Comorbidities Associated with Hospitalization and Progression Among Adolescents with Symptomatic Coronavirus Disease 2019Multicenter Study Published on 2022-06-012023-07-08 Journal: The Journal of pediatrics [Category] COVID19(2023년), [키워드] Adolescent COVID-19 Hospitalization monoclonal antibodies pediatrics [DOI] 10.1016/j.jpeds.2022.02.048 PMC 바로가기 [Article Type] Multicenter Study
[Nirmatrelvir plus ritonavir (Paxlovid) a potent SARS-CoV-2 3CLpro protease inhibitor combination][니르마트렐비르와 리토나비르(팍슬로비드)의 강력한 SARS-CoV-2 3CLpro 프로테아제 억제제 조합]Review Published on 2022-06-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL 3CLpro Administered adverse effects Antiviral antiviral drug antiviral drugs antiviral efficacy approved average conserved coronavirus Coronaviruses death duration of treatment effective Effectiveness EMA English FDA Final Hospitalization IMPROVE indican inhibitory activity media metabolism Modification Nirmatrelvir NSP11 Pandemia pandemic Patient Paxlovid PF-07321332 polyproteins pp1a pp1ab processing protease Protease inhibitor Proteases Proteins reducing risk Ritonavir SARS-CoV-1 SARS-CoV-2 sequence shown Spanish therapeutic target Treatment Viral variants [DOI] 10.37201/req/002.2022 PMC 바로가기 [Article Type] Review
Challenges of rapamycin repurposing as a potential therapeutic candidate for COVID-19: implications for skeletal muscle metabolic health in older personsCOVID-19의 잠재적인 치료 후보로 라파마이신 용도 변경의 도전: 노인의 골격근 대사 건강에 대한 영향Editorial Published on 2022-06-012022-09-11 Journal: American journal of physiology. Endocrinology and [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration affected aging anabolic anabolic resistance antiviral medication attenuate bed rest block blunting causative agent Cell cell growth challenge clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hospitalization death Decline demonstrated downstream drug Drug repurposing Effect effective effective vaccine Effective vaccines effectors greater growth Health healthy Hospitalization Human implication lack master regulator Mortality MPS mTOR muscle loss muscle mass muscle protein muscle protein synthesis muscle protein synthesis. Older pandemic Pandemics Rapamycin reduced resulting risk SARS-CoV-2 sedentariness Severe infection Skeletal muscle Spread susceptible the disease therapeutic with COVID-19 younger patients [DOI] 10.1152/ajpendo.00064.2022 PMC 바로가기 [Article Type] Editorial
Efficacy and safety of hydroxychloroquine in healthcare professionals with mild SARS-CoV-2 infection: Prospective, non-randomized trialClinical Trial Published on 2022-06-012022-10-05 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] COVID19(2023년), SARS, 임상, [키워드] 95%CI Admission asked benefit both groups clinical symptom Comorbidities contraindication Control control group COVID-19 decrease diarrhea died Disease progression Efficacy and safety English female FIVE Follow-up HCQ Health Health care worker Healthcare professional healthcare worker Healthcare workers Hidroxicloroquina Hospitalization Hydroxychloroquine in both groups in viral Infección por SARS-CoV-2 initial intensive care unit Loading dose media median age Mild mild SARS-CoV-2 infection Negative conversion no significant difference non-randomized non-randomized trial outcome outpatients Pacientes externos Patient PCR Pneumonia primer Probability professional Prospective prospectivo reduction in required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load Side effect significant difference Spanish Symptom Trabajadores sanitarios. Treatment treatment group Two patient viral dynamics were given [DOI] 10.1016/j.eimce.2020.10.015 PMC 바로가기 [Article Type] Clinical Trial
COVID-19 infection and treatment-resistant cocaine-induced pyoderma gangrenosum: A case reportCase report Published on 2022-06-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 치료법, [키워드] BSA Burn Case report Cocaine-induced connection COVID COVID-19 COVID-19 infection cutaneous symptoms disease etiology exceptional highlight Hospitalization Infection limb male neutrophilic non-infectious outbreak past medical history Patient positive pyoderma Pyoderma gangrenosum remained transferred Treatment treatment guideline variant worsening [DOI] 10.1016/j.amsu.2022.103828 [Article Type] Case report
