Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms초강력 인간 항체는 여러 메커니즘을 통해 SARS-CoV-2 공격으로부터 보호합니다.Research Article Published on 2020-11-202022-09-14 Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 진단, 치료법, [키워드] ACE2 ACE2 receptor activate acute respiratory syndrome angiotensin-converting enzyme 2 antibodies antibody antibody cocktail bind binding block caused characterized circulating coronavirus efficient electron microscopy epitope fatality functions hamster host receptor include Infection initiated Isolation Microscopy multiple mechanism mutants neutralize neutralizing antibody Prevent Prophylaxis PROTECT protective immune response receptor-binding domains S309 SARS-CoV-2 SARS-CoV-2 isolate Science Spread Structure therapeutic option therapy Trimeric spike protein viral escape viral infection virus [DOI] 10.1126/science.abe3354 PMC 바로가기 [Article Type] Research Article
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing StrategyArticle Published on 2020-11-122023-06-19 Journal: Cell [Category] Fulltext, SARS, [키워드] antibody cocktail COVID-19 cryo-EM epitope hamster Mutation neutralizing antibody RBD SARS-CoV-2 spike [DOI] 10.1016/j.cell.2020.09.035 PMC 바로가기
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktailReport Published on 2020-08-212022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibodies antibody antibody cocktail antibody resistance antibody treatment approach binding characterized convalescent convalescent patient coronavirus criteria decrease Diseases effective effort escape mutant expresse generate host cells Human humanized mice neutralization Neutralizing antibodies panel of antibody Prevent pseudovirus Receptor binding domain recovered patients SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 spike protein Science selected selective Spike mutant Spike protein spike variants survivor the RBD the spike protein therapeutic three-dimensional structure Treatment viral spike virus virus mutation [DOI] 10.1126/science.abd0827 PMC 바로가기 [Article Type] Report
Focus shifts to antibody cocktails for COVID-19 cytokine storm News Published on 2020-08-052022-10-05 Journal: Nature biotechnology [Category] 임상, [키워드] antibody cocktail COVID-19 cytokine storm focus [DOI] 10.1038/s41587-020-0634-9 [Article Type] News
In vivo expressed biologics for infectious disease prophylaxis: rapid delivery of DNA-based antiviral antibodiesReview Published on 2020-07-052023-06-15 Journal: Emerging Microbes & Infections [Category] MERS, [키워드] antibody cocktail antivirals DNA therapeutics Electroporation Emerging infectious disease gene transfer Neutralizing antibodies [DOI] 10.1080/22221751.2020.1787108 PMC 바로가기 [Article Type] Review
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodiesReport Published on 2020-06-152022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] antibodies antibodies binding antibody antibody cocktail antibody resistance approach Combination COVID19 effective escape mutant in vitro Mutation neutralize occurred overlapping Prevent Region resulting SARS-CoV-2 SARS-CoV-2 spike protein Spike mutant spike variant the spike protein Treatment [DOI] 10.1126/science.abd0831 PMC 바로가기 [Article Type] Report