Expression of Human ACE2 N-terminal Domain, Part of the Receptor for SARS-CoV-2, in Fusion With Maltose-Binding Protein, E. coli Ribonuclease I and Human RNase AMicrobiology Published on 2021-06-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] E. coli ribonuclease I (RNase I) ACE2 ACE2 protein Antiviral antiviral agent bacterial cell Cartoon cleaving degrade dsRNA E. coli enzyme evaluated expressed expression fusion fusion protein Genome Human human ACE2 receptor human RNase A-ACE2NTD fusion in vitro Inclusion Infection Membrane proteins N-terminal N-terminal domain Nucleocapsid proteins Part Protein Proteins provide purified receptor ribonuclease RNA RNA degradation RNase RNase I-ACE2NTD fusion RNase III RNases SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 virus single-stranded soluble fraction Strains viral genome viral nucleic acids virions [DOI] 10.3389/fmicb.2021.660149 PMC 바로가기 [Article Type] Microbiology
SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal TractCell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 ACE2 protein acute respiratory syndrome analyzed antibody Atla Cancer cancer cell cancers CCK-8 cells Colon Colon cancer coronavirus correlation counting death digestive distribution enzyme expressed expression expression level expression pattern Gastrointestinal gastrointestinal cancers gastrointestinal tract heterogeneous host cell Human IHC immunohistochemistry in vitro independent infect infected with SARS-CoV-2 Interaction liver Liver cancer not affect not correlated pancreas pancreatic Pancreatic cancer paraffin-embedded Patient Prognosis prognosis of patient Prognostic marker proliferation proportion protein expression receptor Result SARS-CoV-2 significantly significantly increased staining survival Symptoms tissue tissues tract tumor cell line was tested [DOI] 10.3389/fcell.2021.659809 PMC 바로가기 [Article Type] Cell and Developmental Biology
Plasma ACE2 predicts outcome of COVID-19 in hospitalized patientsResearch Article Published on 2021-06-042022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 protein acute respiratory syndrome Admission Analysis association bind Cell Clinical data Cohort collected Comprehensive condition coronavirus coronavirus disease COVID-19 COVID-19 illness COVID-19 negative COVID-19 patient COVID-19 positive patient Department disease Emergency enzyme hospitalized patient hypertension Illness severity include Infection Kidney disease outcome outcomes Patient plasma platform predict risk factor SARS-CoV-2 severity significantly higher used data virus [DOI] 10.1371/journal.pone.0252799 PMC 바로가기 [Article Type] Research Article
Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progressionMaackia amurensis seed lectin(MASL)이 SARS-CoV-2 감염 및 COVID-19 질병 진행을 억제할 가능성이 있는 구강 편평 세포에 다면발현 작용을 한다는 증거Article Published on 2021-06-012022-09-11 Journal: Experimental cell research [Category] SARS, 치료제, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 proteins ACE2 receptor addition agent Antiviral antiviral agent ARDS bind binding can be used caused Cell confirmed COVID-19 case COVID-19 COVID-19 disease COVID-19 patients Culture death decrease epithelial cell epithelial cells Express expression glycosylated glycosylation host cells identify infect infect cell Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inhibit inhibit SARS-CoV-2 international public health kidney lectin Maackia amurensis Modification oral oral mucosa Oral squamous cells pandemic pleiotropic progression Protein respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sialic acid Spike protein squamous suppresse target the SARS-CoV-2 the SARS-CoV-2 virus viral-host interaction [DOI] 10.1016/j.yexcr.2021.112594 PMC 바로가기 [Article Type] Article
Update and Supplementary Articles Proteins of SARS CoV-2, Which Causes COVID-19, and the Interacting Proteins업데이트 및 보충 기사 COVID-19를 유발하는 SARS CoV-2의 단백질 및 상호 작용하는 단백질Review Published on 2021-06-012022-09-11 Journal: The protein journal [Category] SARS, 변종, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 article cause caused coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Enzymes infective journal mutant mutants pandemic Protein Proteins SARS CoV SARS CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus spike Spike protein strain Topic variant virus [DOI] 10.1007/s10930-021-10000-1 PMC 바로가기 [Article Type] Review
