over parturient Philadelphia polymerase chain populations positive Pregnancy pregnant women Receptor binding domain SARS-CoV-2 SARS-CoV-2 seroprevalence SARS-CoV-2 spike SARS-CoV-2-specific antibodies serological evidence serological test Serological testing seropositive Surveillance women [DOI] 10.1126/sciimmunol.abd5709 PMC 바로가기 [Article Type] Reports
Structure-based design of prefusion-stabilized SARS-CoV-2 spikesReport Published on 2020-07-232022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] accelerate accelerated characterized Combination COVID-19 pandemic cryo-EM structure develop diagnostics effort exhibiting expression freeze-thaw cycles HexaPro parental prefusion proline substitution Protein SARS-CoV-2 SARS-CoV-2 spike serological Spike protein stability Stress Substitution temperature Testing Vaccine Vaccines variant [DOI] 10.1126/science.abd0826 PMC 바로가기 [Article Type] Report
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsinLetter Published on 2020-06-122022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, Fulltext, SARS, [키워드] absence furin cleavage site Infection membrane fusion Pathogenesis SARS-CoV-2 spike trypsin [DOI] 10.1038/s41392-020-0184-0 PMC 바로가기 [Article Type] Letter
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across TissuesArticle Published on 2020-05-282022-10-31 Journal: Cell [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome airway epithelial cell angiotensin-converting enzyme 2 Anti-viral bind cause Cell cells cellular cellular entry clade coronavirus COVID-19 dataset disease ENhance Enterocyte epithelia epithelial Factor goblet secretory cells Health Host host proteases host response host tissue Human identify ileal absorptive enterocytes implication Infection Influenza interferon interferon-stimulated gene ISG lung Lung injury lung tissue mechanism mouse mouse single-cell RNA-sequencing nasal non-human primate Pathogenesis Pneumocytes promote Protein raising regulate SARS-CoV-2 SARS-CoV-2 spike scRNA-seq single-cell RNA-seq dataset Specific subset target the disease tissue tissues TMPRSS2 TMPRSS2 expression transmembrane serine protease Type type II pneumocytes upregulated upregulation urgency viral infections [DOI] 10.1016/j.cell.2020.04.035 PMC 바로가기 [Article Type] Article
Cell entry mechanisms of SARS-CoV-2530 Published on 2020-05-262022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] ACE2 receptor activated Activation acute respiratory syndrome bind binding affinity biochemical Cell cell entry cells comparable contribute coronavirus coronavirus disease COVID-19 domain Entry mechanism entry receptor feature furin hACE2 hidden highlighting human ACE2 human cell immune immune evasion Intervention investigated less maintain mechanism mechanisms pandemic proprotein convertase furin protease Proteases provide pseudovirus entry assay pseudovirus entry assays RBD receptor Receptor binding reducing SARS-CoV SARS-CoV RBD SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 RBD SARS-CoV-2 spike second Significance Spike protein Spread Surveillance the RBD understanding virus [DOI] 10.1073/pnas.2003138117 PMC 바로가기 [Article Type] 530
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytesResearch Article Published on 2020-05-132022-10-28 Journal: Science Immunology [Category] COVID-19, Fulltext, SARS, [키워드] ACE2 colonic contribute COVID-19 patients Disease progression Enterocyte facilitated fecal Gastrointestinal highlight host cells inactivated infect Infection Infectious virus intestinal intestinal enterocyte intestinal lumen intestine Local promote promoted released replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 virus serine proteases specimen Stool Symptom systemic illness TMPRSS2 TMPRSS4 Transmission virus virus entry [DOI] 10.1126/sciimmunol.abc3582 PMC 바로가기 [Article Type] Research Article
Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-IgArticle Published on 2020-04-242022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome Antiviral treatment binding affinity binding kinetics catalytic activity cell entry receptor characterized coronavirus Coronaviruses cross-reactivity determine Diagnosis domain enzyme Extracellular Fc region fusion protein generate human ACE2 human immunoglobulin IgG1 in vitro inhibit mice mutant neutralize parameter pharmacological Prophylaxis Protein pseudotyped Pseudotyped virus receptor Recombinant protein therapy SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARSCoV-2 shown Spike protein the receptor-binding domain Treatment Vaccine viral infection virus Wuhan, China [DOI] 10.1038/s41467-020-16048-4 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusionArticle Published on 2020-03-302022-10-04 Journal: Cell Research [Category] MERS, SARS, 치료제, [키워드] amino acid residue caused circulating coronavirus coronavirus disease COVID-19 defined develop domain effective electron microscopy examined global public health HCoV-OC43 HR1 domain human coronavirus IC50 Infection inhibit inhibited inhibition inhibitor Interaction membrane fusion MERS-CoV mice molecular mechanism mutated outbreak peptide plasma membrane pseudovirus pseudovirus infection Replication S protein S2 subunit SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARSr-CoVs Spike protein tested the SARS-CoV-2 Treatment viral infection Wuhan, China X-ray [DOI] 10.1038/s41422-020-0305-x PMC 바로가기 [Article Type] Article