Early administration of COVID-19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy살아있는 바이러스 중화 분석에 의한 고역가 항체 함량을 가진 COVID-19 회복기 혈장의 조기 투여는 보통의 임상 효능과 관련이 있습니다Article Published on 2022-06-012022-09-11 Journal: American journal of hematology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absolute reduction administration administration of CCP antibody Antibody titer benefit CCP clinical benefit Clinical efficacy convalescent plasma correlation COVID-19 COVID-19 convalescent plasma Cox regression death rate death rates determined by develop Dilution Efficacy evaluate evaluated Hospitalization hospitalized patient hospitalized patients inhibitory intubated patients multivariable Cox regression neutralized Neutralizing antibody titer Non-intubated non-intubated patient non-intubated patients Patient receiving Risk factors shown stratified titer transfused Treatment two groups Viral viral neutralization viral variant Viral variants was performed with COVID-19 [DOI] 10.1002/ajh.26531 PMC 바로가기 [Article Type] Article
Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORM-a prospective, randomized, single-centre, open-label study염증 표지자가 상승한 입원한 COVID-19 환자에서 토실리주맙의 조기 투여; COVIDSTORM-전향적, 무작위, 단일 센터, 공개 라벨 연구Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 바이오마커, 임상, 진단, [키워드] (interleukin-6 activities addition administration Admission benefit C-reactive protein clinical clinical recovery clinical status control group control patient control patients COVID-19 D-dimer demonstrated discharged elevated ferritin hospital Hospital admission Hospitalization Hospitalized hospitalized COVID-19 patient Hypoxemia immune response Inflammation inflammation markers Inflammatory inflammatory biomarkers intensive care intensive care unit admission interleukin interleukin-6 interquartile range marker median Open-label Ordinal Scale Patient patients hospitalized primary endpoint Randomized respiratory Respiratory Support SARS-CoV-2 secondary endpoint Secondary endpoints seven-category ordinal scale severe COVID-19 significantly SOC Standard of care TCZ Tocilizumab with COVID-19 [DOI] 10.1016/j.cmi.2022.02.027 PMC 바로가기 [Article Type] Randomized Controlled Trial
Humoral response and breakthrough infections with SARS-CoV-2 B.1.617.2 variant in vaccinated maintenance hemodialysis patients예방 접종을 받은 유지 혈액 투석 환자에서 SARS-CoV-2 B.1.617.2 변이체에 의한 체액 반응 및 돌발성 감염Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Nephrology [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 30-Day mortality 95% CI all-cause mortality analysed antibody B.1.617.2 BNT162b2 BNT162b2 vaccine Breakthrough COVID-19 infection Breakthrough infection caused clinical outcomes Control control group COVID-19 COVID-19 case COVID-19 infection Critical disease declining delta variant dose Effectiveness Hematological malignancies Hemodialysis Hospitalization humoral Humoral response Immunosuppression Immunosuppressive treatment Infection investigated maintenance Maintenance hemodialysis morbidity and mortality Mortality mortality rate nosocomial occur occurred Odds ratio outcome overall mortality Patient patients Pfizer-BioNTech required response to vaccination retrospective risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants significantly higher source of infection Spike protein study group Treatment vaccination Vaccine variant [DOI] 10.1007/s40620-022-01245-9 PMC 바로가기 [Article Type] Observational Study
Modelling the risk of hospital admission of lab confirmed SARS-CoV-2-infected patients in primary care: a population-based studyRandomized Controlled Trial Published on 2022-06-012022-10-05 Journal: Internal and Emergency Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] Activation age Analysis Angiotensin-converting enzyme AUC baseline Cancer cardiovascular diseases Coagulopathies collected Comorbidities Coronavirus infections COVID-19 develop diabete drug Emergencies Epidemiology Factors FIVE greater group Health help higher risk hospital Hospital admission Hospitalization immunosuppressants increased risk inhibitors lab Liver disease notable NSAIDS organ damage Patient people with COVID-19 Predictive primary care Primary Health Care randomly divided retrospective cohort study risk risk factor Risk factors SARS-COV-2 infection SARS-CoV-2-infected patient severity Sex sociodemographic data systemic steroids the disease vaccination were used [DOI] 10.1007/s11739-022-02931-z PMC 바로가기 [Article Type] Randomized Controlled Trial
Cerebral venous thrombosis during the COVID-19 Pandemic: A multi-center experienceResearch article Published on 2022-06-012022-10-05 Journal: Clinical neurology and neurosurgery [Category] 변종, [키워드] age anticoagulation association cerebral cerebral vein thrombosis Characteristics Clinical characteristics Comorbidity Complication coronavirus COVID COVID-19 COVID-19 infection Diagnosis hemorrhage Hospitalization hypertension Infection majority male Mortality objective outcome Patient positive COVID-19 Pulmonary emboli Radiographic Result stroke the patient treated vaccination Vaccine venous Venous thrombosis with COVID-19 [DOI] 10.1016/j.clineuro.2022.107256 [Article Type] Research article