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection초강력 4량체화된 ACE2 단백질은 SARS-CoV-2 바이러스 감염의 강화된 중화를 나타냅니다Article Published on 2021-05-192022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE-2 ACE2 ACE2 protein ACE2 receptor acute respiratory syndrome addition affected angiotensin angiotensin converting enzyme Anti-viral antibodies approaches binding block blocks complex coronavirus COVID-19 dimeric domain Drug discovery Efficacy enzyme Fc region forms human cells human immunoglobulin Immunoglobulin immunology Infection Interaction molecular weight monoclonal antibodies monomeric Mutation neutralization p53 Protein protein complex pseudovirus Quad receptor Receptor binding respiratory SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 pseudovirus SARS-CoV-2 virus SARS-CoV-2 virus infection Severe acute respiratory syndrome Spike protein the SARS-CoV-2 the spike protein therapeutic therapy unlikely variant Viral Viral antigen viral antigens virus infection [DOI] 10.1038/s41598-021-89957-z PMC 바로가기 [Article Type] Article
Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudovirusesLetter Published on 2021-05-102022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, Fulltext, SARS, [키워드] ACE2 protein alleviate Biochemistry Cell Biology conditioned downregulate Infection lenalidomide pseudovirus SARS-CoV-2 spike protein [DOI] 10.1038/s41392-021-00608-1 PMC 바로가기 [Article Type] Letter
Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyteOriginal Investigation Published on 2021-05-072022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 receptor affecting alterations Autopsies Autopsy binding cardiomyocyte cellular entry coronavirus disease COVID-19 COVID-19 infection Deceased diabete diabetes diagnosed domain Effect evaluate evaluate the effect evaluated expression Glucose glycosylated glycosylated forms hACE2 heart Hospitalized human ACE2 in vitro include Infection Invasion investigated Italy lysine mechanism Modification monomeric myocardial damage objective oligomerization Patient patients patients with diabete protease Protein rationale residue SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV2 Serine spike supplementary material susceptibility tissue TMPRSS2 TMPRSS2 protein Total transmembrane upregulation viral invasion was performed [DOI] 10.1186/s12933-021-01286-7 PMC 바로가기 [Article Type] Original Investigation
The role and significance of angiotensin‐converting enzyme 2 peptides in the treatment of coronavirus disease 2019코로나바이러스 질환 치료에서 안지오텐신 전환 효소 2 펩티드의 역할과 중요성 2019Review Published on 2021-05-052022-09-10 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 protein acute respiratory distress syndrome Amino acid amino acids angiotensin angiotensin‐converting enzyme 2 binding binding ability caused coronavirus disease Coronavirus disease 2019 COVID‐19 drug Drug development drug prediction enzyme Health Infection information involved lead life lysine Mutation Novel coronavirus optimization peptide peptides Prevent Region Regulation Stress treat Treatment [DOI] 10.1002/jcla.23789 PMC 바로가기 [Article Type] Review
Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells플루티카손 프로피오네이트는 1차 인간 비강 상피 세포에서 폴리(I:C) 유도 ACE2를 억제합니다Cellular and Infection Microbiology Published on 2021-04-262022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료기술, [키워드] ACE2 ACE2 expression ACE2 protein Activation Affect affected agonist analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell entry collected Corticosteroid COVID-19 dissemination enzyme epithelial cells evaluate examined expression expression of gene fluticasone fluticasone propionate Fold change followed by Gene Expression Health health problem HNECs host cells Human immunoblot immunofluorescence incubated Incubation individuals Infection initial innate immune interferon intranasal intranasal steroid spray investigated mRNA expression nasal Nasal cavity nasal epithelial cell nasal mucosa NFκB objective poly(I:C poly(I:C) promote propionate protease Protein quantitative PCR receptor regulated required reservoir Result SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral SARS-CoV2 Serine serine 2 significantly increased Spread steroid suppresse suppressed thought TLR TLR agonists TLR3 TMPRSS2 Toll-like receptors transmembrane transmembrane protease serine 2 Viral virus infection [DOI] 10.3389/fcimb.2021.655666 PMC 바로가기 [Article Type] Cellular and Infection Microbiology