Strategies comparison in response to the two waves of COVID-19 in the United States and India미국과 인도의 COVID-19의 두 가지 물결에 대응하는 전략 비교Article Published on 2022-04-292022-09-11 Journal: International journal for equity in health [Category] 변종, 치료기술, [키워드] absence accelerate addition adopted advent caused condition confirmed case confirmed cases containment strategies Containment strategy country COVID-19 COVID-19 outbreak cumulative Deterioration early stage Effectiveness Epidemic evaluated Factor immune India initial initial stage Intervention lack Mask Masks measure medical resource Medical resources mutant National Non-pharmacotherapy intervention outbreak Premature Prevention and control risk Strategy the epidemic the United State The United States and India. United State United States vaccination virus virus detection [DOI] 10.1186/s12939-022-01666-9 PMC 바로가기 [Article Type] Article
Computer-designed repurposing of chemical wastes into drugs Research Published on 2022-04-272022-10-05 Journal: Nature [Category] 신약개발, [키워드] accelerate Algorithm Analysis Comprehensive criteria Degradation drug experiment generate Giant hazards help knowledge Metrics reuse substrate tracing [DOI] 10.1038/s41586-022-04503-9 [Article Type] Research
Anti-tuberculosis treatment strategies and drug development: challenges and priorities Reviews Published on 2022-04-272022-10-05 Journal: Nature reviews. Microbiology [Category] 바이오마커, 진단, [키워드] accelerate animal model benefit Characteristics clinical trial clinically disease severity drug candidate Drug discovery drug response exceptional highlight Host in vitro tool Infection inherent marker MOST organizations pathogen predictor progression pulmonary disease regimen regimens Research review synergy therapy translate Treatment treatment strategy Trial tuberculosis disease [DOI] 10.1038/s41579-022-00731-y [Article Type] Reviews
Controversies about immunoglobulin replacement therapy in HSCT recipients with hypogammaglobulinemia Reviews Published on 2022-04-192022-10-05 Journal: Bone marrow transplantation [Category] 치료제, [키워드] accelerate administration antibody available data Bacterial infection benefit Blood Cell Characteristics chimeric antigen receptor clinical clinical trial CLL deficiency demonstrated disease dosage Efficacy Evidence Hematological malignancy heterogeneous HSCT HSCT recipient Hypogammaglobulinemia IgG immune Immunoglobulin immunoglobulin replacement therapy infection risk leukemia Meta-analysis monoclonal antibody Mortality MOST Multiple myeloma Other other disease Patient Prophylactic randomized trial regimen subsequent T-cell therapy utility [DOI] 10.1038/s41409-022-01680-z [Article Type] Reviews
Rational Design of CRISPR/Cas12a-RPA Based One-Pot COVID-19 Detection with Design of Experiments실험 계획을 통한 CRISPR/Cas12a-RPA 기반 One-Pot COVID-19 탐지의 합리적 설계Article Published on 2022-04-152022-09-11 Journal: ACS synthetic biology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accelerate addition amplification applied approach benefit buffer complex component components condition COVID-19 COVID-19 pandemic CRISPR CRISPR/Cas12a critical impact definitive screening design demonstrated design of experiments detection Detection sensitivity diagnostic Diagnostic method diagnostics DNA DNA sequence DoE Effect effective experiment Factor full-length SARS-CoV-2 Genome highlight isothermal molecular Molecular diagnosis N gene one-pot COVID-19 testing optimization polymerase reaction reaction optimization Reactions recombinase polymerase amplification recombinase polymerase amplification (RPA). reverse transcription RNA RNase RNase inhibitor robust RPA RT-qPCR sensitivity significant effect significantly simple statistical variables [DOI] 10.1021/acssynbio.1c00617 PMC 바로가기 [Article Type] Article
