Social Distance during the COVID-19 Pandemic Reflects Perceived Rather Than Actual RiskArticle Published on 2021-05-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] actual actual risk adopted affected analogue Anxiety Contagion COVID-19 COVID-19 outbreak COVID-19 pandemic distance effective event expressed Face mask First wave individual individuals Infection interpersonal space Italian region Italy measure participated Perceived Perceived risk questionnaire Regulation risk Risk perception scale social distancing Visual [DOI] 10.3390/ijerph18115504 PMC 바로가기 [Article Type] Article
Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug CandidateArticle Published on 2021-05-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acid Action activity acute respiratory syndrome analogue anti-SARS-CoV-2 antiviral activity candidate Candidates carried chlorinated Compound concentrations coronavirus coronavirus disease COVID-19 derivative drug escaped examined global pandemic impair in vitro in vivo inhibitory concentration maslinic acid MERS-CoV mode molecular docking non-toxic Novel coronavirus oleanolic acid SAR SARS-CoV-2 SARS-CoV-2 main protease screened Strong synthetic tested Treatment viral replication [DOI] 10.3390/pathogens10050623 PMC 바로가기 [Article Type] Article
Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 ScaffoldPharmacology Published on 2021-05-132022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activities analogue anti-SARS-CoV-2 antiviral activity antiviral drug antiviral drugs approved caused Compound COVID-19 cysteine protease Cytokines storm drug Efficacy FDA food immunomodulators immunomodulatory activity inhibit M pro MPro marine sponge metabolites Modification natural nucleoside Nucleoside analogues pandemic pharmacophore Remdesivir reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 serine protease Source Sponge TMPRSS2 unique United State [DOI] 10.3389/fphar.2021.666664 PMC 바로가기 [Article Type] Pharmacology
Effect of guided imagery on anxiety, muscle pain, and vital signs in patients with COVID-19: A randomized controlled trialRandomized Controlled Trial Published on 2021-05-012022-10-05 Journal: Complementary therapies in clinical practice [Category] SARS, 임상, [키워드] analogue Anxiety assigned clinical clinical trial collected complementary COVID-19 determine Effect groups Guided imagery high mortality rate indicated intensity Intervention intervention group inventory oxygen saturation Pain Patient patients with COVID-19 Randomized controlled trial Randomly recruited scale significant difference Systolic blood pressure the mean two group Visual vital sign with COVID-19 [DOI] 10.1016/j.ctcp.2021.101335 PMC 바로가기 [Article Type] Randomized Controlled Trial
Molecular designing, crystal structure determination and in silico screening of copper(II) complexes bearing 8-hydroxyquinoline derivatives as anti-COVID-19항COVID-19로서 8-하이드록시퀴놀린 유도체를 함유하는 구리(II) 착물의 분자 설계, 결정 구조 결정 및 인실리코 스크리닝Article Published on 2021-05-012022-08-31 Journal: Bioorganic chemistry [Category] MERS, SARS, 신약개발, 치료제, [키워드] active site ADP-ribose-1 monophosphatase enzyme analogue binding characterized Chloroquine complexes copper Copper complex COVID-19 defined derivative drugs earth enzyme everything favor group hydrophobic Hydroxychloroquine in silico indicated life Ligand ligands market mechanism of action mental health moment pandemic physical physical and mental health polar ribose SARS-CoV-2 screened target protein tested Vaccine Viral virus X-ray diffraction [DOI] 10.1016/j.bioorg.2021.104772 PMC 바로가기 [Article Type] Article
Broad-Spectrum Antiviral Strategies and Nucleoside AnaloguesReview Published on 2021-04-132022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] absence analogue antiviral drugs antiviral molecule antiviral nucleoside analogue antiviral strategy broad-spectrum antiviral broad-spectrum antivirals Chain terminator drug drugs targeting Ebola Efficacy Epidemic Health include Influenza lethal mutagenesis limitations mechanism MERS-CoV Middle East new strain nucleoside nucleoside analogue Nucleoside analogues outbreak pandemic public health emergency Replication respiratory SARS-CoV-2 Strategy threat Vaccine development virus virus infection viruses Zika [DOI] 10.3390/v13040667 PMC 바로가기 [Article Type] Review
In silico structure-based discovery of a SARS-CoV-2 main protease inhibitorResearch Paper Published on 2021-04-102022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, [키워드] acute respiratory syndrome analogue Antiviral antiviral target caused cleavage Compound Concentration coronavirus COVID-19 develop Drug discovery effective enzyme facilitate half-live identify in silico inhibitor inhibitors inhibitors of SARS-CoV-2 M pro morbidity Mortality novel lineage pandemic performed platform protease Replication SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 replication serum structure-based screening trichostatin A [DOI] 10.7150/ijbs.59191 PMC 바로가기 [Article Type] Research Paper
The course of subjective and objective chemosensory dysfunction in hospitalized patients with COVID-19: a 6-month follow-upRhinology Published on 2021-04-102022-10-31 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, MERS, SARS, [키워드] analogue Anosmia chemosensory Chemosensory dysfunction Cohort control groups coronavirus Course COVID-19 diagnosed dysfunction Effect elevated examined FIVE Follow-up hospitalized patient Hyposmia identification impairment Infection infection with SARS-CoV-2 initial negative control no difference olfactory dysfunction Patient patients performed positive patients Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2-positive patient scale significantly Smell smell training strip suffered Taste Test Visual [DOI] 10.1007/s00405-021-06796-4 PMC 바로가기 [Article Type] Rhinology
Potential of CRISPR/Cas13 System in Treatment and Diagnosis of COVID-19Review Article Published on 2021-03-252022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] ACE2 acute respiratory distress analogue antiparasitic drug antiviral medicine approved ARDS blood vessel organoids cause convalescent COVID-19 CRISPR/Cas13 Diagnosis diagnostic disease drug FDA food global pandemic hrsACE2 human Angiotensin-converting enzyme human kidney Infection inhibit inhibitor Ivermectin novel coronavirus disease organoids overcome Potential Pyrexia recent finding Remdesivir Research sarbecovirus Started syndrome System therapy Treatment Trial Vaccine Vaccines virus WHO widespread World Health Organization Wuhan, China [DOI] 10.1055/s-0041-1723086 PMC 바로가기 [Article Type] Review Article
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum인간 혈청에서 2차원 동위원소 희석 LC-MS/MS 방법을 통한 7가지 용도 변경 COVID-19 약물 렘데시비르(대사산물 GS-441524 포함), 클로로퀸, 히드록시클로로퀸, 로피나비르, 리토나비르, 파비피라비르 및 아지트로마이신의 동시 정량화Article Published on 2021-03-202022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 신약개발, 치료제, [키워드] analogue analytical column antiviral therapy Azithromycin Bioanalytical Method Validation Chloroquine Concentration controls COVID-19 COVID-19 pandemic COVID-19 patient develop Dilution drug drug candidate drugs Efficacy and safety European Medicines Agency Favipiravir GS-441524 human serum Hydroxychloroquine inaccuracy injection Isotope Isotope dilution liquid chromatography tandem mass spectrometry (ID-LC–MS/MS) Liquid chromatography Lopinavir LOPINAVIR AND RITONAVIR mass spectrometry metabolite protein precipitation protocol provided quantification quantitative assay Remdesivir Ritonavir robust sensitivity separated serum Seven Simultaneous solid phase Tandem mass spectrometry therapeutic drug Therapeutic Drug Monitoring Treatment two-dimensional Volume were used [DOI] 10.1016/j.jpba.2021.113935 PMC 바로가기 [Article Type] Article