Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control studyResearch Published on 2021-11-172022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] ACE ACE gene ACE2 acute respiratory syndrome adverse effects age AGT AGTR1 allele Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 association C allele case-control study caused cell entry changes in Coronavirus-2 COVID-19 COVID-19 infection COVID-19 pandemic diabete disease evaluate Genotype healthy controls hypertension I/D increased the risk Infection Patient PCR polymerase chain polymorphism Prevalence public health crisis RAS receptor recruited renin-angiotensin system Result risk of COVID-19 SARS-CoV-2 severe disease severity significantly higher subjects susceptibility the disease variant was performed with COVID-19 [DOI] 10.1186/s41231-021-00106-0 PMC 바로가기 [Article Type] Research
The role of fenofibrate in the treatment of COVID-19Short Communication Published on 2021-11-032022-10-04 Journal: Annals of Medicine and Surgery [Category] 치료법, [키워드] ACE Analysis caused Cell COVID-19 COVID-19 patients Effect Fenofibrate help host cell increase in Mortality pandemic Patient positive Prevent receptor reduce regimen S protein Safe SARS-CoV2 SARS-CoV2 infection severity suggested the SARS-CoV-2 virus therapeutic Treatment viral entry viral spike protein virus Wuhan, China [DOI] 10.1016/j.amsu.2021.102974 PMC 바로가기 [Article Type] Short Communication
Whey-Derived Peptides at the Heart of the COVID-19 PandemicCOVID-19 팬데믹의 중심에 있는 유청 유래 펩타이드Article Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] ACE ACE inhibitor ACE inhibitors ACE inhibitory activity ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach association blood pressure blood pressure homeostasis Captopril cells component coronavirus COVID-19 COVID-19 pandemic drugs dual enzyme exhibiting heart human ACE2 hypertension inhibit inhibitory inhibitory action inhibitory activity IPP Lisinopril molecular docking molecular interaction peptide peptide sequences peptides Previous studies produced RAS RAS inhibitor RAS inhibitors receptor reduced risk renin–angiotensin system renin–angiotensin system reported respiratory SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus shown synthetic drugs therapeutic Treatment treatment of COVID-19 were assessed whey peptides [DOI] 10.3390/ijms222111662 PMC 바로가기 [Article Type] Article
Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease MortalityArticle Published on 2021-10-272022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] 95% CI ACE ACE gene ACE1-angiotensin-converting enzyme 1 ACE2 ACE2-angiotensin-converting enzyme 2 addition advanced age age allele allelic amplification Analysis angiotensin angiotensin-converting enzyme 2 Artery association bind Control controls Coronary Coronary artery disease correlation COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 severity diabete distribution facilitate Frequency functional Gender gene polymorphism Genotype genotyping group Health healthy control host cell hypertension I/D I/D polymorphism indicated Infection insertion/deletion International ischemic heart disease Mortality Mutation outbreak P -value Pathogenesis pathogenesis of COVID-19 PCR protective factor public health receptor reported Result rs4240157 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity significant difference Spike protein Strong susceptibility to SARS-CoV-2 susceptible T2D targeted intervention virus entry with COVID-19 [DOI] 10.3390/jpm11111098 PMC 바로가기 [Article Type] Article
The Unintended Consequence of Novel Coronavirus (COVID-19) Pandemic on Racial Inequities Associated With Adverse Childhood Experiences (ACEs): Findings From a Population-Based StudyPublic Health Published on 2021-10-262022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] ACE ACEs Adverse adverse childhood experiences black census childhood children consequence Control coronavirus correlation COVID-19 COVID-19 case COVID-19 pandemic death deaths Department distribution ecological Effect effort experience Factor finding Health inequity Isolation moderate non-normal novel pandemic parental Population protective factor Protective factors reported response rising South Spearman Spearman correlation test Stress Structural racism System variables was used were used [DOI] 10.3389/fpubh.2021.701887 PMC 바로가기 [Article Type] Public Health
ACE2 and Innate Immunity in the Regulation of SARS-CoV-2-Induced Acute Lung Injury: A ReviewReview Published on 2021-10-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 activating Acute respiratory infection acute respiratory syndrome addition ALI alveolar cells Anti-inflammatory Clinical treatment coronavirus COVID-19 Critical Cytokine storm Defense effective drug enzyme Evolution functions host cell immune cells induce infecting Infection Innate Innate immunity Invasion lung metalloproteinase Pathogens RAS receptor Regulation renin-angiotensin system reported resulting review SARS-CoV SARS-CoV-2 target therapeutic target tissue damage [DOI] 10.3390/ijms222111483 PMC 바로가기 [Article Type] Review
The therapeutic potential of the novel angiotensin-converting enzyme 2 in the treatment of coronavirus disease-19Review Article Published on 2021-10-232022-10-29 Journal: Veterinary World [Category] COVID-19, [키워드] ACE ACE2 acute respiratory syndrome alveolar cell angiotensin-converting enzyme 2 benefit Chronic kidney disease coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 pandemic COVID-19 patient disease drug candidate dysregulation ENhance enzyme epithelial cells etiological agent expressed expression global pandemic Google heart failure Hospitalization host cell hypertension immune system Lung injury Lungs management morbidity Mortality other tissue pandemic pharmacological PubMed Central receptor renin-angiotensin system reported SARS-CoV-2 Sex stratified therapeutic potential transmitted Treatment virus [DOI] 10.14202/vetworld.2021.2705-2713 PMC 바로가기 [Article Type] Review Article
Regulation of Angiotensin-Converting Enzyme 2: A Potential Target to Prevent COVID-19?안지오텐신 전환 효소 2의 조절: COVID-19 예방을 위한 잠재적 표적?Review Published on 2021-10-222022-09-12 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 진단, [키워드] ACE ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 binding caused chronic condition Clinical prognosis condition coronavirus coronavirus disease COVID-19 Critical diabetes distribution enzyme Evidence expression expression level homeostasis homolog host cell humans hypertension involved mammals organ pandemic pathology Potential progression RAS receptor renin–angiotensin system SARS-CoV-2 SARS-COV-2 infection susceptibility target therapeutic target tissue injury viral spike protein [DOI] 10.3389/fendo.2021.725967 PMC 바로가기 [Article Type] Review
The Impact of ACE2 Polymorphisms on COVID-19 Disease: Susceptibility, Severity, and TherapyCOVID-19 질병에 대한 ACE2 다형성의 영향: 감수성, 중증도 및 치료Review Published on 2021-10-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE ACE2 ACE2 variant ACE2 variants acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 benefit caused Characteristics circulating combating contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease develop disease Effect effective Epigenetic Ethnicity explain Factor functional Gender gene polymorphism help high morbidity and mortality homeostatic host genetics hrsACE2 human ACE2 human body Impact increase in measure mechanism morbidity and mortality organ organs outbreak outcome peptide peptides physiological progression putative receptor Regulation respiratory rises SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severity severity of COVID-19 Spread Stage susceptibility the disease Transmissibility variants various tissue various tissues widespread [DOI] 10.3389/fcimb.2021.753721 PMC 바로가기 [Article Type] Review
Thrombosis post COVID-19 vaccinations: Potential link to ACE pathwaysCorrespondence Published on 2021-10-012022-10-05 Journal: Thrombosis research [Category] SARS, 변종, [키워드] ACE COVID-19 pathway Potential [DOI] 10.1016/j.thromres.2021.08.018 [Article Type] Correspondence