Editorial: Macrophage heterogeneity and responses to influenza virus infectionArticle Published on 2012-07-012023-06-09 Journal: Journal of leukocyte biology [Category] 신종인플루엔자, [키워드] alveolar macrophage cytokine H5N1 lung monocyte Pathogenesis [DOI] 10.1189/jlb.0312130 PMC 바로가기
Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected MiceResearch Article Published on 2009-10-232022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell [DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article
Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARSResearch Published on 2005-05-112022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] abnormality acute phase acute respiratory syndrome alveolar cell alveolar macrophage Alveolar macrophages BALF Bronchoalveolar lavage Bronchoalveolar lavage fluid CD4/CD8 CD8 cell count cells clearance compared Computed tomography controls coronavirus correlated Course cytokine Cytokines described desquamation detected determine dysregulation Factor Fever High-resolution High-resolution CT HRCT hyaline membrane formation IL-6 IL-8 independent infiltration Inflammatory investigated lung Lung inflammation MCP-1 Microscopy mononuclear cell non-randomized occur Particle Patient patients persistence persistent Plasma cytokine profiles RANTES Resolution Result Retrospective analysis SARS SARS patient significantly subpopulations T lymphocyte T-cell therapy TNF-α [DOI] 10.1186/1465-9921-6-42 PMC 바로가기 [Article Type] Research