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory CompoundsSARS-CoV-2 3CLpro 억제제에 대한 진행 상황: SARS-CoV 3CLpro 펩티드 모방체 및 소분자 항염 화합물에서 영감Review Published on 2022-04-082022-09-11 Journal: Drug design, development and therapy [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3CLpro accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects Antiviral antiviral target caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Health inhibitor inhibitors inspiration life cycle pathophysiological peptidomimetics Progress protease protease inhibitors Protein proteinase SARS-CoV SARS-CoV-2 sequence homology Sequencing severe acute respiratory syndrome Coronavirus similarity small-molecule inhibitors. viral life cycle whole-genome sequencing [DOI] 10.2147/DDDT.S359009 PMC 바로가기 [Article Type] Review
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytesD-이량체 및 CoV-2 스파이크-면역 복합체는 단핵구에서 PGE2 및 전염증성 사이토카인 생성에 기여합니다Article Published on 2022-04-062022-09-12 Journal: PLoS Pathogens [Category] 진단, [키워드] accelerate activated antibody binding antibody Calcium signaling chimeric Coagulopathy coated with Combination complexes contribute convalescent plasma correlated COVID-19 cytokine D-dimer dose healthy healthy donors hospitalized COVID-19 patient hospitalized COVID-19 patients human monocyte IL-6 IL-8 immune complex increase in infiltrating monocyte Inflammatory cytokine Inflammatory cytokines inflammatory status inhibitor integrin kinase lung Lung pathology MAPK monoclonal antibody monocyte much lower neutralizing antibody titers overreactive inflammatory response pathway Patient PGE2 plasma produced Proinflammatory cytokine prostaglandin E2 pseudovirus recombinant S protein regions responses S protein SARS CoV-2 significantly Treatment viral particle [DOI] 10.1371/journal.ppat.1010468 PMC 바로가기 [Article Type] Article
Early-stage Alzheimer disease: getting trial-ready Reviews Published on 2022-04-042022-10-05 Journal: Nature reviews. Neurology [Category] 바이오마커, 변종, 임상, [키워드] accelerate accelerated Alzheimer disease approval Asia Asymptomatic Biomarker Brain clinical trial Cohort collaboration determine disease effective Efficiency effort eligibility engage Europe example FDA individual initiated medical need Modification North America participant Participants performed progression randomize recruit recruitment required risk Stage study participant symptomatic the disease therapeutic therapeutic intervention therapy Trial trials [DOI] 10.1038/s41582-022-00645-6 [Article Type] Reviews
Can Innovative Trial Designs in Orphan Diseases Drive Advancement of Treatments for Common Neurological Diseases?희귀 질환에 대한 혁신적인 시험 설계가 일반적인 신경계 질환에 대한 치료법의 발전을 주도할 수 있습니까?Review Published on 2022-04-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] 신약개발, [키워드] accelerate accelerated adaptive advancement Advancing Amyotrophic lateral sclerosis approach approval approvals Can clinical trial common complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical disease Diseases drive drugs Duchenne muscular dystrophy Efficacy Evidence Formal Innovation Lateral Sclerosis muscular muscular dystrophy nervous system disorder opportunity Orphan pandemic parkinson s disease Parkinson's Disease progressed rare diseases Regulatory regulatory agency therapeutic Trial [DOI] 10.1002/cpt.2528 PMC 바로가기 [Article Type] Review
COVID-19 interventional trials: Analysis of data sharing intentions during a time of pandemicCOVID-19 중재 시험: 팬데믹 기간 동안 데이터 공유 의도 분석Article Published on 2022-04-012022-09-11 Journal: Contemporary clinical trials [Category] 임상, [키워드] accelerate actual changed Clinical studies clinical study ClinicalTrials.gov Committee COVID-19 Data sharing dataset evaluated expand Follow-up ICMJE inclusion criteria information initial Intention IPD. journal pandemic positive reflected Registered Registration remained Research subset Trial Volunteer [DOI] 10.1016/j.cct.2022.106709 PMC 바로가기 [Article Type] Article