Quantitative SARS-CoV-2 Spike Antibody Response in COVID-19 Patients Using Three Fully Automated Immunoassays and a Surrogate Virus Neutralization TestArticle Published on 2021-08-192022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Abbott antibody antibody level Area AUC AUC value binding antibody unit binding antibody units chemiluminescent immunoassay CLIA collected correlated COVID-19 COVID-19 infection COVID-19 patients Curve Genscript highest immune response Immune status immunoassay Infection neutralizing antibody Patient Protein quantitation regression analysis response Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 S protein severe disease Siemen Siemens spike Standardization surrogate sVNT symptom onset Test vaccination virus neutralization test [DOI] 10.3390/diagnostics11081496 PMC 바로가기 [Article Type] Article
Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults핀란드 어린이 및 성인에서 풍토성 코로나바이러스 OC43 및 229E 항체의 혈청유병률 및 SARS-CoV-2 교차 반응성Article Published on 2021-08-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS, 진단, 치료기술, [키워드] 229E Adults affected affecting age antibody antibody cross-reactivity antibody level antibody levels causative agents children contribute coronavirus correlated correlation cross-reactive cross-reactivity Endemic endemic HCoVs endemic human coronaviruses Finnish HCoV HCoVs human coronavirus magnitude no difference OC43 respiratory Respiratory tract infections SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 pandemic sera serology Seroprevalence significantly significantly higher specific antibodies [DOI] 10.1016/j.clim.2021.108782 PMC 바로가기 [Article Type] Article
Antibody Responses After mRNA-Based COVID-19 Vaccination in Residential Older Adults: Implications for Reopening거주 노인에서 mRNA 기반 COVID-19 백신 접종 후 항체 반응: 재개방에 대한 시사점Article Published on 2021-08-012022-09-11 Journal: Journal of the American Medical Directors Associat [Category] SARS, 치료기술, [키워드] adaptive Adults advanced age All participant All participants Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody level antibody levels Antibody Response assisted living B.1.1.7 Beckman Coulter blinded calculated Care coefficients collected Community condition conducted correlated correlation COVID-19 COVID-19 vaccines criteria cross-sectional Descriptive statistics detectable evaluated Factor greater IgG immune response immune responses Immunity Immunoglobulin Impact impair independent independent living Long-term care magnitude males mounted mRNA mRNA-based mRNA-based COVID-19 vaccine Multiple linear regression multiple linear regression analysis neutralization titer neutralization titers nursing homes Older older adult participant Pearson correlation personal care personal care living Pittsburgh protective effect Protective effects provide pseudovirus pseudovirus neutralization titers. Quality improvement reflex reopening response risk SARS-CoV-2 SARS-CoV-2 pseudovirus sera setting Spearman Steroids use of steroids vaccination Variation [DOI] 10.1016/j.jamda.2021.06.006 PMC 바로가기 [Article Type] Article
Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers의료 종사자의 AZD1222/Covishield 백신 단일 용량에 대한 면역 반응Article Published on 2021-07-292022-09-10 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] ACE2 Adaptive immunity age and gender antibody antibody level antibody levels Antibody titer Antibody titers approval AZD1222 B.1.1.7 B.1.351 B.1.351 variant blocking antibodies carried Cohort COVID-19 vaccine dose ELISpot assay ELISpot assays Ex vivo HCW HCWs Health care Health care worker health care workers Health occupations healthcare worker Healthcare workers IFNγ immunogenicity large cohort naïve Neutralization assay PROTECT RBD Receptor binding domain response SARS-CoV-2 Seroconversion seroconvert seroconverted significantly higher single dose sub-cohort sVNT T cell T cell response the RBD titre titres Vaccine vaccine dose vaccinees Vaccines variant variants wild-type SARS-CoV-2 wild-type virus [DOI] 10.1038/s41467-021-24579-7 PMC 바로가기 [Article Type] Article
Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals혈청 양성 및 혈청 형성 개인에서 SARS-CoV-2 mRNA 백신 투여 동안 체액 면역 반응Research Article Published on 2021-07-262022-09-01 Journal: BMC Medicine [Category] SARS, 진단, [키워드] administration antibody antibody level antibody levels Antibody Response Antibody responses Antibody titers approved binding Binding assays BNT162b2 caused comparable coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated dose doses Efficacy epitope Epitopes first vaccination global pandemic guide had no high resolution humoral immune responses IgA IgG IgM antibody immune immune response immune responses immunization immunodominant individual Infection mapped Messenger RNA mRNA mRNA vaccine peptide peptides Pfizer-BioNTech protein antigen regimens Result S1 and S2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 viral SARS-CoV-2 virus seronegative seropositive seropositive individual seropositive individuals significantly higher single dose specificity Spike protein subunit supplementary material Support the antibody response the SARS-CoV-2 the SARS-CoV-2 virus USA vaccination Vaccine Viral viral infection while [DOI] 10.1186/s12916-021-02055-9 PMC 바로가기 [Article Type] Research Article
Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France프랑스 북동부 어린이와 성인의 SARS-CoV-2 및 계절성 코로나바이러스에 대한 체액 면역Research Paper Published on 2021-07-232022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 임상, 진단, [키워드] 229E Action adolescents and adults age all age group all age groups antibody antibody level antibody levels Antibody Response Antibody responses Betacoronavirus Biology children collected COVID-19 COVID-19 pandemic cross-protective immunity cross-reactivity cross-sectional disease Emerging infectious diseases European Evidence finding France French funding HCoV highest HKU1 Horizon Hospital admission human coronavirus Immunity immunoassays individuals infected individuals Infection infection with SARS-CoV-2 infections Infectious disease Infectious diseases large cohort levels of antibody lowest luciferase Multiplex assay neutralisation assay NL63 Non-COVID-19 observé OC43 pseudotype Research SARS-CoV-2 SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody seasonal coronavirus seasonal coronaviruses Sero-epidemiology seronegative seropositive individual seropositive individuals Seroprevalence serum sample serum samples severity specific antibodies specific antibody spike supported union unit were assessed [DOI] 10.1016/j.ebiom.2021.103495 PMC 바로가기 [Article Type] Research Paper
Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom영국 총 인구에서 45,965 명의 SARS-COV-2 백신에 대한 항체 반응Clinical Trial Published on 2021-07-212022-08-13 Journal: Nature Microbiology [Category] Fulltext, SARS, 임상, 진단, [키워드] Adults antibody level antibody levels Antibody Response Antibody responses BNT162b2 ChAdOx1 Cohort COVID-19 vaccine Diagnostic markers General population had no indication indications individual individuals infection with SARS-CoV-2 latent class long-term health conditions longitudinal male of BNT162b2 Older Quantitative quantitative antibody level quantitative antibody levels receiving response SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose seroconversion rate seroconversion rates single dose subgroups United Kingdom Vaccine vaccine dose viral infection waned [DOI] 10.1038/s41564-021-00947-3 PMC 바로가기 [Article Type] Clinical Trial
Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19Covid-19 후 최대 12.5 개월까지 의료 종사자의 혈청 양성 및 재감염의 지속성 및 기준 결정 요인Correspondence Published on 2021-06-282022-09-01 Journal: BMC Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] allergies Anosmia anosmia/hypogeusia antibodies antibody antibody level antibody levels Antibody Response Antibody responses Antigen baseline Baseline determinants Care Cohort correlated COVID-19 COVID-19 symptom COVID-19 symptoms COVID-19 vaccine determinant domain Duration Fever first episode Health Health care Health care worker health care workers Hope Hospitalization Hypogeusia IgA IgG IgG response IgG responses IgM Immunity individual Kinetics long-lasting Occurrence Patient Primary Health Care prospective cohort raise Reinfection SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike antigen seronegative Seropositivity significantly smoking Spanish Spike antigen STABLE subset supplementary material symptoms onset [DOI] 10.1186/s12916-021-02032-2 PMC 바로가기 [Article Type] Correspondence
Longitudinal assessment of anti-SARS-CoV-2 antibody dynamics and clinical features following convalescence from a COVID-19 infectionCOVID-19 감염에서 회복된 후 항-SARS-CoV-2 항체 역학 및 임상 특징의 종단적 평가Article Published on 2021-06-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Anti-spike antibody Antibody dynamics antibody kinetics antibody level antibody levels Antibody titers association Asymptomatic body mass body mass index Chain Reaction clinical feature Clinical features collected concerning convalescence coronavirus correlated COVID-19 infection detectable disease severity dysfunction Fever follow-up period Frequency Gustatory immune response Immunity Immunoglobulin long-lasting Longevity longitudinal longitudinal analysis Longitudinal assessment material olfactory participant Participants patients polymerase chain polymerase chain reaction post-COVID syndrome qRT-PCR Quantitative questionnaire Receptor binding domain reported symptoms respiratory SARS-CoV-2 SARS-COV-2 infection Serological immune response. serological response serum sample serum samples severe acute respiratory syndrome Coronavirus severity smoking smoking status subunit suffered Symptom syndrome the disease were assessed [DOI] 10.1016/j.ijid.2021.04.080 PMC 바로가기 [Article Type] Article
Evaluation of Dried Blood Spot Testing for SARS-CoV-2 Serology Using a Quantitative Commercial Assay정량적 상업 분석을 사용한 SARS-CoV-2 혈청학에 대한 건조 혈반 검사 평가Article Published on 2021-05-222022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] anti-S antibody antibody level antibody levels Antibody Response Antibody responses Blood Characteristics Concordance correlated COVID-19 DBS sample DBS samples Diagnosis dried blood spot Dried blood spots elution extrapolation facilitate False negative false negatives feasible Immunity Infection investigated Laboratory testing occur PCR-confirmed COVID-19 patient PCR-confirmed COVID-19 patients phlebotomy plasma plasma antibody Quantitative reduced Roche SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody serologic testing serology spike glycoprotein spot tested Testing vaccination virus viruses widespread [DOI] 10.3390/v13060962 PMC 바로가기 [Article Type] Article